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Showing 1 to 20 of 97 for “"Vaccinia"”.
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Vaccinia virus BTB-Kelch proteins
Vaccinia virus (VACV) is a valuable tool to study host-virus interactions and encodes a plethora of immunomodulatory proteins, among which three, A55, C2 and F3, have a BTB/BACK-Kelch (BBK) structure and are the focus of this study. Proteins containing BTB and Kelch domains function as adapters for …
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A role for myotubularins in vaccinia virus egress
Vaccinia virus (VACV) generates multiple distinct forms of infectious virus. Intracellular mature virus (IMV) particles are surrounded by a single lipid membrane and are mostly released upon lysis of the infected cell. Some IMVs are wrapped by an additional double membrane to form intracellular …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
Vaccinia virus (VV) is the prototypical member of the orthopoxvirus genus of the Poxviridae family, and is currently being evaluated as a vector for vaccine development and cancer cell-targeting therapy. Despite the importance of studying poxvirus effects on the human immune system, reports of the …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
Vaccinia virus (VACV) is a large, double-stranded DNA virus belonging to the Poxviridae family that was used as the live vaccine leading to the eradication of smallpox. Despite eradication through global vaccination, the precise immune mechanisms underlying recovery from infection are incompletely …
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Viral and cellular proteins involved in vaccinia virus egress
Vaccinia virus (VACV) is a large double-stranded DNA virus with a cytoplasmic site of replication. It has a complex life cycle that produces two distinct infectious virion forms, Intracellular Mature Virions (IMVs) and Extracellular Enveloped Virions (EEVs). The host cell microtubule trafficking …
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The elaborate interplay of natural killer cells and vaccinia virus
Vaccinia virus (VACV) is a poxvirus and is the vaccine used to eradicate smallpox. It is also an expression vector for heterologous antigens and an oncolytic virus for cancer therapy. VACV encodes multiple proteins that aid evasion of the host immune response. There is, however, an incomplete …
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Investigations into the vaccinia virus immunomodulatory proteins C4 and C16
Vaccinia virus (VACV) is the most intensively studied orthopoxvirus and acts as an excellent model to investigate host-pathogen interactions. VACV encodes about 200 proteins, many of which modulate the immune response. This study focusses on two of these: C16 and C4, that share 43.7 % amino acid …
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Applicability of vaccinia virus as cloning and expression vector for bacterial genes: mice immune responses to vaccinia virus expressing Brucella abortus and Listeria monocytogenes antigens
Previous studies by our group showed that vaccinia virus recombinants expressing Brucella abortus (BA) antigens heat shock protein GroEL, 18 kDa protein and Cu/Zn SOD, were unable to induce protective immune responses against Brucella challenge. This dissertation analyzes the possible reasons for …
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Characterization of Vaccinia Virus-Induced Cytotoxic Cells in the Syrian Hamster
… of a T-cell marker, Thy 1.2, on noninduced and vaccinia virus-induced hamster cytotoxic cells was studied utilizing a murine monoclonal anti-mouse Thy 1.2 antiserum ((alpha)-Thy 1.2) which detects a Thy 1.2 homologue on hamster T cells. In the hamster, (alpha)-Thy 1.2 plus complement (C') killed …
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Presentation of Recombinant Proteins in Modified Vaccinia Virus Ankara Extracellular Enveloped Virions
Modified Vaccinia Virus Ankara is a highly attenuated vaccinia virus strain developed during the smallpox eradication campaign. Nowadays recombinant attenuated poxviruses gain importance as live carrier vaccines against different infectious diseases and in cancer therapy. The aim of this work was …
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Autoradiographs Relating Nucleic Acid Metabolism to the Appearance of Intracellular Vaccinia Virus
Made available in DSpace on 2014-12-05T21:45:35Z (GMT). No. of bitstreams: 1 6101664.pdf: 5961925 bytes, checksum: 4dce39cc8b91bef8c1767daf8368b5b9 (MD5) Previous issue date: 1961
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Vergleich von rekombinanten Vaccinia- und DNA-Vektoren zur Tumorimmuntherapie im C57BL/6-Mausmodell
… auf der Basis des Plasmid-Vektors pCI, modified vaccinia virus Ankara (MVA) und MVA-infizierten dendritischen Zellen entwickelt und durch Sequenzierung, Western blotting und durchflußzytometrische Analyse überprüft. Die in vivo Wirksamkeit der Vakzinen wurde in verschiedenen Tumormodellen in …
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The Vaccinia Virus A56/Vcp Complex: Mechanism of Formation and Implications for Virulence
Vaccinia replication is complex, as it involves both producing new infectious particles as well as a myriad of proteins dedicated to combating the host’s immune response. Although these proteins are often called “non-essential”, they are frequently needed for the virus to achieve maximum virulence …
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Vaccinia Virus-Mediated Glioma Gene Therapy Using p53, IL-2 and IL-12
… attenuated variant of the Lister strain of vaccinia virus (VV) which has been proven to be a safe and effective vaccine vector. Other advantages include a wide host range, a strong promoter system, a high cloning capacity for foreign genes, and a high level of foreign gene expression. The …
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Characterization of the anti-viral effects inhibited by the vaccinia virus K1 protein
Vaccinia virus (VV), a member of the poxvirus family of double-stranded DNA viruses, is well-known as a highly effective vaccine against variola virus, the causative agent of smallpox. Poxviruses encode many strategies to evade the host immune and anti-viral response. One such host anti-viral …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
… project, the cell death profile of oncolytic vaccinia virus (oVACV) is characterised in human tumour cell lines. It was observed that oVACV can cause lytic cell death of multiple human cancer cell lines but that the virus suppresses many pathways of programmed cell death prior to lysis. Cell …
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Expression, Regulation And Processing Of Late Functions Involved In The Assembly Of Vaccinia Virions
… cycle of the prototypic member of this family, vaccinia virus, has been studied using metabolic inhibitors and, more recently, conditional-lethal temperature-sensitive (ts) mutants. In this study, biochemical, electron microscopic, and genetic analysis utilizing these tools has lead to a greater …
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In vitro characterization of the antiviral activity of Secomet V against vaccinia virus infections
… in folklore medicine. It exerted its anti-vaccinia virus activity by neutralizing cell-free virus rather than interfering with the downstream events following adsorption.
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The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection
… for tumor immunotherapies and vaccinations. Vaccinia virus (VV) is the most studied member of the poxvirus family and is responsible for the successful elimination of smallpox worldwide. It is unique among well-studied viruses in that it replicates solely in the host cytoplasm and is able to …
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