Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"Vascular Endothelium"”.
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Selective irradiation of the vascular endothelium
… unique methodology to selectively irradiate the vascular endothelium in vivo to better understand the role of vascular damage in causing normal tissue radiation side-effects.The relationship between vascular endothelial cell apoptosis and intestinal crypt stem cell death was evaluated using …
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A mechanical model of vascular endothelium
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1993.
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Biophysical mechanisms of lymphocyte adhesion to activated vascular endothelium
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1998.
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Histone Deacetylase 7 and Transcriptional Regulatory Networks of the Vascular Endothelium
… on HDAC7, a class II HDAC that is expressed in vascular endothelial cells and whose function is essential for the maintenance of vascular integrity during embryogenesis. Mice lacking HDAC7 die by e11.5 with complex cardiovascular malformations including endothelial, vascular smooth muscle, and …
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Heterogeneity in the vascular endothelium enables parallel processing of multiple stimuli
The endothelium is a complex network of cells that lines the entire vasculature and it controls virtually all cardiovascular functions. Changes in the behaviour of endothelial cells underly almost all cardiovascular disease. To regulate cardiovascular function, the endothelium integrates hundreds …
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Single cell transcriptomics of the retinal vascular endothelium in health and diabetes
… play vital roles in angiogenesis and microvascular barrier formation and are supported by retinal mural cells. When these cells become dysfunctional during diabetes, they can lead to sight threatening complications such as diabetic retinopathy (DR) and diabetic macular oedema (DMO). Gene …
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The dynamic response of vascular endothelium to fluid shear stress in vitro
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1983.
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The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… risk factor for the development of a number of vascular diseases including coronary heart disease and stroke. Lp(a) consists of a low-density lipoprotein (LDL)-like moiety and an unique glycoprotein, apolipoprotein(a) (apo(a)), that is covalently attached to the apolipoproteinB-100 (apoB-100) …
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Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium
Cardiovascular disease (CVD) including atherosclerosis is the leading cause of illness and death in the United States. The American Heart Association indicated that an estimated 81,100,000 American adults have one or more types of CVD and the estimated direct and indirect cost of CVD for 2010 is …
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A Systems-Based Approach to Examine the Molecular Basis of Interactions between Human Monocytes and Human Micro-Vascular Endothelium
… between monocytes of different subsets and the endothelium during different kinds of locomotion. A multi-step, systems-based approach was taken. First, analysis of macro- and micro-vascular endothelium by flow cytometry revealed differences in the cell surface expression of a range of …
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The effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on oxidative and hypoxic stress in the vascular endothelium
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) improve endothelial cell (EC) function by enhancing the synthesis of Nitric Oxide (NO) and attenuating the endothelial leucocyte interaction and platelet aggregation. However the effects of statins on endothelial cell …
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Role of ET-1 and its receptors in the impairment of vascular functions in the cardiomyopathic hamster
… the difference depends on the presence of the vascular endothelium. We also wanted to verify if the contribution of ET-1 receptors (ET[indice inférieur A] and/or ET[indice inférieur B]) in the vascular endothelium and vascular smooth muscle cells (VSMCs) undergoes changes during the development …
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Coregulatory Transcription Factors and Spermatogenesis
… CLD5 expression was ETV5 independent in vascular endothelium; and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli cell CLD5 has a role in BTB function, but also a non-tight junction role in spermatogonia.
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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
… CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that bind specific receptors termed …
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Using single cell transcriptomics to characterise endothelial populations in embryonic haematopoiesis
… endothelial precursor termed haemogenic endothelium during a narrow window of development. This project was undertaken to better characterise endothelial populations in embryonic haematopoietic tissues in an effort to improve our understanding of the endothelial to haematopoietic …
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Microviscometric Analysis of Microvascular Hemodynamics in Vivo
… an accuracy and detail unprecedented in microvascular research. Microviscometry depends only upon knowledge of the velocity profile over the cross section of a microvessel, which can readily be extracted using fluorescent micro-particle image velocimetry (mu-PIV) from distributions in the …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… in response to mechanical perturbations. The vascular endothelium forms a natural barrier between blood and tissues and its disruption leads to blood leakage and serious pathological consequences. VE-cadherin—the primary adhesion molecule at cell-cell junctions in vascular endothelial …
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Mathematical models for interendothelial cleft
Vascular endothelium is the principal barrier to, and regulator of, material exchange between circulating blood and the body tissues. Based on previous research in this field, two new theoretical models have been developed in this thesis. One is to investigate structural mechanisms in the …
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A microvillus based approach to model cell rolling
… which allows leukocytes to attach to activated vascular endothelium and reach sites of inflammation. A novel approach to model cell rolling is presented in this thesis. The model incorporates all the aspects known to be important to rolling in a semi-analytical framework making it …
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Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia
… patients and patients with a history of cerebrovascular disease. However, it is unknown whether this reduction in incidence is a result of the drug, which reduces low-density lipoprotein levels in the blood, or to statins’ pleotropic effects on the vascular endothelium. Since their discovery, …
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