Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Vascular biology"”.
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Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia
… cell (EPC) number are established indicators of vascular pathology and prognosis.
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Optical-Resolution Photoacoustic Microscopy
… in fields such as neurology, ophthalmology, vascular biology, and dermatology. My doctoral research focuses on developments and biomedical applications of OR-PAM. The first part of my dissertation discusses the development of three generations of OR-PAM towards high-resolution, …
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The Roles of Primary Cilia in Cardiovascular Diseases and Cancer
… mental retardation, and obesity to cardiovascular diseases. Dysfunction in endothelial cilia contributes to aberrant fluid-sensing and results in vascular disorders, such as hypertension, aneurysm, and atherosclerosis. In this dissertation, the most recent outcomes on the roles of …
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Plasma nitrite reserve and vascular function before and after handgrip training in patients with heart failure
There is a direct relationship between vascular health and physical function. The controllers of this relationship are unclear, but appear to involve biomechanical and biochemical influences on the vascular wall. Purpose: The purpose of this dissertation was twofold: (1) to explore the relationship …
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Single cell transcriptomics of the retinal vascular endothelium in health and diabetes
… play vital roles in angiogenesis and microvascular barrier formation and are supported by retinal mural cells. When these cells become dysfunctional during diabetes, they can lead to sight threatening complications such as diabetic retinopathy (DR) and diabetic macular oedema (DMO). Gene …
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A Single Cell and Spatial Transcriptomic Investigation of Traumatic Brain Injury: Novel insights into endothelial-derived Eph signaling
A staggering number of injury related disabilities and deaths are connected to traumatic brain injury (TBI) worldwide. Traumatic brain injury (TBI) involves an intricate and multifaceted cascade of events, starting with an initial mechanical impact followed by secondary injury brought on by …
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Shp2 Regulates Vascular Endothelial Matrix Degradation in Phosphatase-Independent Manner
Shp2 is a protein tyrosine phosphatase that is implicated in many diseases such as developmental disorders and cancers. One of its suggested physiological functions is regulation of angiogenesis, which is often impacted in Shp2 pathologies. However, its role in angiogenesis is still poorly …
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Mechanisms of Western-Diet Induced Endothelial Stiffening: Endothelial CD36 and Long-Chain Fatty Acids
… WD is known to be detrimental to cardiovascular health. These studies present novel insights into the mechanism undergirding WD-associated cardiovascular dysfunction: stiffening (an increase in the elastic modulus) of the aortic endothelial layer associates with barrier disruption, and …
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Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease
… and systemic atherosclerosis. Recent advances in vascular biology proposed a role of inflammatory and haemostatic mechanisms in atherosclerotic disease. Although inflammatory and haemostatic markers have been associated with coronary atherosclerosis in large scale epidemiological studies their …
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… cell adhesion molecules, etc. that promote vascular inflammation. Due in part to thrombin and other pro-atherogenic molecules, this prolonged inflammatory state in atherosclerosis results in the deterioration of the endothelium, increasing the risk of focal thrombosis. Current treatment …
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… EC senescence leads to abnormal proliferation of vascular smooth muscle cells, reduced vasoreactivity, enhanced vascular permeability, and greater adhesion of circulating monocytes and lipids. Endothelial senescence often occurs coincident with an inflammatory response within the endothelium. …
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
… and maintenance of an efficient and functional vascular transport system. As such, endothelial dysfunction can result in the development of tissue ischaemia and has been highlighted as a major step in the development of various degenerative diseases that affect the micro and macro vasculature …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
<p>Cancer and vascular disease are the two most predominant causes of mortality in the United States. Potential regulatory mechanisms for these two diseases have consumed research interests. Tetraspanins are cell surface proteins that organize the cell membrane. Cellular membrane organization is a …
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INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… receptors plays an important role also in the biology of several host cell types, with a particular focus on endothelial cell migration, proliferation and survival. Therefore, integrins act as molecular bridges between the extracellular matrix and the cytoskeleton, displaying mechanical …
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Multi-modal molecular imaging of radiation therapy response in the tumour vascular microenvironment
… therapy based on changes in the tumour vascular architecture and blood oxygen saturation, which are closely linked to tumour hypoxia. Given the strong relationship between hypoxia and radioresistance, PAI assessment of the tumour vascular microenvironment has the potential to detect …
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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes
… Hypertension increases risk of major cardiovascular and cerebrovascular events, such as stroke and mental dysfunction. During hypertension, cerebral arteries have high myogenic tone and are less responsive to vasodilators, including nitric oxide (NO). The regulation of arterial contractility …
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Mechanism of Rare Variant In Acta2, P.Arg149Cys, Driving Diverse Vascular Disease
<p>Heterozygous variants in <em>ACTA2</em> (smooth muscle (SM) α-actin) predispose to thoracic aortic aneurysms and dissections (TAAD) and early-onset coronary artery disease (CAD). The most common <em>ACTA2</em> mutation is a genetic alteration of arginine 149 to a cysteine, <em>ACTA2</em> …