Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Vancomycin-resistant enterococci (VRE)"”.
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Assessing the Presence of Antibiotic-Resistant Enterococcus in Reclaimed Water Used for Spray Irrigation
… the Mid-Atlantic and Midwest regions of the US. Enterococci were isolated using membrane filtration, confirmed using biochemical tests and PCR, and tested for antimicrobial susceptibility using the Sensititre® dilution system. We detected total enterococci and vancomycin-resistant enterococci …
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Optimal Control Applied to a Mathematical Model for Vancomycin-Resistant Enterococci
Enterococci bacteria that cannot be treated effectively with the antibiotic vancomycin are termed Vancomycin-Resistant Enterococci (VRE). In this thesis, we develop a mathematical framework for determining optimal strategies for prevention and treatment of VRE in an Intensive Care Unit (ICU). A …
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Rectal culture screening for vancomycin-resistant enterococcus in chronic haemodialysis patients
Infection or colonisation with vancomycin-resistant enterococci (VRE) is common in chronic haemodialysis(HD) patients. However, there is limited information on the duration of VRE colonisation or on the reliability of consecutive negative rectal cultures to determine the clearance of VRE in chronic …
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Total Synthesis of Naturally Occurring Antimicrobial Peptides
… potent antimicrobial activity against highly resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and several species of Streptococci. Previous chemoenzymatic synthesis, semi-synthesis, and combinatorial …
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Gram-positive infections in patients with end-stage renal disease
… of infection. The effect on faecal carriage of vancomycin resistant enterococci (VRE) and Clostridium difficile toxins in patients treated with CAPD when empiric cephalosporin therapy was substituted for piperacillin/tazobactam was investigated. The introduction of piperacillin/tazobactam …
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Molecular Characteristics and Dissemination Mechanism of Vancomycin-Resistant Enterococci: A Tertiary vs. Non-Tertiary Health Care Hospitals
Vancomycin-resistant enterococci (VRE) have been endemic in Korea as a nosocomial pathogen. The aim of this study was to examine genetic relatedness and dissemination mechanism by comparative analysis of the antimicrobial and biomolecular characteristics of VRE isolates from tertiary and …
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Molecular Characterization of Vancomycin-resistant Enterococci from Clinical and Surveillance Specimens
BACKGROUND: Vancomycin-resistant enterococci(VRE) were first detected in Europe in 1986, and have been isolated from hospitalized patients worldwide. VanA resistance, characterized by high level resistance to vancomycin and teicoplanin, is the most prevalent in clinical enterococcal isolates. To …
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Mechanistic Insights Into Vancomycin Resistance In Clostridioides Difficile
… become more hypervirulent over the last decade. Vancomycin is currently a frontline antibiotic for the treatment of <em>C. difficile</em> infections. Yet, strains of <em>C. difficile</em> are becoming non-susceptible to vancomycin. Emergence of the vancomycin non-susceptible phenotype has led to …
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Functional and structural characterization of the mevalonate diphosphate decarboxylase and the isopentenyl diphosphate isomerase from Enterococcus faecalis
… blood stream and the endocardium), and multidrug-resistant strains have become a serious issue across countries. Vancomycin, a FDA-approved drug for the disruption of the bacterial cell wall biosynthesis, has been utilized to treat infectious diseases caused by Enterococci; however, the prevalence …
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Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… the prevalence and genomic profile of vanA vancomycin resistant enterococci (VRE) in Victorian health care facilities and compare this to patterns of patient movement between hospital networks. This study aimed to inform future studies on the transmission of vanA VRE and to provide valuable …
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Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… the prevalence and genomic profile of vanA vancomycin resistant enterococci (VRE) in Victorian health care facilities and compare this to patterns of patient movement between hospital networks. This study aimed to inform future studies on the transmission of vanA VRE and to provide valuable …
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ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… available antimicrobials. The emergence of drug-resistant bacterial species, namely methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), has limited the efficacy of several classes of antibiotics. Compounding this problem further is that many large …
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Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… to treat and cure. In recent years, methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the most threatening resistant strains. MRSA infections are now responsible for more deaths each year than AIDS in the United States.4 Due to the multidrug resistance of these "superbugs", …
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Identification and characterisation of lactic acid bacterial secondary metabolites with functional and health benefits
… bacteriocin with potent activity against vancomycin-resistant enterococci (VRE). It can be readily synthesized and has potential in the treatment of VRE infections. In silico analysis revealed that gallocin D is distinct from a previously identified S. gallolyticus bacteriocin, gallocin A, …
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The prevalence of toxin-antitoxin systems and their tractability as novel antimicrobial targets
… prevalence of TA systems in clinical isolates of vancomycin-resistant enterococci and methicillin-resistant S. aureus to validate TA systems as an antibacterial target. Two TA systems, Axe-Txe and RelBE, were found to be common among the pathogenic bacteria surveyed and were therefore further …