Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Vascular Smooth Muscle Cell"”.
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… factor which shows increased activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… as a new lumen narrowing at the site of previous vascular reconstruction, affects millions of patients each year worldwide. Restenosis has been a major limitation of surgical and endovascular reconstructions since their inception and while decades of research have yielded improved results for …
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
Cardiovascular disease (CVD) is the primary cause of death in the United States and worldwide. Localized extracellular acidosis has been theorized as a possible contributor to CVD pathogenesis, but its precise impact remains unclear. G protein coupled receptors (GPCRs) are seven transmembrane …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
… studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a crucial developmental process regulating angiogenesis and vasculogenesis, with phenotypic modulation of SMC …
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Regulation of vascular smooth muscle cell function by mechanical strain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
Vascular smooth muscle cells (VSMCs) possess a remarkable capacity to change phenotype in response to injury or inflammation. In healthy arteries, VSMCs exist in a contractile state, but upon vascular inflammation or injury, they can switch into an activated state, in which they downregulate the …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… all’età, caratterizzata dall’accumulo di cellule senescenti, in particolare di cellule muscolari lisce vascolari (VSMC). Queste cellule, pur mantenendo un’attività metabolica, mostrano importanti alterazioni morfologiche, disfunzioni mitocondriali e adottano un fenotipo secretorio …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
Phenotypic plasticity of human arterial smooth muscle cells (HASMCs) allows them to transition from a “contractile/quiescent” state, in which they regulate arterial tone and blood pressure, to one in which these cells are more “synthetic/activated”. Synthetic/activated HASMCs are migratory and …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… in these families is <em>ACTA2</em>, encoding smooth muscle-specific α-actin. <em>ACTA2</em> missense mutations predispose individuals both to TAAD and to vascular occlusive disease of small, muscular arteries.</p> <p>Mice carrying an <em>Acta2 </em>R258C mutant transgene with a wildtype …
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Effects of cytokines and monocytes on matrix metalloproteinases in human vascular smooth muscle cell cultures
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1995.
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
Mechanotransduction is the process by which extracellular physical cues are converted into intracellular biochemical responses. The stiffness of the matrix influences numerous processes such as cell differentiation, cell migration, fibrosis, and tumorigenesis. Stiffness is sensed by matrix-binding …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
… been thought to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aortic stiffness, a reconstituted aortic tissue model (composed of vascular smooth muscle cells (VSMCs) in a collagen matrix) was …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
Widespread changes in gene expression accompany vascular smooth muscle cell (VSMC) phenotypic switching, a hallmark of vascular disease. Upon insult, VSMCs downregulate contractile proteins and upregulate genes linked to vascular remodelling, such as matrix metalloproteinases (MMPs) and …
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Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease
Deregulation of vascular smooth muscle cell (VSMC) phenotypic switching is implicated in vascular disease development and VSMCs produce the majority of cells in late-stage atherosclerotic plaques. However, VSMC accumulation in mouse models of vascular disease arises from clonal expansion of very …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
Introduction: Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and display phenotypic plasticity that influences both plaque growth and stability. The fibrous cap, a stabilising feature of plaques, contains an abundance of VSMC-derived cells. However, the cellular …
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Inhibition of Vascular Smooth Muscle Cell Migration and Intimal Thickening with Chimeric N-Cadherin Mimetic Peptides: Development of a Novel Therapeutic Strategy for Restenosis
… side effects of restenosis (re-narrowing) from smooth muscle cell (SMC) migration and proliferation, and late thrombosis due to endothelial cell (EC) death from indiscriminately cytotoxic chemotherapeutic agents. We developed a chimeric peptide with a mimetic domain for neural (N)-cadherin and a …
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