Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Vascular Risk"”.
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Vascular Risk, Functional Connectivity, and Episodic Memory in Older Adults
… which is associated with memory impairment. Vascular risk may be an important contributor to age-related DMN disruption through its effects on gray and white matter integrity.</p><p>The present study examined relationships among vascular risk, DMN FC, and episodic memory in older adults using …
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Vascular risk and depression in outpatients at Groote Schuur Hospital memory clinic
… for mood regulation. Such evidence of vascular disease has in turn been associated with vascular risk factors such as diabetes, hypertension, smoking, high cholesterol and heart disease. The vascular depression hypothesis (Alexopoulos et al., 1997) proposes that individuals with …
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The role of a nurse-led vascular risk reduction clinic in diabetes care
… Aims Type 2 diabetes is characterised by excess vascular morbidity and mortality. Intensive vascular risk reduction in type 2 diabetes patients with microalbuminuria has been shown to significantly reduce future vascular events by 50%. The aim of this research was to determine whether an …
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Changes In Cerebral White Matter, Vascular Risk And Cognition Across The Adult Lifespan
… of hypertension treatment, a common marker of vascular risk. A sample of 96 healthy participants spanning the adult lifespan underwent DTI scanning and cognitive testing at baseline and following a two-year delay. Univariate LDM analyses showed cross-sectional associations between DTI measures …
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The impact of a single brief intervention versus multiple contact lifestyle intervention on change in body weight and modifiable cardio vascular risk factors in adults who have undertaken cardiovascular risk screening
… hypertension, hyperlipideamia (which is a major risk factor for ischemic heart disease), cardiovascular diseases (CVD) and certain cancers. CVD relates strongly to lifestyles, and risk factor modifications have been shown to reduce mortality and morbidity. It has become clear that the major …
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The Relationship of Inflammatory Markers to Cognitive Function in a Population-Based Sample
… to play critical roles in atherosclerosis and vascular disease, and have been linked to Alzheimer’s Disease, vascular dementia, and subclinical levels of cognitive decline. The present study investigated the relationship of these four inflammatory markers to cognitive function prospectively, …
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Screening for Proteinopathic-related Dementias in Low-resource Clinical Contexts: A Machine Learning Approach
… variables (neuropsychological test data and vascular risk factor information) required for accurate classification of PRDs in an older adult sample from an LMIC population and to derive a decision tree algorithm that diagnoses these types of dementias. Methods: The present study used data …
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Inflammatory markers as novel predictors of cardiovascular disease
… contributing factor in atherogenesis and the risk of atherothrombotic complications. Baseline measurements of some inflammatory markers are known to be predictive risk factors for future cardiovascular disease (CVD) events in prospective epidemiological studies. Inflammatory markers dominant …
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Cardiovascular diseases, risk factors and cognitive decline in the general population
… diseases and related factors, including cardiovascular diseases (CVDs) and vascular risk factors. Cognitive decline has been an understudied outcome in cardiovascular epidemiological research. Few reports have comprehensively examined cognitive function in relation to clinical manifestations of …
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Oxidative stress biomarkers in dementia
… that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. The thesis aimed to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated using both hypothesis …
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Life after stroke: ‘a life I like’ and ‘a life to live’.
… knowledge and health behaviour change to reduce vascular risk after stroke and In the same boat – the benefits of peer support for stroke survivors and caregivers. These themes were used to select relevant standardised validated tools; the Stroke Knowledge Test (SKT), Stroke Self Efficacy …
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Diffusion Tensor Imaging and Cognition of Transient Ischemic Attack Patients and Healthy Controls
… need to be redesigned with a focus on high-risk population and standardized biomarkers, which include clinical, demographic, imaging and neuropsychological considerations. Transient Ischemic Attack (TIA) patients are at an increased risk of dementia due to the presence of vascular risk …
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Delay in accessing healthcare after transient ischaemic attack and minor stroke : the role of primary care in the problem and the solution
… and minor stroke are associated with a high risk of recurrent stroke which can be predicted with a clinical rule and reduced with urgent treatment. Delay in accessing assessment and vascular risk factor modification should therefore be as short as possible, yet little is known in the UK about …
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Characterization and Differences Between Possible and Probable Mild Cognitive Impairment
… designed to compare the cognitive features and risk factors of AD in subgroups of patients with SMCs with (Probable MCI) and without (Possible MCI) objective memory deficits in relation to controls. It is predicted that the Probable MCI group will demonstrate lower performance and have a greater …
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The distinct contributions of cardiovascular risk factors to cognitive ageing
… is not clear whether different aspects of cardiovascular health – such as blood pressure or heart rate – affect the brain through shared or independent pathways, partly because they are often condensed into a single composite score or examined in isolation. The research reported in the following …
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ARTERIAL STIFFNESS AND CEREBRAL BLOOD FLOW AMONG OLDER ADULTS
… these trends will continue unabated. Targeting vascular risk factors is proposed as a critical means to prevent AD and related dementias; however, few targets for intervention remain. A previous unpublished study examining the Piedmont Aging, Cognition, & Exercise Study (PACE) cohort found a …
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Mixed Dementia Induced by Right Common Carotid Artery Occlusion in an Alzheimer Mouse Model
Although vascular risk factors are associated with Alzheimer disease (AD), the effect of chronic cerebral hypoperfusion (CCH) on the progression of AD has not been widely evaluated. We aimed to evaluate whether CCH would aggravate the behavioral changes and plaque formation in an AD transgenic (Tg) …
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Distinct contribution of white matter damage to the clinical syndrome of Alzheimer's disease
… in non-demented individuals. WML are of presumed vascular origin because they show features of small-vessel disease and are more prevalent in individuals with vascular risk. It is currently unclear whether WML are linked to the neurodegenerative pathologies of Alzheimer's disease or are an …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… arise from genetic or lifestyle factors and that vascular dysfunction and inflammation play a role in the progression of the disease. Many cardiovascular factors associated with an increase in systemic infection have been linked to a risk of AD development and progression. However, the link …
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Sporadic cerebral small vessel disease and cognitive abilities
… small vessel disease (SVD) is a leading cause of vascular cognitive impairment, contributing to multiple neurological disorders ranging from stroke, to mild cognitive impairment and dementia. However, despite a huge number of studies on the subject, we have a limited understanding of how SVD …
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