Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Vaccine efficacy"”.
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Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… year. The World Health Organization recommends a vaccine as the best option to prevent this disease. The current vaccine, BCG, has a variable efficacy and does not protect adults. It is known that BCG vaccine becomes sequestered in special phagosome compartments of macrophages that do not fuse …
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Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants
… vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available adjuvants which can be sufficiently potent with minimal adverse side effects. The main goal of this thesis was to develop …
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Experimental technique for optimizing aerosolized vaccine efficacy by Erika J. Sandford.
… a realistic alternative to traditional injection vaccines for the developing world, where cold chain systems are impractical and the use of hypodermic needles can be unsafe. However, more research is needed to determine optimal parameters for vaccine aerosolization. This thesis presents an …
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Protective effects of acute moderate exercise on vaccination induced inflammation, arterial function and vaccine efficacy
Made available in DSpace on 2012-05-22T00:36:38Z (GMT). No. of bitstreams: 3 Ranadive_Sushant.pdf: 457084 bytes, checksum: 492031146bbbc7fbe5527de64c0b880a (MD5) Ranadive_Sushant.docx: 555781 bytes, checksum: 7d302932b58206790542decb2cfb23bd (MD5) license.txt: 4065 bytes, checksum: …
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Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens
… in Nicotiana benthamiana plants as potential vaccines against IBV. Modifying the full-length IBV Spike (S) protein resulted in high levels of VLPs resembling native IBV particles visualised under transmission electron microscopy. The highest VLP expression levels were obtained when the native …
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Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
… burden to world health and economy. Low efficacy of current inactivated influenza vaccines in the elderly and immunocompromized and the inability to protect against antigenically drifted or shifted strains of influenza virus are the two major problems in influenza vaccine research. To …
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Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
… virus during sexual contact, thus a prophylactic vaccine is needed. Therefore, the research presented here examines a factor that could be important in enhancing susceptibility to genital herpes disease as well as one that could be important in enhancing vaccine-afforded protection against it. …
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Antibody-omics for biomarker discovery in vaccinology and infectious diseases
… by neutralizing toxins, thereby modulating vaccine response and disease outcome. Their protective effector functions are primarily regulated by the antigen-binding domain (Fab) and the crystallizable domain (Fc). While traditional methods of antibody profiling have successfully applied …
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Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis
… are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in …
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Visualisation and analysis of patterns in serological data using "antibody landscapes"
… cohorts, one receiving an antigenically advanced vaccine strain and one a more typical vaccine strain choice, revealed many of the same patterns of response as seen with infection. Antigenically advanced vaccination generated greater responses against later strains but surprisingly, due to …
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Optimisation of a flow cytometry antibody panel to detect BCG-induced innate responses in infants
… mycobacterial disease susceptibility and/or BCG vaccine efficacy. Given the complexity of the interplay between the variability in disease susceptibility, BCG vaccine efficacy and human exposure to genetically diverse pathogens there is a need to study both host and pathogen genetic factors that …
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Understanding the importance of vaccine formulation in generating protective immune responses against Leishmania amazonensis challenge
… their infections suggests that development of a vaccine in feasible, although there is not one yet approved for human use. The immune responses in murine models are well characterized, and suggest possible correlates of protection induced by vaccination. However, these immune responses were …
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Development of a novel co-vaccination approach for pneumococcal and influenza infections
… to generate whole cell bacterial and viral vaccines with minimal impact on pathogen structure and antigenic determinants. This study presents the first evidence illustrating the use of this inactivation technique for development of a mucosal S. pneumoniae whole cell vaccine (γ- PN). …
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Creating a New Malaria Vaccine Design that uses a Blood Stage P. falciparum Chassis for Non-Blood Stage Antigen Presentation
… results in increasing drug resistance and poor vaccine efficacy. Current vaccine designs focus on a single stage in the parasite life cycle and antibody responses are inefficient in offering protection, leading to “malaria rebound” as a lack of immune response to multiple stages of the life …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
… trans-genes opens doors for their application in vaccine efficacy evaluation, disease diagnosis, pathogenesis studies, and treatment of diverse afflictions.
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
… trans-genes opens doors for their application in vaccine efficacy evaluation, disease diagnosis, pathogenesis studies, and treatment of diverse afflictions.
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Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines
Vaccines which use the strategy of fusing adjuvant murine â-defensin2 (mBD2) to an antigen in order to elicit stronger anti-antigen immune responses are referred to as murine â-defensin2 (mBD2) vaccines. Previous studies have validated the potential of mBD2 vaccines, thus in this study we focus on …
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Utilization of Cholera Toxin B as an Adjuvant for the Subunit PspA Vaccine, Provides Effective Protection against Streptococcus pneumoniae Challenge
… serotypes and a potential candidate as a subunit vaccine against <em>Streptococcus pneumoniae. </em>To increase the immunogenicity of PspA for long term and effective protection, this study utilizes Cholera Toxin B (CTB) as an adjuvant to effectively increase vaccine efficacy. We assessed the …
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MEMORY TH17 CELLS IN THE LUNG DURING SECONDARY BACTERIAL PNEUMONIA FOLLOWING INFLUENZA A VIRUS INFECTION
… pneumonia in IAV infected individuals. Current vaccines used to protect against bacterial infection are very limited because the antibodies generated are specific to the bacterial strain used in immunization. T-helper type 17 (Th17) cells are increasingly recognized as the key mediators of …
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Scaling in the immune system
… also be extended to understand how drug and vaccine efficacy differ in humans from model organisms like mice where most immunological experiments are conducted.
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