Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Vascular Stability"”.
-
The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… exact mechanism by which BMP9 regulates vessel stability is unknown, but BMP9 is known to inhibit pro-angiogenic VEGF signalling. A microarray study conducted by the Morrell group in pulmonary artery endothelial cells after treatment with BMP9 revealed Semaphorin 3G (SEMA3G) as a potential …
-
HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish
… genes and mechanisms implicated in cerebral-vascular malformations are unknown. Treatment options remain ineffective. With the present models, the pathophysiological consequences of ICH can only be assessed in situ and after histological analysis. Furthermore, common deficiencies of the …
-
CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension
… However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. We observed that CD151 is required for the maintenance of endothelial capillary-like structures formed in vitro and the integrity of lung endothelial cell-cell …
-
Recombinant Hemoglobin Variants: Structure-Function Analysis and Oxygen Therapeutic Design
… a rat model each protein exhibited an increased vascular lifetime and no renal excretion. Furthermore, a dose dependent increase in vascular lifetime was observed suggesting that the protein clearance mechanism is saturatable. These circularly permuted variants represent the first recombinantly …
-
The use of small molecules to illuminate vascular development
Development of the vascular system is a multifactorial process. Its proper establishment has a big impact on life. Not only is this process essential for organismal growth but abnormal blood vessel formation leads to several pathologies. In some cases the disease itself triggers changes to the …
-
Integrin-independent activation of Tie2 using the de novo designed protein H8mb
… signaling axis is a central regulator of vascular stability, yetefforts to harness it therapeutically have been limited by the poor developability and receptor promiscuity of Angiopoietin-1 (Ang1), which binds both Tie2 and α5β1 integrin. Here we report the de novo design of a compact Tie2 …
-
A vascular imaging system for longitudinal registration and mapping of superficial vessels with quantitative analysis
… the peripheral arterial disease, assessment of revascularization during surgical interventions, and early assessment of skin cancer from melanoma imagery. Some non-clinical applications include biometric scanning and relocalization for ultrasound imaging. To bridge the knowledge gap between the …
-
Pericyte deficiencies in a foxf2 loss of function mutant
Pericytes are critical players in vascular development and disease but are not widely studied in the context of cerebral small vessel disease, a vascular condition related to stroke that progressively weakens brain microvessels. Foxf2, a pericyte-expressed gene, is involved in vascular stability …