Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Vascular Leak Syndrome"”.
-
Cd44-Hyaluronic Acid Interactions in Il-2 Induced Vascular Leak Syndrome
… by severe toxicity leading to development of vascular leak syndrome (VLS). Previous studies from our laboratory demonstrated that CD44 knockout mice exhibit marked decrease in IL-2 induced VLS, thereby suggesting a role for CD44 in VLS. In the current study we tested whether use of mAbs …
-
Role of CD44 in Immune Functions and Endothelial Cell Injury
… of B cells. Endothelial cell injury resulting in vascular leak syndrome (VLS) is one of the most widely noted phenomenons in a variety of clinical diseases, however, the underlying reason for which remains unclear. We used interleukin-2 induced VLS as a model to investigate the role of cytolytic …
-
Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy
… toxicities of IL2-based products is vascular leak syndrome (VLS), leading to generalized edema and organ failure, which could be fully recapitulated in our in vivo model. Upadacitinib spared healthy organs from VLS manifestations and allowed the administration of curative doses of …