Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Vaccine antigen"”.
-
B CELL EPITOPE MAPPING OF RIVAX, A CANDIDATE RICIN VACCINE ANTIGEN
… arrest and apoptosis. One of the leading subunit vaccine candidates for ricin is RiVax, a two point mutant (V76M, Y80A) of RTA. RiVax has proven to be safe in humans, however, it could not elicit a robust toxin-neutralizing antibody response. In order to redesign a potent ricin subunit vaccine …
-
Evaluation of Highly Conserved Burkholderia pseudomallei Proteins as pan-Burkholderia Vaccine Antigen Candidates
… history of use as a biothreat agent. Numerous vaccine candidates to these B. pseudomallei complex species have been developed over the years, though none are currently approved for use in humans. On the other hand, the B. cepacia complex consists of >20 closely related species, many of which …
-
Model Membranes Study the Lipid-Reactivity of HIV-1 Antibodies and Vaccine Antigen
<p>One promising HIV-1 vaccine target is the membrane-proximal external region (MPER) of viral gp41. MPER is poorly immunogenic, however, the two rare neutralizing antibodies (NAbs), 2F5 and 4E10, bind to MPER with great neutralizing ability. Although their neutralizing mechanism represents a …
-
Formulation and characterisation of an effective particulate delivery vehicle for the novel sub-unit vaccine antigen, Ag85B-ESAT-6
… Ag85B-ESAT-6, a promising tuberculosis (TB) vaccine candidate. Initial work concentrated on formulating and characterising, both physico-chemically and immunologically, cationic liposomes based on the potent adjuvant dimethyl dioctadecyl ammonium (DDA). These studies demonstrated that …
-
Expression Of Hepatitis C Viral Non-structural 3 Antigen In Transgenic Chloroplasts
… people are infected globally (WHO). There is no vaccine available to prevent hepatitis C. The treatment with antiviral drugs is expensive, accompanied with various side effects and is limited only to those at risk of developing advanced liver disease. The treatment is also effective in only about …
-
Receptor Mediated Oral Delivery Of Bioencapsulated Green Fluorescent Protein Expressed In Transgenic Chloroplasts
… adequate amounts of the therapeutic protein or vaccine antigen. It is also an environmentally friendly approach due to effective gene containment and lack of transgene expression in pollen since the chloroplast genome is maternally inherited. To study receptor-mediated oral delivery of …
-
Identification of protective rickettsial antigens for vaccine development
… biodefense, there are no commercially available vaccines. Resistance to rickettsial infections and cross-protective immunity between typhus and spotted fever group rickettsiae are attributed to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens …
-
Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… Adenoviruses (Ad) are potential vaccine vectors for several pathogens. The proinflammatory response to Ad contributes to the response to vaccine antigens. We found that reactive oxygen species (ROS) are an important signal in the proinflammatory response to Ad. We identified that …
-
Structural analysis of capsular polysaccharides produced by some emerging Klebsiella pneumoniae serotypes
… produces a capsular polysaccharide (CPS or Kantigen), which constitutes an important virulence factor and a potential vaccine antigen. To date, there are up to 77 known distinct K. pneumoniae K-antigen serotypes, that have been classified through serotyping. Furthermore, there are additional …
-
Interplay between Extra-Germinal Center expansion of memory B cells and affinity maturation during the humoral recall response
According to the WHO, vaccines have saved more lives than any other medical intervention in history. Current estimates suggest vaccines save millions of lives annually. The importance of vaccines was recently highlighted by effective vaccines that curtailed the SARS-CoV-2 pandemic. Vaccines prime …
-
Expression Of Gal/galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts To Develop A Vaccine For Amebiasis
… and non-human primates. Therefore, anti-amebic vaccine could completely eradicate the disease. Entamoeba histolytica invades tissue and causes the disease in series of events. The disease is caused when the cyst form of the parasite is ingested with contaminated food or water. After excysting in …
-
Immune response to and pathogenesis of porcine epidemic diarrhea virus
… in situ hybridization for viral RNA or antigen. Viremia observed in the challenged pigs starting on dpi 1 and then disappeared after 7 dpi. PEDV RNA was also detected in various tissues besides the small intestine as early as 1 dpi, which coincided with viremia, but was no longer …