Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Vascular remodeling"”.
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
Cardiovascular disease, including hypertension and coronary artery disease (CAD), accounts for one in every three deaths in the United States with a direct cost estimated at $286 billion each year. Angiotensin II (Ang II), one of the biologically active peptides of the renin-angiotensin system, …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… promote gene transcription of ligands such as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is sustained. Results suggest that …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… are available for this disease. The current endovascular medications (e.g., angioplasty or stents) only relieve the clinical symptoms while the surgical therapies (e.g., bypass or endarterectomy) require grafting vessels from a healthy organ to the diseased limb of the patient. However, even with …
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Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling
… study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control …
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The role of fibroblast growth factor-2 (FGF2) in vascular remodeling and adaptation
… (FGF2) is required during diseased-related vascular growth and remodeling in the adult organism. Given previous research, it is generally assumed that FGF2 is an important regulator of vessel growth during various pathophysiological processes (e.g. tissue ischemia, vessel injury, and …
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
Arterial remodeling is a major pathophysiological mechanism underlying clinical cardiovascular disorders such as hypertension, atherosclerosis and restenosis. We examined heparan sulfate proteoglycan homeostasis as a mechanism of regulation of arterial vascular remodeling in response to altered …
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Role of vascular remodeling in the accumulation, clearance, and biodistribution of biomolecular factors in melanoma
… to fill. The central hypothesis is that tumor vascular remodeling redirects the organism-wide exposure of SF secreted locally within the tumor microenvironment, which may negatively contribute to disease burden by altering the bioavailability of molecules important to systemic disease …
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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
… not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it …
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VEGF and Sympathetic Perivascular Nerves Contribute to Hypoxic Remodeling of Ovine Cranial Arteries
… pathologies that include compromised fetal cardiovascular structure and function. Mechanisms involved remain unclear. Because hypoxia increases production of VEGF, known to modulate smooth muscle (SM) phenotype, this thesis explored the hypothesis that VEGF contributes to hypoxic fetal vascular …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic brain injury, myocardial ischemia, diabetes, and developmental anomalies. With this remodeling comes changes in vessel …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… is a key regulator of local blood distribution, vascular resistance and overall blood pressure (BP). Arterioles and capillaries are two important components of the microcirculation, which can undergo remodeling such as arteriogenesis, angiogenesis, or capillary rarefaction. Vascular remodeling …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… since inflammation has been associated with vascular remodeling and PAH in both patients and animal models, however, whether allergic inflammation could contribute to PAH in patients with BMPR2 mutations is unknown. Hence, the first project examined the role of allergic inflammation as a …
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ROLE OF CKD AND CASPASE-1 IN NEOINTIMAL HYPERPLASIA DEVELOPMENT
Vascular access dysfunction is a cause of morbidity and mortality in chronic kidney disease (CKD) patients that require hemodialysis. The major cause of vascular access failure is venous stenosis due to neointimal hyperplasia (NH). Vascular smooth muscle cells (VSMC) are critical for the …
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The role of Ras-related C3 botulinum toxin substrate 1 (RAC1)-dependent pathway in the regulation of uterine function during early pregnancy
… consequences, including compromised uterine vascular remodeling and angiogenesis, maternal blood vessel hemorrhage and placental abnormalities resulting in embryo loss around days 10 to 12 of pregnancy. Fetuses that survived to day 15 of pregnancy showed indications of intrauterine growth …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… treatment in MCT-PAH over 12 days regressed vascular remodeling, improved hemodynamics, and reduced RV hypertrophy as shown by quantitative staining of lung tissue and RVs, echocardiography, and right heart catheterization. Conclusion: Drpitor1a is an efficacious treatment for PAH in female …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… hyperplasia are major causes of small diameter vascular conduit (SDVC) failure. The present study was aimed to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with …
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TISSUE ARCHITECTURE AND INTERCELLULAR COMMUNICATION: MEDIATORS OF PROTECTIVE OR PATHOGENIC INTERFERON RESPONSES
… exposure of extravillous trophoblast limited vascular remodeling, which is crucial for successful implantation. By exemplifying both protective effects (forebrain organoid and mouse models) and pathogenic consequences (implantation-on-a-chip) of robust IFN responses, future studies should …
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Targeting Metabolic Alterations Associated With Smooth Muscle Α-Actin Pathogenic Variant Attenuates Moyamoya-Like Cerebrovascular Disease
… disease and moyamoya disease-like (MMD) cerebrovascular disease. The MMD-like cerebrovascular disease in SMDS patients is marked by bilateral steno-occlusive lesions in the distal internal carotid arteries (ICAs) and their branches. To study the molecular mechanisms that underlie the …
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Sex Differences in Collateral Remodeling Following Hindlimb Arterial Occlusion
… the possible differences in underlying vascular compensation mechanisms is crucial. With arterial occlusions, necrosis and tissue injury can be naturally mitigated by the collateral circulation, improving patient prognosis. Previous sex-comparison studies describing differences in …
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