Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Vascular disrupting agents."”.
-
Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
… to come. In the field of anticancer research, vascular disrupting agents (VDAs) that preferentially target the tumor vasculature show great promise. The naturally occurring combretastatins, especially combretastatin A-4 (CA4) and combretastatin A-1 (CA1), in suitable prodrug form, have proven …
-
Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
… as both potent cytotoxins (antiproliferative agents) and effective vascular disrupting agents (VDAs). Our previous studies led to the discovery of a potent inhibitor of tubulin polymerization and cancer cell growth, OXi8006, and its water-soluble phosphate prodrug salt, OXi8007, which …
-
Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
… validated for use in preclinical evaluation of vascular disrupting agents, a new generation of cancer therapeutic. This study demonstrates that despite the dynamic and variable nature of fluorescent and bioluminescent imaging, reproducible results can be obtained if appropriate precautions are …
-
A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… process of induced blood vessel sprouting and vascularisation are essential for the growth and progression of solid tumours. Recruitment of blood vessels is also an important step of the metastatic cascade that enables development of macrometastasis and growth to secondary tumours. Thus, …
-
Design and synthesis of benzosuberene and tetracyclic-based molecules inspired by natural products as inhibitors of tubulin polymerization and preparation of drug-linker constructs to facilitate tumor selective targeted delivery.
… facilitate selective delivery of therapeutic agents to tumors and the tumor microenvironment. The tubulin-microtubule protein has been established as a prime target for anti-cancer agents specifically with inhibitors of tubulin polymerization finding significant clinical relevance. Natural …
-
Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
Vascular disruption is an innovative method for treating cancer. By selectively altering the endothelial cells of tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin (CA) family of small molecules has shown great effectiveness as vascular …
-
Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… A class of small-molecules, referred to as vascular disrupting agents (VDAs), affect the tubulin dynamics of endothelial cells lining tumor-associated blood vessels. Tubulin depolymerization causes the endothelial cells to change shape and detach from the vessel wall leading to vessel …
-
Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
… necrosis 24 h following PEM treatment. Vascular effects and polymersome distribution were studied in 4T1 window chamber tumors. Following i.v. treatment with PEMs, intravital microscopy was used to image polymersome fluorescence, brightfield transmission was imaged for vessel morphology …