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Showing 1 to 20 of 37 for “"Vascular Grafts"”.
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Electrospun Tissue Engineered Vascular Grafts
ePTFE and Dacron vascular grafts are successful in large diameter applications but provide poor outcomes in small diameter (<6 mm) applications. Occlusion, poor cell ingrowth and a mismatch of compliance compared to the native vessel, cause failure to the current synthetic grafts. Spontaneous …
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Electrospun Tissue Engineered Vascular Grafts
ePTFE and Dacron vascular grafts are successful in large diameter applications but provide poor outcomes in small diameter (<6 mm) applications. Occlusion, poor cell ingrowth and a mismatch of compliance compared to the native vessel, cause failure to the current synthetic grafts. Spontaneous …
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
Electrospun Tissue Engineered Vascular Grafts (TEVG) have been synthesized with variable success. TEVG ≤5mm in diameter have had limited success due to poor patency outcomes with high rates of restenosis secondary to a phenomenon called Intimal Hyperplasia (IH). We have performed previous animal …
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Nanoscale properties of poly(ethylene terephthalate) vascular grafts
Vascular grafts are prosthetic tubes that serve as artificial replacements for damaged blood vessels. Poly(ethylene-terephthalate), PET, has been successfully used in large diameter grafts; however, small caliber grafts are still a major challenge in biomaterials. Due to surface forces, blood …
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Stabilised decellularised vascular grafts in an ovine carotid model
… is an urgent clinical need for an alternative vascular graft, especially for smaller artery applications such as in below-knee and coronary artery bypass. Currently available synthetic grafts have unacceptably low patency rates, while autologous saphenous vein grafts are not feasible in one …
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Fluid Dynamic Assessments of Spiral Flow Induced by Vascular Grafts
Peripheral vascular grafts are used for the treatment of peripheral arterial disease and arteriovenous grafts for vascular access in end stage renal disease. The development of neo-intimal hyperplasia and thrombosis in the distal anastomosis remains the main reason for occlusion in that region. The …
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Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
Cardiovascular disease is the leading cause of mortality and morbidity in the United States and other developed countries. In the United States alone, 8 million people are diagnosed with peripheral arterial disease per year and over 250,000 patients have coronary bypass surgery each year. …
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Near-Field Electrospinning and Characterization of Biodegradable Small Diameter Vascular Grafts
… small-diameter (< 6 mm inner diameter (ID)) vascular graft hinges on designing a template that facilitates transmural ingrowth of capillaries to regenerate an endothelized neointimal surface. Previous traditionally electrospun (TES) approaches to create bioresorbable vascular grafts lack the …
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Ultrasonography Evaluation of Patency of Implanted Infra-Renal Vascular Grafts in the Rat Model.
… decades has resulted in minimal improvement in vascular graft development. Small animal models are the first line of species exposed to vascular graft implantation and invasive monitoring of experimental graft patency may contribute to pain, suffering, higher cost and earlier sacrifice. …
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Design of an adventitial type reinforcement of prosthetic vascular grafts through mechanically affirmed material and structure modulation
The high occurrence of vascular disease in the 20th century has been the driving force for researchers to produce a successful small diameter synthetic graft. Large diameter synthetic grafts remain patent for extended periods due to high flow rate, while smaller diameter grafts occlude more …
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REGENERATION OF ELECTROSPUN BIORESORBABLE VASCULAR GRAFTS: A PHENOMENON ASSOCIATED WITH VASCULAR GRAFT PROPERTIES AND MACROPHAGE PHENOTYPES (M1/M2)
… important to further our knowledge about in situ vascular prosthetic regeneration. The adhesion, proliferation and cytokine secretion of bone marrow derived murine mast cells (BMMC) on electrospun polydioxanone (PDO), polycaprolactone (PCL) and silk scaffolds, as well as tissue culture plastic …
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Modulation of Endothelial Cell Adhesion to Synthetic Vascular Grafts Using Biotinylated Fibronectin in a Dual Ligand Protein System
… Unfortunately, synthetic small diameter vascular grafts have unacceptable patency rates, primarily due to lumenal thrombus formation and intimal thickening. Endothelial cells (EC) mediate the anti-thrombotic activity in healthy blood vessels, and due to the scarcity of suitable autologous …
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In vitro endothelialization of vascular prostheses: a possible means to improve the early patency of small diameter vascular grafts
… unsatisfying performance of synthetic arterial grafts, we attempted to create an endothelium on the prosthetic surface by lining the graft with cultured endothelial cells. To provide sufficient cell-numbers for lining, a rapid and reliable harvest technique had to be developed first. In an …
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The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models
There is a significant need for small diameter vascular grafts to be used in peripheral vascular surgery; however autologous grafts are not always available, synthetic grafts perform poorly and allografts and xenografts degenerate, dilate and calcify after implantation. We hypothesized that …
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Extrusion and evaluation of degradation rate and porosity of small diameter collagen tubes
The limited availability of autografts and failure of small diameter synthetic vascular grafts has stimulated continuing efforts to develop small diameter vascular grafts based on natural materials. The small diameter collagen tubes were extruded using bovine collagen type I. The biodegradation …
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Engineering Biodegradable Vascular Scaffolds for Congenital Heart Disease
… To treat these malformations in a child’s cardiovascular system, synthetic grafts have been used as a primary intervention. However, current grafts suffer from deficiencies such as minimal biological compatibility, inability to grow and adapt, and high failure rates. Additionally, the grafts are …
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High porosity electrospun scaffolds for small diameter vascular graft applications
… critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosity for transmural endothelial in-growth. This study was aimed at …
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Finite element and mechanobiological modelling of vascular devices
There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or tissue engineered blood vessel. The aim of this thesis was to develop computational models that could assist in the design of …
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Tailoring of the biomechanics of tissue-regenerative vascular scaffolds
… of long term patency of small diameter synthetic vascular grafts currently available on the market has directed research towards improving the performance of these grafts. Improved radial compliance matching and appropriate tissue ingrowth into the graft structure are main goals for an ideal …
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Coaxially electrospun heparin-eluting scaffolds for vascular graft application
… use of electrospun scaffolds for small diameter vascular grafts (< 6 mm) has shown promise in the search for alternative solutions, as current synthetic grafts have high failure rates. The inclusion of heparin into such scaffolds can be beneficial for vascular graft applications as it could …
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