Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Vaccinology"”.
-
Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… these vaccines. In this study, we used a reverse vaccinology approach to identify outer membrane and secreted Burkholderia proteins. These proteins were ranked according to predicted immunogenicity, and top vaccine candidates were selected based on the number and affinity of Major …
-
Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… these vaccines. In this study, we used a reverse vaccinology approach to identify outer membrane and secreted Burkholderia proteins. These proteins were ranked according to predicted immunogenicity, and top vaccine candidates were selected based on the number and affinity of Major …
-
Antibody-omics for biomarker discovery in vaccinology and infectious diseases
Antibodies play a critical role in the immune response by neutralizing toxins, thereby modulating vaccine response and disease outcome. Their protective effector functions are primarily regulated by the antigen-binding domain (Fab) and the crystallizable domain (Fc). While traditional methods of …
-
MOLECULAR DYNAMICS SIMULATIONS OF BIOLOGICAL MACROMOLECULES: APPLICATIONS TO STRUCTURAL VACCINOLOGY AND PEPTIDE DESIGN
This thesis work is splitted into two parts. The first one is about a computational method for epitope predictions on antigenic proteins, while the second one is related to the characterization of folding/unfolding processes of small natural polypeptides. Starting with the first topic, an …
-
Evidence-based vaccinology: supporting evidence-informed considerations to introduce routine hepatitis A immunization in South Africa
… informed by the principles of Evidence-Based Vaccinology for developing vaccine recommendations. The project included a mixed-methods approach: systematic reviews, a retrospective clinical folder review, mathematical modelling, and economic evaluation. A dynamic transmission model was built to …
-
Common Pool Goods and New Technology Adoption: How Canada Can Implement New Vaccinology Strategies Related to Johne’s Disease
With a growing population, there are risks to food security that would negatively affect a great proportion of the global population. Dairy is a particularly valuable dietary resource that feeds a large proportion of the global population. One key potential constraint on growth of milk production …
-
The rational structure-based design of a protein nanoparticle presenting a chimeric MenB antigen
… era of vaccine design and discovery, Structural Vaccinology, which seeks the rational structure-based design of improved vaccine antigens measured in terms of epitope presentation, stability and ease of production. In this project, a structural vaccinology approach is adopted toward the rational …
-
Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
<p>Despite remarkable progresses in vaccinology, therapeutic cancer vaccines have not achieved their full potential. We previously showed that the duration of antigen presentation critically affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe …
-
Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… antigens identified previously by a reverse vaccinology model. In these studies, we have established an optimal immunization procedure to test the efficacies of several protein-polysaccharide NPs when delivered alone or in a combination containing various proteins in a clinically relevant and …
-
Development of novel T cell assays and assessment of immune recognition to latency associated M.tuberculosis-specific antigens Rv2660 and Rv2659
… Our objective was to address 2 areas in TB vaccinology, firstly a novel postinfection TB vaccine strategy, and secondly, optimal measurement of vaccineinduced responses using a new immunological assay. The aim of the first study was to investigate human T cell responses to antigens that have …
-
Evaluation of Highly Conserved Burkholderia pseudomallei Proteins as pan-Burkholderia Vaccine Antigen Candidates
… vaccine. We have performed an in silico reverse vaccinology screen to scan the B. pseudomallei proteome for such highly conserved surface antigens and identified eight that matched our selection criteria. We recombinantly expressed three of these proteins (OmpA1, OmpA2, Pal) and attached them to …
-
Population Structure of Yellow Fever Virus: Influence of Viral Diversity on Vaccine Attenuation
… some of the landmark paradigm shifts in modern vaccinology. Recently, studies on the lifecycle of RNA viruses have indicated that population structure of these viruses is in many cases complex, which in itself may confer fitness within hosts or host ecologies. Thus, these dissertation studies …
-
Development and characterization of Shigella multiepitope fusion antigen (MEFA) for a broadly protective subunit vaccine against shigellosis with extended utility against enterotoxigenic Escherichia coli.
… and structure-based multiepitope-fusion-antigen vaccinology platform (MEFA), which incorporated the immune-dominant epitopes from the IpaD (invasion plasmid antigen D), IpaB (invasion plasmid antigen B), GuaB (IMP dehydrogenase), VirG (intracellular cell spreading protein) Stx1A (Shiga toxin 1 …
-
Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines
… delivery systems to advance a precision‑vaccinology framework targeting oxycodone and related opioids. A comprehensive analysis of preclinical and clinical literature demonstrated that adjuvant efficacy is drug‑specific. No single formulation suffices across nicotine, stimulant, and …
-
The characterisation of the cell surface of Staphylococcus aureus in the search for new therapeutic targets
… that could not be predicted using reverse vaccinology and other hypothesis-directed approaches commonly used to develop potential vaccine candidates. Ascertaining the repertoire of heparin-binding proteins was considered important as these proteins are bacterial virulence factors that …
-
Identification of protective rickettsial antigens for vaccine development
… Together, these findings validate a reverse vaccinology approach as a strategy to identify protective rickettsial antigens that induce cellular immunity. In addition, this work demonstrates the feasibility of developing a subunit vaccine that triggers T-cell-mediated cross-protection between …
-
Prediction and surveillance of antigenic variation in influenza and SARS-CoV-2 viruses
… therefore key areas of interest for influenza vaccinology. During my PhD, SARS-CoV-2 began exhibiting antigenic variation analogous to that seen in influenza, prompting the development of similar surveillance systems and prediction methods as historically applied to influenza. Traditionally, …
-
Immune responses against recombinant poxvirus vaccines that express full-length lyssavirus glycoprotein genes
… of current interest in the field of rabies vaccinology were addressed in this study. A primary concern regarding the disease is human mortalities, in the range of 60 000, reported every year. Most of these are linked to exposure to rabid dogs. In addition, a great number of post exposure …
-
Rabies serology: relationship between assay type, interpretation, and application of results
The immune status of an individual host or among a population is affected by important variables including the source and route of potential natural exposure and for vaccination consist of vaccine type, potency, and virus strain; vaccination route and schedule; and individual host factors. …
-
Data-driven strategies for vaccine design
… data to address two contemporary problems in vaccinology: 1. Developing an antibody vaccine against HIV, an example of a highly mutable pathogen; and 2. Understanding how the many immune components work collectively to effect a systemic immune response, such as to vaccines. In HIV-infected …
Page 1 of 2