Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Valosin-Containing Protein"”.
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Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation.
Valosin containing protein (VCP)/p97 is a hexameric ATPase of the AAA family, which regulates a wide array of essential cellular processes. Dominant mutations in the N-domain of the VCP give rise to the complex disease syndrome known as Inclusion body myopathy with Paget disease of the bone and …
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Biomechanical and physiological investigations in the IBMPFD animal model
… multisystem disorder caused by mutations in the valosin-containing protein (VCP) gene. Knock-in mice expressing the common human p.R155H VCP mutation develop a progressive myopathy with ubiquitin-positive inclusion bodies, accumulation of abnormally shaped mitochondria in skeletal muscle and …
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Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
… of the Drosophila Golgi reassembly and stacking protein GRASP55/65 (dGRASP). Clu binds dGRASP and regulates accumulation of dGRASP at ER exit sites (ERES). Loss of Clu leads to increased ER stress and destabilized ERES protein Sec16, which, together with defects in αPS2 delivery, can be restored …
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Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… We have found that DGAT2 is a short-lived protein and is degraded via the ubiquitin- proteasome pathway. Our objective was to identify the lysine residues that are ubiquitinated and determine the role of ubiquitination in regulating DGAT2 stability and triacylglycerol synthesis. Initial …
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
… structural conservation across the AAA protein family makes designing selective chemical inhibitors challenging. Additionally, unlike chemical inhibitors that can stabilizea single conformational state of an enzyme, activator binding must be permissive to different conformational states …
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Biochemical and Structural Insights into VCP Unfoldase and WRN Helicase Complexes
<p>Valosin-containing protein (VCP or p97 in mammals, Cdc48 in yeast) is an essential member of the AAA (ATPases associated with diverse cellular activities) protein superfamily. As its family name suggests, VCP function is implicated in a broad range of biological pathways including protein …
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Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
… used to verify V5 insertion within the E1 glycoprotein. Replication kinetics experiments verified the virus replicated similarly to the parental VEEV TC-83 strain, while passaging experiments verified the tag was highly stable for up to 10 passages. This research produced a cost-effective and …
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Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
Multisystem Proteinopathy (MSP) is a disease that causes some combination of inclusion body myopathy with rimmed vacuoles, Paget’s disease of bone, and ALS/FTD. Several different genes give rise to the unique phenotypic expression of MSP. Given the variety of genes that cause MSP and the …