Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Vancomycin resistant Enterococcus"”.
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Rectal culture screening for vancomycin-resistant enterococcus in chronic haemodialysis patients
Infection or colonisation with vancomycin-resistant enterococci (VRE) is common in chronic haemodialysis(HD) patients. However, there is limited information on the duration of VRE colonisation or on the reliability of consecutive negative rectal cultures to determine the clearance of VRE in chronic …
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The effects of oligosaccharides and probiotic bacteria on the intestinal microflora and vancomycin-resistant enterococcus
… of probiotic bacteria on the suppression of vancomycin-resistant enterococcus in vitro.
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The relative importance of human and animal sources of vancomycin-resistant Enterococcus faecium in immunocompromised patients in hospital
Enterococcus faecium is a leading cause of hospital-acquired infection, disproportionally affecting immunocompromised and critically ill patients. Despite infection control measures, rates of vancomycin-resistant E. faecium (VREfm) bacteraemias have failed to decline in the United Kingdom, and …
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The Dynamics of Multi-Drug Resistant Organisms: Modeling Nosocomial Infection Control Measures
… exist to treat them, they are known to be highly resistant and have proven to be a reoccurring problem in hospitals, posing an increasing medical burden. Infection control measures have been implemented in order to reduce their impact and spread with various degrees of completeness and efficiency. …
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MULTIPLEX ASSAY DESIGN
… Enterobacteriaceae (CPE), vancomycin-resistant Enterococcus (VRE) and colistin resistance has been developed in this thesis. The resulting amplicons can be distinguished based on the principles of size, melting-state transitions, and sequence-specific probes. The problem of …
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Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections
… infections (HAI) caused by multi-drug resistant organisms (MDRO) are an important patient safety concern resulting in a substantial financial and clinical burden. This dissertation aims to contribute to the evidence base on institutional and patient level factors that predict multi-drug …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… In this study, a culture of Methicillin-resistant Staphylococcus aureus (MRSA) American Type Culture Collection (ATCC 43300) is grown to senescence for 48 hours in Muller Hinton (MH) broth. From senescence to the exponential phase, the levels of UDP-linked intermediates increase …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… Among the most concerning pathogens are vancomycin-resistant Enterococcus (VRE), which causes serious bloodstream, urinary tract, and wound infections, particularly in hospitalized patients. This thesis explores two complementary strategies to address this challenge: natural product …
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Patterns of antimicrobial resistance among enteric bacteria found in multi-site group-level cohorts of humans and swine
… in commensal Escherichia coli (EC) and vancomycin resistant Enterococcus faecium (EF) isolated from humans and swine in a semi-closed, integrated farrow-to-fork population were evaluated in a crosssectional study. Our objective was to establish baseline antimicrobial resistance patterns …
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Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
… target for many antibiotics to inhibit bacteria. Enterococcus species are gram-positive bacteria of the intestine in humans and animals that can lead to problematic infections of the gastrointestinal tract and the soft tissues. Vancomycin has been one of most important agents for the treatment of …
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Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
… hence making management of infections due to Enterococcus species difficult. Resistance to glycopeptide antibiotics, especially Vancomycin is of special concern as Vancomycin resistant genes are encoded on plasmids which can be transferred to other organisms. Currently, there is no documented …
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Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
… hence making management of infections due to Enterococcus species difficult. Resistance to glycopeptide antibiotics, especially Vancomycin is of special concern as Vancomycin resistant genes are encoded on plasmids which can be transferred to other organisms. Currently, there is no documented …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… so due to a precipitous rise in multi-drug resistant organisms. This rise in multi-drug resistant organisms poses a grave threat to the medical advances that have been made in the past century and underscores the need for new antibiotics. We have developed two promising candidates for …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… so due to a precipitous rise in multi-drug resistant organisms. This rise in multi-drug resistant organisms poses a grave threat to the medical advances that have been made in the past century and underscores the need for new antibiotics. We have developed two promising candidates for …
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Development of novel compounds to improve the resistance profile and spectrum of activity of fusidic acid
Recent reports indicate that antibiotic-resistant bacterial infections are rising and represent one of the most serious threats humans face today. Even more worrisome is the lack of treatment options to combat these pathogens as no new classes of antibiotics that target Gram-negative bacteria have …
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Investigating physiological and genetic characteristics of community acquired infections and potential antimicrobial interventions
Staphylococcus aureus and Enterococcus sp. infections occur in hospital and, increasingly, in community settings, with the potential of having different susceptibility to antimicrobial agents. The purpose of this study was to investigate the effect of antimicrobial agents against community acquired …
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Design and Discovery of Novel Bacteriocins
… The rise of AMR, that is, pathogens which are resistant to conventional antibiotic treatments, poses a significant threat to human health which, if not addressed, is predicted to contribute to the deaths of millions around the world annually by the year 2050. Novel therapeutics and a globally …
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Opportunities to measure and improve antimicrobial stewardship in the Irish hospital setting
… among gram negative organisms, and levels of vancomycin-resistant Enterococcus faecium (VRE) are of concern across Europe and in Ireland. Antimicrobial stewardship (AMS) programmes are well established in the Irish hospital setting but it is important that they continue to respond and evolve …
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Multi-target drug discovery against Staphylococcus aureus and Trypanosoma brucei infections
… in the context of the development of resistance-resistant antibiotics that involve multi-targeting. To extend the potential utility of this class of amidine compound, we tested them against Trypanosoma brucei, the causative agent of human African trypanosomiasis. The most active compound was a …
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The Lived Experience Of Inpatients On Contact Precautions
<p>This phenomenological study explores the lived experience of patients on contact precautions. While current literature reports mixed compliance rates among healthcare-workers, increased workload for staff, less time spent at the bedside, higher rates of adverse events, and higher rates of …
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