Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Valley of death"”.
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Alternative fuels : how can aviation cross the "Valley of Death"
… over 100 years. With the rapidly rising price of oil and concerns about supply, the military and the commercial airlines are fostering the development of an alternative aviation fuel industry. In the U.S., coal, oil shale and biomass offer great promise as alternatives to petroleum for the …
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Bridging the "Valley of Death" in stratified medicine : commercializing molecular diagnostics in oncology
Historically, the development of molecular companion diagnostics in oncology has underwhelmed the expectation of the medical field since the successful mapping of the human genome a decade ago. There have been several highly successful developments (Her2-neu, Genomic Health, etc.), but not the …
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From research to resource piloting near-Earth asteroids Through the Valley of Death
Can the resources of near-Earth asteroids be profitably mined? Near-Earth asteroids (NEAs) contain water, which can serve as a fuel in space, and platinum group metals, which are valuable on Earth. The presence of these resources has prompted high valuations of the near-Earth asteroid population, …
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Financing the "Valley of Death" : an evaluation of incentive schemes for global health businesses
… a new drug from preclinical development to a proof of concept clinical trial. This funding gap is sometimes referred to as the "valley of death", a reflection of the vast number of companies that are unable to raise the needed capital to progress into the clinic. The suggestion behind the "valley …
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The Influence of Financing Structure on Performance of MSMEs in South African: "The Valley of Death"
… as compared to large enterprises in terms of their financial decisions, ownership and management style, and behaviour. Therefore, this study will explore the gaps encountered by all MSMEs to grow their businesses. These include forms and type of industry, firm size, asset tangibility, and a …
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Investigating the Impact of Technology Progress on Bridging the Technological Valley of Death for Future Fusion Energy
… scientists continue research in pursuit of the ideal energy source, but that has not yet been achieved. Fusion energy has been believed an ideal energy source because it has various merits. Many developed countries have been researching fusion energy for a long time, but it has not yet …
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Crossing The Valley Of Death: A Multi-Sited, Multi-Level Ethnographic Study Of Growth Startups And Entrepreneurial Communities In Post-Industrial Detroit
<p>The intention of this research is to reveal the humanity of the startup experience for American growth companies. What is it about the growth entrepreneurship experience that has been hidden from view? Can we begin to articulate a holistic view of entrepreneurship--including those human …
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Exploring capabilities driving SME development of technological readiness within the marine sector
… fail to traverse the gap between the proof-of-concept and prototype demonstrated in the relevant environment (valley of death between TRL 3 to 7). This requires detailed real-time information on the challenges of SMEs through the chronological evolution path and required capabilities to …
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New financing and business models to accelerate the development of novel therapeutics
… with early drug development, leading to the "valley of death" in which promising drug candidates experience difficulties in reaching the market. These challenges have serious consequences for patient populations facing significant unmet medical needs. In this paper, we highlight three models …
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Drop-in replacement biofuels : meeting the challenge
… an introduction to drop-in replacement biofuels, the options amongst the technologies and feedstock available to produce them, their current economic performance and the evolution of their commercialization. In pursuing the latter a detailed examination of the funding path towards …
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Design, Fabrication, and Characterization of Metals Reinforced with Two-Dimensional (2D) Materials
The development of metals that can overcome the strength-ductility-weight trade-off has been an ongoing challenge in engineering for many decades. A promising option for making such materials are Metal matrix composites (MMCs). MMCs contain dispersions of reinforcement in the form of fibers, …
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The contribution of disease focused nonprofits to biomedical research and development
Patient-centered, disease-focused nonprofits are playing an increasingly prominent role in accelerating the development of new diagnostics, drugs, and therapies. They are engaging in a variety of complex venture philanthropic activities as they seek to bridge the "valley of death" gap between basic …
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Cost-effective allocation of public funding to promote the commercialization of renewable energy technology
… (RETs) is growing with the challenge of providing affordable electricity under increasing environmental and public health constraints while promoting energy security and improved energy access. Governments have chosen to intervene in the commercialization process to overcome market …
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Analytics for financing drug development
Financing drug development has a particular set of challenges including long development times, high chance of failure, significant market valuation uncertainty, and high costs of development. The earliest stages of translational research pose the greatest risks, which have been termed the "valley …
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Analysis and Comparison of the Creation of University Spin-off Startups in Deep Tech between the United States and Japan
… played a significant role in the economic growth of nations, particularly in the United States, where companies originating from these universities have generated substantial employment opportunities and revenue. There exists a substantial disparity in the number of spin-off companies created from …
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Developing a Framework for Conducting Health Technology Assessment in a Resource-Constrained Setting
… the medical device value chain (MDVC), often failing to bring context-appropriate innovations to market due to regulatory, evidence generation, and market access challenges known as the "valley of death". While early HTA (EHTA) and lifecycle HTA offer potential solutions, practical, …
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A Systemic View to Acquiring Innovation: How the US Air Force Selects and Integrates Private Sector Innovation
… a shift in global powers. In order to stay ahead of the new threat of near-peer advisories, the Chief of Staff of the Air Force established a plan, Accelerate Change or Lose. In this plan, General Charles Q. Brown asks USAF personnel to become innovative problem solvers. One way to bridge this gap …
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On creating cleantech confluences : best practices and partnerships to mobilize multiple sources of private capital into early-stage clean technologies
… is estimated that this will require investments of $40 trillion or $1.3 trillion per year in new and mature clean technologies. Currently, only about $0.3 trillion of investment goes to clean technology a year and the majority of that funding goes to mature, proven technologies. There is an …
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The Effect of Energy Policy on Cleantech Venture Capital and Private Equity Investment in Canada: Investors’ Perceptions of Risk and Opportunity.
… advanced fuels, and energy: storage, software, and efficiency (Gaddy et al., 2016), often have higher initial costs than traditional energy sources. As such, energy policies may be used to lower the associated costs with cleantech innovation, adoption, and diffusion. This has led …
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Análisis de la eficacia formativa en ingeniería biomédica para el desarrollo de propuestas de valor en Bogotá
… la eficacia de los programas de capacitación profesional en ingeniería biomédica en Bogotá para cultivar las habilidades requeridas que faciliten la mitigación de la discrepancia sistémica entre la investigación y el mercado, un fenómeno conocido como el "Valle de la Muerte" de la innovación. …