Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Vaccine adjuvants"”.
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Modulation of Allergic Disease through the use of Th1-associated Vaccine Adjuvants
… The purpose of this work was to identify a vaccine adjuvant that induced potent antigen-specific Th1 immune responses and determine its ability to reduce the development and severity of Th2- mediated allergic disease, using models of peanut hypersensitivity.</p><p>Three studies were …
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Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
… TLR7/8 agonists hold promise as potential vaccine adjuvants, since they directly activate antigen-presenting cells and enhance T helper 1-driven immune responses. A general introduction to TLRs, with an emphasis on the role of TLR7/8 activation in innate and adaptive immune responses is …
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SYNTHESIS AND STRUCTURAL DESIGN OF CARBOHYDRATE-BASED ARCHITECTURES: FROM VACCINE ADJUVANTS TO GLYCAN FOLDAMERS
… and synthesis of glycomimetics structures3, vaccine adjuvants4. Polyglycan structures have been used both for biology and for material chemistry purpose5. The first chapter of this PhD thesis focus the attention on vaccine adjuvant semi-synthesis. Vaccines are one of the oldest treatments in …
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
Cancer vaccines have evolved as a new treatment modality to eradicate cancer and has gained in popularity since the approval of Provenge® vaccine. By activating antigen-presenting cells (APCs), which, in turn, activate innate or adaptive immune responses, immunoadjuvants have become promising tools …
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Equine innate and adaptive immunity to viral infections
… immunity (CMI) to an inactivated West Nile virus vaccine in healthy yearling and adult horses. We also studied the potential of enhancing equine adaptive immunity to viruses and other pathogens by activation of innate immunity though TLR9 signaling pathway. We found vaccination with inactivated …
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EVALUATION OF ALPHA-D-GLUCAN NANOPARTICLE AS A VACCINE ADJUVANT
The use of nanoparticles for delivery of vaccine antigens and as vaccine adjuvants is appealing because their size allows efficient uptake by dendritic cells and their biological properties can be tailored to the desired function. Here, we evaluated the potential of dendrimer-like α-D-glucan …
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SYSTEMS BIOLOGY APPROACHES TO DECIPHERING COMPLEX IMMUNE RESPONSES
… of individual responses to 86 cytokines and 5 vaccine adjuvants in over 20 cell populations, representing one of the most comprehensive analyses of cellular responses to immune stimuli to date. Based on the dictionary, we created companion software for assessing cytokine activities, …
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Equine interferon-gamma and associated cytokines
… use of the cloned equine cytokine genes as vaccine adjuvants was evaluated by DNA co-administration with plasmids encoding the equine influenza virus antigens haemagglutinin and nucleoprotein, followed by viral challenge.
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Incorporation of CpG Oligodeoxynucleotides into α2-Macroglobulin: Development of a Novel Vaccine Adjuvant Delivery Mechanism
… are being clinically evaluated as treatments and vaccine adjuvants for infectious diseases, cancer, and allergic disorders. α2-Macroglobulin (α2M) is a human plasma protein that binds and modulates the activity of a variety of cytokines, growth factors, enzymes, and antigens. Upon proteolytic …
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… the development of immunomodulatory treatments, vaccine adjuvants, and breeding/management strategies to improve poultry health.</p>
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Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants
Adjuvants are immunomodulators and/or formulations/delivery vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available adjuvants which can be sufficiently potent with minimal adverse side …
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A study of the biological activity of bee venom and its fractions with regard to cosmetic science and immunology
… use in skin anti-ageing applications and as a vaccine adjuvant, respectively. BV fractions were obtained by reversed phase preparative chromatography and characterised by LC-MS and NMR techniques. The fractions were assayed for antimicrobial and cytotoxic activities against a range of microbes …
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Development of a Novel Vaccine Adjuvant and Delivery System for Cancer and Influenza
<p>Vaccines often require addition of adjuvants to boost the potency and longevity of antigen specific immune responses. At present, there is a scarcity of safe vaccine adjuvants and delivery systems that can stimulate both cellular (Th1) and humoral (Th2) immune response. Such adjuvants are …
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A study of the metabolic immune responses produced by some natural products
… and eicosanoids, were considered to act as vaccine adjuvants and to enhance the LPS-stimulated release of cytokines and inflammatory metabolite signalling, while others, such as propolis and gypenoside (Gyp), were suggested to antagonise LPS action, thereby modulating immune responses. …
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The Safety and Immunostimulatory Properties of Amorphous Silica Nanoparticles <10 nm in Diameter
… coatings for medical contrast agents and as vaccine adjuvants. Numerous studies have already been conducted to evaluate the cellular toxicity of these silica particles but still little is known about their effects both in vitro and in vivo, especially of nanosilica particles under 10 nm in …