Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Vacuolating cytotoxin (VacA)"”.
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Characterization of the Helicobacter pylori vacuolating cytotoxin mediated induction of mitochondrial cell death mechanism
The Helicobacter pylori vacuolating cytotoxin (VacA) is a paradigm for microbial virulence factors that target and disable host cell mitochondria. VacA intoxication triggers mitochondrial dysfunction and metabolic stress, but the mechanisms underlying these perturbations in mitochondrial function …
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Molecular characterization of a sphingomyelin binding site in the vacuolating cytotoxin of H. pylori
… the primary receptor for the Helicobacter pylori vacuolating cytotoxin (VacA). While the cellular receptor has been identified, the molecular basis of SM recognition remains unknown. Molecular modeling of unrelated SM-binding proteins suggests that specific binding occurs through tryptophan rich …
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Helicobacter pylori VacA as a mitochondrial targeted pathogenic effector
… by pathogenic microbes is poorly understood. The vacuolating cytotoxin (VacA) of the human gastric pathogen Helicobacter pylori localizes to and disrupts mitochondrial function. In order to evaluate mitochondrial targeting of VacA, VacA associated cellular compartments were isolated by magnetic …
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Identification and Characterization of the Helicobacter Pylori Vacuolating Cytotoxin Receptor
… One of the most important virulence factors, the vacuolating cytotoxin (VacA), which is the only known exotoxin released by H. pylori into the stomach of infected individuals, contributes to the pathogenesis of infection by directly modulating several important properties of host cells. To be …
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Understanding the molecular mechanism on cell surface receptor interaction of helicobacter pylori vacuolation cytotoxin
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01
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An exploratory study of Helicobacter suis control strategies
… virulence factors in H. pylori, such as the cytotoxin-associated protein A (CagA) and the vacuolating cytotoxin (VacA), were not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria were present. Previous studies in …