Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Vascular Endothelial Growth Factor A"”.
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Expression of Vascular Endothelial Growth Factor-A and its Receptors in Uteroplacental Tissues of the Normotensive and Hypertensive Pregnant Rat
… leading to preeclampsia and fetal intrauterine growth retardation. Many studies have shown that vascular endothelial growth factor A (VEGF-A) is a potent angiogenic factor, that is, it is responsible for the formation of new blood vessels from existing vessels. VEGF-A has been shown to be …
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Vascular Endothelial Growth Factor in the Aqueous Humor of Dogs With and Without Intraocular Disease
Vascular endothelial growth factor A (VEGF) is a potent mediator of blood vessel formation throughout the body. Intraocular diseases characterized by inflammation, hypoxia or neoplasia induce new blood vessel formation within the eye. The end result of such blood vessel formation may be blinding …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… sensing pathways including the Hypoxia Inducible Factor (HIF)-Vascular Endothelial Growth Factor-A (VEGF-A) and HIF-Erythropoietin (EPO) pathways. RNA sequencing (RNA-Seq) data from our previously published experiments revealed a potentially novel VEGF-A splice variant with excision of the VEGF …
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A Kinetic Study of Anti-VEGF-A Polyclonal Antibodies and Anti-VEGF-A ssDNA Aptamers
… anti-VEGF-A ssDNA aptamer were evaluated against vascular endothelial growth factor A (VEGF-A) using Surface Plasmon Resonance (SPR). It was hypothesized that the anti-VEGF-A aptamer had the same, if not better, binding kinetics than the anti-VEGF-A polyclonal antibody, and as such offers an ideal …
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The dissection of VEGFA stimulus-responsive regulatory and transcriptional changes in angiogenesis
… a time-course stimulation of human umbilical vascular endothelial cells (HUVECs) with vascular endothelial growth factor A (VEGFA) as a model system. Using data collected from multiple genome-wide assays I modeled the dynamic changes in epigenetic, transcriptional, and transcription factor …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
Angiogenesis, a hallmark of cancer, is induced by vascular endothelial growth factor-A (VEGF). As a result, anti-VEGF therapy is commonly employed for cancer treatment. However, anti-VEGF therapy generally provides modest efficacy in cancer patients and therapy-induced hypoxia results in a less …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
… study the radiation dose response of lymphatic endothelial cells. Putative lymphatic endothelial cell mitogens and antiproliferative agents, including vascular endothelial growth factor-A (VEGF-A), VEGF-C and AZD2171, a tyrosine kinase inhibitor of the VEGF receptors, were tested as radiation …
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The role of vascular endothelial growth factor isoforms in early follicle development
Since vascularization of the theca layer increases as follicles progress in size through preantral and antral stages, the principal angiogenic factor, vascular endothelial growth factor A (VEGFA), may influence follicle growth via regulation of angiogenesis. However, VEGFA may also influence …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… and promoted the expression of pro-angiogenic factors including leptin and vascular endothelial growth factor-A (VEGF-A). To investigate the potential involvement of anti-angiogenic factors in mediating the capillary remodelling response in obesity, I investigated the role of forkhead box O …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… is a key regulator of local blood distribution, vascular resistance and overall blood pressure (BP). Arterioles and capillaries are two important components of the microcirculation, which can undergo remodeling such as arteriogenesis, angiogenesis, or capillary rarefaction. Vascular remodeling …
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… Angiogenesis, or expansion of the existing vascular network, is required for the growth of solid tumors. For this reason, tumor angiogenesis is an attractive target for tumor therapy. Many of the current anti-angiogenic therapies target vascular endothelial growth factor-A (VEGF). VEGF binds …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… lagging their counterparts in the epithelial, endothelial, and immune lineages. Leveraging single-cell RNA-seq, three-dimensional imaging, and lineage tracing, first, we delineated different lung mesenchymal cell types and classified them into three-proximal-distal axes in the neonatal and …
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Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration
… transport and deliver cardiac regenerative factors to the ischaemic heart. Leveraging these unique features, this project explores the production of ‘supercharged’ platelets loaded with the regenerative factors thymosin β4 (TB4), fibroblast growth factor 2 (FGF2) and vascular endothelial …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… eosinophils, we identified the transcription factors activating transcription factor 3 (ATF3), and JUN proto-oncogene (JUN), as key regulators of the adipose eosinophil gene program. Using an immortalised human eosinophil cell line (EoL-1 cells), we found that ATF3 is involved in suppressing …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… data, we hypothesized that the developing cardiovascular system was the primary target organ for G-1-induced toxicity. Using quantitative in vivo imaging assays and transgenic zebrafish (fli1:egfp), we then demonstrated that G-1 exposure resulted in impaired cardiac morphology and performance as …
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Vascular Endothelial Growth Factor In Cortical Development
… each other and intimately linked.</p> <p>Many growth factors and transcription factors have roles in both angiogenesis and neurogenesis. Members of both the Notch and Inhibitor of DNA binding (Id) family of proteins have been shown to guide differentiation in neural stem cells, as well as to …
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Transcription Factor Engineering: Tools and Applications
Transcription factors play a vital role in the biology of every organism. By controlling gene expression they regulate growth, development, metabolism, reproduction, signaling, and response to the environment. They have also provided the basis for many useful tools in molecular biology. The …
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Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model
… have all failed, attributing to various factors such as a need for optimized dosage, developmental time for intervention, better metrics for human studies, and most prominently complexity of the mGluR pathway (Scharf et al., 2015). With this ubiquitous failure of mGluR inhibitors, new …
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Evaluation of suboptimal health status and prospective levels of oxidative stress biomarkers and angiogenic growth mediators with placental anatomy and pathology in normotensive and preeclamptic births
… oxidative stress (OS) biomarkers and angiogenic growth mediators (AGMs) with placental anatomy and pathology in normotensive and preeclamptic births in a Ghanaian Population. This longitudinal nested case-control study was based on the Ghanaian Suboptimal Health Status Cohort Study (GHOACS) that …
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Hypoxiemarker im equinen Endometrium im klinisch-pathomorphologischen Kontext
… der Antikörper gegen hypo-xia-inducible factor 1α (HIF-1α), Glucosetransporter 1 (GLUT1), vascular endothelial growth factor A (VEGF A) und vascular endothelial growth factor receptor 2 (VEGF-R2) hinsichtlich der Expression dieser Hypoxiemarker immunhistologisch untersucht. Für …
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