Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Vaginal mucosa"”.
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Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
… model that entails transplantation of human vaginal cysts into athymic nude mice has been implemented to study diseases of oral mucosa. To date, only one immunohistochemical study of this biocyst model has been reported. Nevertheless, conclusions made in that study were only based on the …
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Evaluation of immunomodulatory compounds for identification of an anti-herpetic innate immune response profile
… (STI) that commonly infects the genital mucosa and establishes a life-long latent infection. The virus periodically reactivates producing recurrent shedding episodes that increase the risk of acquiring other STI. There are no FDA-approved HSV-2 vaccines and treatment involves chronic …
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Exposure of 3D organotypic vaginal tissues to semen induces expression of the chemokine MCP-1, but does not alter tissue integrity
… that human semen induces inflammatory changes in vaginal epithelial cell cultures, which may promote HIV transmission. Since the normal human vagina is differentiated into multiple cell layers, we conducted a study to determine the effect of semen on EpiVaginal™, a 3-D organotypic differentiated …
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Interactive Effects of Bazedoxifene acetate and Conjugated Equine Estrogens on the Breast and Reproductive Tract of Postmenopausal Monkeys
… attenuating the maturation effects of CEE on the vaginal mucosa. As part of a nonhuman primate translational trial evaluating the global benefit to risk profile of BZA+CEE and BZA alone, we found that the addition of BZA to CEE significantly antagonized the stimulatory actions of CEE on breast and …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… 1 (HIV-1) transmission is infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has not been clearly elucidated. Although …
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A study of the influence of sperm surface proteins on the activity of avian spermatozoa In-vitro and In-vivo
… of spermatozoa to gain access to the uterovaginal insemination. This indicates a clear role for sperm surface-associated proteains and sperm surfarce sialic acid in vaginal sperm transport. <br/><br/>Sperm surface-associated proteins were also extracted by glycerol in a …
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HIV neutralization through use of antibodies and pharmacokinetics of topical applications
… tested to date have either elicited undesirable mucosal inflammation and epithelial lesions leading to increased seroconversions, or have been ineffective. One novel approach currently being explored is the use of monoclonal antibodies as components of topical microbicides. Monoclonal antibodies …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… shown to suppress the growth of Gardnerella vaginalis (G. vaginalis) in a porcine vaginal mucosa model. Recently, it was confirmed that metabolism of TFV by G. vaginalis reduced the extracellular level of ARV available to inhibit infection. We hypothesised that G. vaginalis not only …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… shown to suppress the growth of Gardnerella vaginalis (G. vaginalis) in a porcine vaginal mucosa model. Recently, it was confirmed that metabolism of TFV by G. vaginalis reduced the extracellular level of ARV available to inhibit infection. We hypothesised that G. vaginalis not only …
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Microbial interactions with epithelial surfaces.
… also been shown to inhibit the growth of several vaginal pathogens such as Gardnerella vaginalis, and Candida albicans, without inhibiting the grown of Lactobacillus crispatus, which is a predominant member of the vaginal normal flora. This finding suggests that GML may be useful as a treatment …