Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Vascular networks"”.
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Procedural generation of vascular networks for tissue engineering
… challenge in tissue engineering is that of vascularization: tissue constructs at length scales above the diffusive length without embedded perfusable channels will be unable to supply oxygen and nutrients to—or remove waste from—cells within the construct, leading to necrosis. This has …
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Semi-Automated Reconstruction of Vascular Networks in Knife-Edge Scanning Microscope Mouse Brain Data
… be used in the reconstruction of neuronal and vascular structures in the mouse brain. Tracing the vascular network of the brain and reconstructing the topology allows us to map the circulatory pathways inside the brain. Studying these cerebro-vascular networks is important to understand and …
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Numerical methods for computationally efficient and accurate blood flow simulations in complex vascular networks: Application to cerebral blood flow
… task, due to the high complexity of cerebral vascular networks and the difficulties that consequently arise to describe and reproduce the blood flow dynamics in these vascular districts. The first part of this work is devoted to the development of efficient numerical strategies for blood flow …
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Biomimetic vascular self-healing systems for cementitious materials
… of inspiration in engineering applications and vascular networks, as in human skin and in a tree leaf, are one attribute that has received attention in the design of resilient structures. A vascular system houses healing agent within its interconnected networks which are incorporated within a …
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High Resolution Maps of the Vasculature of An Entire Organ
<p>The structure of vascular networks represents a great, unsolved problem in anatomy. Network geometry and topology differ dramatically from left to right and person to person as evidenced by the superficial venation of the hands and the vasculature of the retinae. Mathematically, we may state …
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
… organ failure. However, producing hierarchical vascular networks that sustain the viability and function of cells within human-scale organs after implantation remains a major challenge. Sacrificial templating has emerged as a promising strategy that could overcome this challenge by confining …
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INDUCIBLE CELL EXPRESSION OF MMP1A FOR TUNABLE DEGRADATION OF BIOMIMETIC SCAFFOLDS
Therapeutic vascularization remains a challenge in the field of tissue engineering. Designing tissues for long-term success involves finding methods to incorporate functional vascular networks capable of providing nutrients and oxygen and removing wastes from surrounding cells. Recent advances have …
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Assessment of Morphology and Hemodynamics in Normal and Remodeled Microvasculature with Parameter Sensitivity Analysis
… characteristics of normal and remodeled vascular networks in the mouse gracilis muscle. To this end, previously developed models to assess flows and vascular branching were used to assess the normal and remodeled microcirculatory networks. The analysis revealed that the average individual …
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Self-healing of impact damage in vascular fiber-reinforced composites
Vascular fiber-reinforced composites mimic biological systems to allow pluripotent multifunctional behavior in synthetic engineering materials. In this dissertation, methods are explored for recovering mechanical performance of a composite material after an out-of-plane impact event using vascular …
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Algorithmic generation of vascular network models for additive manufacturing
Fabrication of functional vascularised three-dimensional tissue constructs has been a long-standing objective in the field of tissue engineering. Currently, the main limitation in this field is the inability to produce fully vascularised tissue with an internal mass transport system (vascular …
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The Impact of Increased Collateral Flow on Transverse Arteriolar Microvascular Tree Morphology
… tree structure. The previous process involved a vascular casting technique that utilized black India ink as the casting agent and manual measurement of vessel morphology with ImageJ. This study decreased the complexity of the casted samples by using a casting compound called Microfil. Microfil’s …
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Investigating the defects of postnatal global Fli1 deletion in a mouse model
… developed a phenotype displayed disorganized vascular networks, fibrosis and proinflammatory cytokines and chemokines in the skin and lungs after 4 and 8 weeks of Fli1 deficiency. Increased macrophage and dendritic cell populations were observed in the lungs after 8 weeks. Fli1flox/flox CAG …
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Thermal regulation of vascularized fiber-reinforced polymer matrix composites
… outside of their service temperature. Internal vascular networks provide a platform for thermal regulation, allowing for on-demand, adaptive heat removal and preservation of material properties. This dissertation uses the established Vaporization of Sacrificial Components (VaSC) technique for …
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Sacrificial polymers for rapid manufacturing of bioinspired vascular materials
Synthetic vascular systems, inspired by hierarchical vascular networks for mediating heat and mass transport in biological structures, have gained tremendous interest in the fields of microfluidics, soft robotics, microelectronics, battery packaging, and civil infrastructure. Strategies for …
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Embedded microvascular networks for electronically reconfigurable materials
Microvascular networks in biological systems carry out various functions, such as damage repair, temperature regulation, and nutrient transport. Biological vasculature has inspired the use of microfluidic networks in various synthetic materials to achieve similar functionality such as …
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Extracellular Matrix Contributions to Early Vascular Development and Pericyte Precursor Dynamics
… from the body. The formation of a functioning vascular system depends on the close coordination of many cell types and, on the capillary level, specifically endothelial cells and pericytes as well as the surrounding protein microenvironment, known as the extracellular matrix (ECM). Impaired …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
Stable vascular networks are prerequisite for scaffold-guided reconstruction of large voluminous bony defects. However, induction of angiogenesis remains a major challenge for bone-tissue engineering. The present in vivo study evaluates human umbilical cord derived vascular endothelial cells …
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Modelling cardiopulmonary interactions. Towards anatomically detailed and physiologically accurate cardiorespiratory models
… physiological mechanisms that regulate the cardiovascular and respiratory systems and their interactions, due to the increasing healthcare burden related to cardiorespiratory diseases. To this end, physiologically accurate mathematical and computational models can provide an effective tool for the …
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Multi-modal molecular imaging of radiation therapy response in the tumour vascular microenvironment
… therapy based on changes in the tumour vascular architecture and blood oxygen saturation, which are closely linked to tumour hypoxia. Given the strong relationship between hypoxia and radioresistance, PAI assessment of the tumour vascular microenvironment has the potential to detect …
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Vascular Network Formation via 3D Printing and Cell-Based Approaches
Vascularization is essential for living tissue and remains a major challenge in the field of tissue engineering. A lack of a perfusable channel network within a large and densely populated tissue engineered construct leads to necrotic core formation, preventing fabrication of functional tissues and …
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