Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"Vascular Graft"”.
-
Composite hydrogel-nanofibre vessels for vascular graft applications
A vascular graft should mimic the structure and properties of the native artery which has a layered structure. The media layer of native arteries contributes the main mechanical support to the vessel and the intima layer, lined with endothelial cells, provides a smooth antithrombogenic surface for …
-
Nitric Oxide Releasing Polymers For Vascular Graft Applications
… system, utilization of the system towards vascular graft application was also studied. The idea behind this NO-based therapy was to provide a material that will not only mimic native blood vessels, but would also enable endothelial cell [EC] proliferation, promoted by long-term NO release …
-
Development and investigation of polymeric vascular graft materials
Vascular disease leading to stenotic or occluded arteries and subsequent ischemia is often treated using bypass grafts. Although autologous material, the preferred source for constructing a bypass graft, often provides a graft with satisfactory patency rates, it is not always available and suitable …
-
Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft
… OF A POLYSACCHARIDE DERIVED TISSUE ENGINEERED VASCULAR GRAFT</p> <p>By</p> <p>Irina Robu</p> <p>November 2010</p> <p>Advisor: Dr. Howard Matthew</p> <p>Major: Chemical Engineering</p> <p>Degree: Doctor of Philosophy</p> <p>As the most frequent congenital anomaly and the leading cause of death, …
-
Coaxially electrospun heparin-eluting scaffolds for vascular graft application
… use of electrospun scaffolds for small diameter vascular grafts (< 6 mm) has shown promise in the search for alternative solutions, as current synthetic grafts have high failure rates. The inclusion of heparin into such scaffolds can be beneficial for vascular graft applications as it could …
-
High porosity electrospun scaffolds for small diameter vascular graft applications
… critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosity for transmural endothelial in-growth. This study was aimed at …
-
Design and nondestructive imaging of a bioengineered vascular graft endothelium
Cardiovascular disease is currently the leading cause of death in the U.S. that frequently requires bypass surgery using vascular grafts for treatment. Current limitations with fully synthetic grafts have led researchers to bioengineered alternatives that consist of a combination of vascular …
-
Development of a tissue-regenerative vascular graft: Structural and Mechanical Aspects
In attempt to prevent graft failure, the tissue-regeneration field offered the porous vascular scaffolds as promising solution for the lack of endothelialization seen in the small-calibre synthetic vascular graft. Another cause of graft failure was reported to be the mechanical mismatch between the …
-
Isolating and optimising transmural endothelialization as an independent mode of spontaneous vascular graft healing
… designed animal models with short, non-isolated grafts have led researchers to exclusively investigate transanastomotic endothelialization(TAE), which is known to be limited to the perianastomotic region in humans. Alternative spontaneous forms of endothelialization (fallout and transmural) need …
-
REGENERATION OF ELECTROSPUN BIORESORBABLE VASCULAR GRAFTS: A PHENOMENON ASSOCIATED WITH VASCULAR GRAFT PROPERTIES AND MACROPHAGE PHENOTYPES (M1/M2)
… important to further our knowledge about in situ vascular prosthetic regeneration. The adhesion, proliferation and cytokine secretion of bone marrow derived murine mast cells (BMMC) on electrospun polydioxanone (PDO), polycaprolactone (PCL) and silk scaffolds, as well as tissue culture plastic …
-
Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… hyperplasia are major causes of small diameter vascular conduit (SDVC) failure. The present study was aimed to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with …
-
Cyclic stretch-mediated release of vascular endothelial growth factor by vascular smooth muscle cells : a role in improved vascular graft patency
… phosphorylation in response to cyclic stretch in vascular cells, the effect of cyclic strain on the KDR-mediated endothelial response to locally-released VEGF was also investigated. Low passage number bovine aortic SMC and EC were plated on collagen-coated elastomer plates and subjected to 10% …
-
Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
Cardiovascular disease is the leading cause of mortality and morbidity in the United States and other developed countries. In the United States alone, 8 million people are diagnosed with peripheral arterial disease per year and over 250,000 patients have coronary bypass surgery each year. …
-
Ultrasonography Evaluation of Patency of Implanted Infra-Renal Vascular Grafts in the Rat Model.
… decades has resulted in minimal improvement in vascular graft development. Small animal models are the first line of species exposed to vascular graft implantation and invasive monitoring of experimental graft patency may contribute to pain, suffering, higher cost and earlier sacrifice. …
-
Near-Field Electrospinning and Characterization of Biodegradable Small Diameter Vascular Grafts
… small-diameter (< 6 mm inner diameter (ID)) vascular graft hinges on designing a template that facilitates transmural ingrowth of capillaries to regenerate an endothelized neointimal surface. Previous traditionally electrospun (TES) approaches to create bioresorbable vascular grafts lack the …
-
Fluid Dynamic Assessments of Spiral Flow Induced by Vascular Grafts
Peripheral vascular grafts are used for the treatment of peripheral arterial disease and arteriovenous grafts for vascular access in end stage renal disease. The development of neo-intimal hyperplasia and thrombosis in the distal anastomosis remains the main reason for occlusion in that region. The …
-
Finite element and mechanobiological modelling of vascular devices
There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or tissue engineered blood vessel. The aim of this thesis was to develop computational models that could assist in the design of …
-
FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING
… functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to …
-
Electrospun Tissue Engineered Vascular Grafts
ePTFE and Dacron vascular grafts are successful in large diameter applications but provide poor outcomes in small diameter (<6 mm) applications. Occlusion, poor cell ingrowth and a mismatch of compliance compared to the native vessel, cause failure to the current synthetic grafts. Spontaneous …
-
Electrospun Tissue Engineered Vascular Grafts
ePTFE and Dacron vascular grafts are successful in large diameter applications but provide poor outcomes in small diameter (<6 mm) applications. Occlusion, poor cell ingrowth and a mismatch of compliance compared to the native vessel, cause failure to the current synthetic grafts. Spontaneous …
Page 1 of 2