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Showing 1 to 13 of 13 for “"Vascular calcification"”.
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Runx2 and Vascular Calcification
Complications arising from vascular calcification, the inappropriate deposition of calcium phosphate crystals in the vasculature, have become more evident in recent years as human longevity has increased. Arterial calcification is frequently categorized as two types, depending on where it occurs: …
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THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… Patients with CKD have an increased cardiovascular risk, mostly due to vascular calcification (VC). By now, it’s quite clear how, in vitro and in vivo, vascular smooth muscle cells (VSMCs) actively participate to VC. In contrast to the wide studies on VSMCs, the role of endothelial cells …
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Molecular Regulation of Vascular Calcification In Murine Models of Atherosclerosis
<p><strong>Background</strong>: Calcification occurs often in the atherosclerotic lesions of patients with coronary heart disease and animals with hypercholesterolemia, such as apolipoprotein-E deficient (ApoE-/-) mice. However, the mechanism(s) underlying the development of calcification in …
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The role of lipoproteins in vascular calcification and plaque stabilisation
Vascular calcification (VC) is a feature of atherosclerotic plaques and is associated with co-morbidities such as diabetes and chronic kidney disease. While its presence is used by cardiologists to identify higher risk patients, increasing data suggests that the morphology of calcification is also …
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Vascular calcification as a risk factor for peripheral arterial disease and its effects on angiogenesis
… PAD is characterised by accelerated arterial calcification and impairment in angiogenesis, both of which associate with adverse cardiovascular outcomes. The pathogenesis of lower extremity PAD remains poorly described but is regarded secondary to atherosclerosis due to fatty plaque build-up …
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The impact of vascular calcification among dialysis dependent South African CKD patients. A five year follow up study. Cardiovascular mortality and morbidity, ethnic variation and hemodynamic correlates
BACKGROUND Vascular calcification is a major risk factor for cardiovascular morbidity and mortality in patients with end stage renal disease (ESRD). In Western countries, Blacks with ESRD appear to have lesser degrees of vascular calcification compared to non-Blacks. However, there is no published …
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The impact of vascular calcification on ambulatory and central aortic blood pressure in a South African dwelling dialysis population : a clinical, radiological and pathophysiological study of vascular health in a young prevalent dialysis population in a developing country
In Sub-Saharan Africa, the prevalence of vascular calcification (VC) in CKD-5D is unknown. We undertook to determine the effect of ethnicity on VC, the risk factors for VC, the utility of abdominal X-ray (AXR) in predicting coronary calcium score (CCS) and the effect of VC on central aortic …
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Characterizing the Development of Secondary Hyperparathyroidism and Vitamin D Resistance in Experimental Chronic Kidney Disease
… of calcitriol resistance and increased vascular calcification. Modifications to the PTG that hinder its sensitivity to calcium (Ca) and PO4 are hypothesized to be involved in the development of calcitriol resistance, renal osteodystrophy, and vascular calcification in SHPT which is …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… stiffness sensing and how this influences vascular smooth muscle cell (VSMC) calcification. In the first study, experiments in primary murine Ddr1+/+ or Ddr1-/- VSMCs revealed that DDR1 promotes VSMC calcification in a stiffness-dependent manner by a positive feedback loop between DDR1 and …
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Papel das calcificações vasculares mamárias na predição do risco cardiovascular
Cardiovascular diseases (CVD) are the leading cause of death worldwide, constituting one-third of all deaths in women. Carriers of coronary artery disease (CAD) presented a silent evolution, so it is important to identify those who present the highest risk of developing events. Clinical scores …
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The effect of vitamin K On vascular health and physical function in older people with vascular disease
… and expense on health and social care. Cardiovascular disease, prevalent in older people, goes hand in hand with declining physical function and new ways of tackling the burden this places on older persons, their carers and health services are required.<br/><br/>Recent work has suggested that …
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Serum Osteoprotegerin, a Potential Novel Marker of Systemic Inflammation: The Influence of Obesity, Insulin Sensitivity and Oral Glucose Loading on its Circulating Concentrations
… the presence of type 2 diabetes, severity of vascular calcification and coronary artery disease. Obesity is a risk factor for diabetes and cardiovascular disease but little is known about the impact of body weight on circulating OPG. The purpose of these experiments was to evaluate the impact …
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Measurement and Applicants of Incidental Coronary Calcium on Chest CT Scans
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.