Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Vaccine trials"”.
-
Assessment of Informed Consent Understanding: HIV Vaccine Trials in Port-Au-Prince, Haiti
Introducing the HIV vaccine trials to research naive populations, particularly those in resource-limited settings of less industrialized countries, may include many obstacles. The aim of the informed consent process is to inform potential participants; however, measuring the efficacy of this …
-
The incidence of tuberculosis in adolescents in the context of proposed TB vaccine trials
… health problem and the development of new TB vaccines is one strategy proposed to address this scourge. Adolescents are a potential target group for new TB vaccines. Limited data are available in the scientific literature on the epidemiology of TB in adolescents. This thesis aimed to add …
-
The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1
Of the many vaccine trials which have taken place, the most promising results have been obtained from the recent phase 3 clinical trial which tested the ability of a dual protein and Canarypox virus recombinant to protect humans against HIV-1 infections. Because poxviruses are being developed as …
-
An exploration of young women's perceptions and experiences of participating in HIV prevention vaccine clinical trials in Nyanga Township in the Western Cape, South Africa
… AIDS (2001) to accelerate the development of HIV vaccine aimed at curbing the disease. This study sought to explore young women’s experiences and perceptions about HIV prevention vaccine clinical trials so as to inform the design and implementation of vaccine trials in Africa. The study employed …
-
Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines
… function was assessed in sheep vaccine trials. Our vaccination studies revealed that animals vaccinated with recombinant FhStf-1, FhStf-2, FhStf-3 and FhKT1 and orally challenged with F. hepatica metacercariae had a statistically significant weight gain when compared to …
-
Modelling the impact of prevention strategies on cervical cancer incidence in South Africa
… against HPV infection using the bivalent vaccine, with high coverage. However, due to the long delay between HPV infection and progression to cancer, the impact that vaccination will have on cervical cancer incidence will be unobservable in the near future. This thesis sets out to quantify …
-
Developing improved challenge viruses for macaque models of HIV-1 infection
… as a model of HIV-1 infection for pre-clinical vaccine studies. Although SHIV infection of macaques serves as the gatekeeper of promising vaccine candidates, it is limited by the fact there are a very small number of SHIVs available, and they do not represent the large genetic diversity of …
-
Diphtheria, the public health response and the origins of the childhood immunisation programme in Ireland
In common with most countries, the childhood immunisation programme in Ireland was founded on a successful public health response to diphtheria. The success of the antidiphtheria public health intervention in Ireland has meant that no case of the disease has been recorded in the state for almost …