Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Vascular Network"”.
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VEGFR-3 and Tie pathways in vascular network formation
The blood and lymphatic vascular systems are essential for life, but they may become harnessed for sinister purposes in pathological conditions. For example, tumors learn to grow a network of blood vessels (angiogenesis), securing a source of oxygen and nutrients for sustained growth. On the other …
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Algorithmic generation of vascular network models for additive manufacturing
Fabrication of functional vascularised three-dimensional tissue constructs has been a long-standing objective in the field of tissue engineering. Currently, the main limitation in this field is the inability to produce fully vascularised tissue with an internal mass transport system (vascular …
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Vascular Network Formation via 3D Printing and Cell-Based Approaches
Vascularization is essential for living tissue and remains a major challenge in the field of tissue engineering. A lack of a perfusable channel network within a large and densely populated tissue engineered construct leads to necrotic core formation, preventing fabrication of functional tissues and …
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Fractal vasculature and vascular network growth modeling in normal and tumor tissue
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Semi-Automated Reconstruction of Vascular Networks in Knife-Edge Scanning Microscope Mouse Brain Data
… be used in the reconstruction of neuronal and vascular structures in the mouse brain. Tracing the vascular network of the brain and reconstructing the topology allows us to map the circulatory pathways inside the brain. Studying these cerebro-vascular networks is important to understand and …
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Directed Assembly of Three-Dimensional Microvascular Networks
The construction of 3-D microvascular networks enables microfluidic devices with unparallel geometric complexity. In one example, a 3-D microfluidic mixing device was demonstrated with square-spiral mixing towers isolated within the vascular network by a secondary photopatterning process. These …
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Engineering polymer biomaterial interfaces for promoting cellular morphogenesis
… synthetic ECMs that support the generation of vascular network structures in dense tissue environments represent a path towards overcoming the limitations of existing model systems.
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Modulating tissue mechanics to increase oxygen delivery to tumors
… slows blood flow partly by reducing the intravascular pressure drop. Strategies to repair leakiness towards decreasing hypoxia exist, so I developed approaches for overcoming compression. In order to understand the origin of vessel compression, we developed the first ex vivo technique to …
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Astrocyte and vascular changes contribute to Alzheimer's disease
… This dissertation examines astrocyte and vascular changes in AD using a well-described preclinical AD mouse model: hAPPJ20 mice. First, a multi-omics analysis of cortical astrocyte gene and protein expression was conducted at 3, 6, 12, and 18 months in female J20 and wild-type (WT) mice, …
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Comprehensive geometric modeling of human cerebral vasculature for quantitative vascular analysis
… geometric representation of the interconnected vascular network as a framework. We then described an image processing pipeline for the segmentation of vascular anatomy from discrete scalar field images, and applied the pipeline to segment the anatomical structures of cerebral vasculatures from …
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Origins of Systemic to Pulmonary Collateral Arteries and their Relative Frequencies in Patients with Pulmonary Artery Atresia or Stenosis as determined using Multidetector Computed Tomography Angiography
… is accurate and comprehensive knowledge of the vascular network supplying the lungs. This vascular network can be exceedingly complex as it may include a wide variation of systemic to pulmonary collateral arteries (SPC/s). AIM: This study aims to guide radiologists, cardiologists and …
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Mechanisms underlying establishment and maintenance of pregnancy
… are followed by the formation of an extensive vascular network in the stroma that supports embryonic growth and ensures successful implantation. Interestingly, in many mammalian species, these processes of early pregnancy occur in a hypoxic environment. However, the mechanisms underlying …
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Anti-Angiogenic Therapy in Non-Small Cell Lung Cancer: Characterizing a New Therapy and Investigating Potential Mechanisms of Resistance
… development of blood vessels from a pre-existing vascular network. This process is essential during growth, development and wound healing and plays a critical role in the growth and progression of cancer. Initial tumor size is restricted by the diffusion capacity of oxygen and nutrients from …
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Stimulating angiogenesis into biomaterials through the delivery of growth factors
… as ePTFE. Long term patency of small diameter vascular grafts used for infra-inguinal reconstructions, however, is below 50 % 5 years after implantation. Therefore, novel vascular graft concepts and materials are needed. The concept of transmural in vivo endothelialisation of vascular grafts …
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Engineering biomaterial surfaces with N-cadherin
… angiogenic factor secretion, and neural network formation. First, cell-cell adhesion was reproduced by tethering the recombinant N-Cadherin to hydrogel surfaces (Chapter 2). Second, soluble N-Cadherin was introduced into clusters of bone marrow stromal cells (BMSCs) to examine their …
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Extracellular Matrix Contributions to Early Vascular Development and Pericyte Precursor Dynamics
… from the body. The formation of a functioning vascular system depends on the close coordination of many cell types and, on the capillary level, specifically endothelial cells and pericytes as well as the surrounding protein microenvironment, known as the extracellular matrix (ECM). Impaired …
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Development of an endometrial inspired biomaterial
… Unlike native tissue which contains a dense vascular network to provide nutrients and eliminate waste, biomaterials rely solely on diffusive transport which is often insufficient at maintaining cellular behavior of implants, diminishing their efficacy. Many strategies seek to prevascularize …
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A Low-cost Microvascular Phantom for Photoacoustic Imaging Using Loofah
… are inadequate for mimicking the complex microvascular structures found in human tissue due to their inability to replicate varying sizes and distri- butions of vasculature. This limitation underscores the need for a new material capable of replicating intricate microvascular networks. In this …
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… the tumor and organized to form a blood vessel network de novo, is essential for the growth of Ewing’s sarcoma. We further demonstrated that these bone marrow cells differentiate into pericytes/vascular smooth muscle cells(vSMC) and contribute to the formation of the functional vascular network. …
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Role of JunB in hypoxia-mediated cell response and tumour angiogenesis
… Analysis of junB-/- EBs revealed that vascular defects of JunB null embryos can be mimicked by this in vitro system in that these EBs fail to form a higher organised vascular network and exhibit a strongly reduced VEGFR-1 expression, both reflecting the phenotype described for yolk sacs …
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