Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"Vaccine Development"”.
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Malaria immunology and vaccine development
… latest attempts to produce an effective malaria vaccine. It goes on<br/>to describe the rationale behind the vaccines developed by the University of<br/>Oxford and others. A brief introduction to the process of planning and carrying out<br/>clinical trials of vaccines is then provided, and is …
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Approaches towards vaccine development against Neospora caninum
… A commercially available, inactivated vaccine induces the undesirable Th2 type of immunity against N. caninum. Therefore, two approaches towards vaccine development against N. caninum that were designed to induce potent cell mediated immunity have been explored in this dissertation. The …
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Identification of protective rickettsial antigens for vaccine development
… biodefense, there are no commercially available vaccines. Resistance to rickettsial infections and cross-protective immunity between typhus and spotted fever group rickettsiae are attributed to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… Adenoviruses (Ad) are potential vaccine vectors for several pathogens. The proinflammatory response to Ad contributes to the response to vaccine antigens. We found that reactive oxygen species (ROS) are an important signal in the proinflammatory response to Ad. We identified that …
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Beak and feather disease virus candidate vaccine development
… psittacine species. There is currently no vaccine against BFDV and safe and affordable vaccine candidates are needed to alleviate the disease burden caused by this virus. Production of the BFDV's major antigenic determinant, the capsid protein (CP), in the inexpensive and highly scalable …
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Pertussis: Advances in Vaccine Development and Disease Control Strategies
… programs. This thesis explores advancements in vaccine development and disease control strategies. It emphasizes virulence factors such as Vag8, SphB1, BrkA, and BapC as potential components for acellular vaccines. Additionally, it discusses current trends in pertussis research and development, …
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Gene expression profiling approach towards enhancement of malaria vaccine development
… with significant economic consequences. The development of vaccines that provide sterile protection against pathogenic infection by the Plasmodium parasites that cause malaria is thus a major global public health priority. This dissertation describes three gene expression profiling …
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Phylogenetics and New Approaches to Vaccine Development for West Nile
… vesicular stomatitis virus (rVSV) based vaccines cleverly incorporate reverse genetics to recover a recombinant virus expressing a foreign antigen of interest. rVSV vectored vaccines expressing the LSU-AR01 envelope (E) glycoprotein were engineered and administered to mice in a …
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Molecular modeling of bacterial polysaccharide antigens to inform future vaccine development
Polysaccharide conjugate vaccines have been pivotal in reducing the prevalence and severity of bacterial infectious diseases worldwide, preventing countless deaths. The effectiveness of a vaccine can be extended if the selected vaccine strains in a multivalent vaccine cross-protect against …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
… of outbreaks. Unfortunately, inactivated vaccines that are safe for both young and pregnant animals require boosters, and live-attenuated vaccines are not considered safe in pregnant animals. Thus, the development of a live-attenuated vaccine that is safe in pregnant animals is invaluable …
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Vaccine Development Strategies for Crimean-Congo Hemorrhagic Fever Virus and its Tick Vector
… signs of disease from infection with CCHFV, vaccine development has focused on preventing human disease. Despite extensive research, no vaccine candidates have advanced to clinical trials. This dissertation aimed to utilize different vaccine platform technologies to target unique points in …
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
… factors that may be suitable for future vaccine development.
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Investigating Genetically Engineered Virus-Like Particles Using Molecular Dynamics Simulations for Enhanced Vaccine Development
… them safe and highly immunogenic platforms for vaccine development. Genetic modifications can expand the use of VLPs, such as the insertion of antigens to target various diseases. However, designing stable VLP-based vaccines through genetic engineering is challenging and unpredictable due to the …
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Severe Acute Respiratory Syndrome Coronavirus-2 Vaccine Development: A Virus-Like Particle Vaccine Approach
… protein sequence. In this project, we produced a vaccine against SARS-CoV-2 that was composed of three SARS-CoV-2 Spike protein epitopes inserted into the ∆HBcAg VLP. These insertions included Spike epitopes predicted to induce a humoral and/or cell-mediated immune response. The immunogenicity of …
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How Pharmaceutical Companies Utilize Platform Strategy: A Study of the COVID-19 mRNA Vaccine Development
… and BioNTech were able to develop the COVID-19 vaccine so rapidly and provides new insights into platform theory. The COVID-19 pandemic, which began in China in late 2019, spread globally within a month, causing immense damage. Vaccines were the most critical technology needed to fight the …
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Vaccine Development Against Porcine Epidemic Diarrhea Virus Utilizing the Hepatitis B Virus Core Antigen Protein
… There has recently been renewed interest in a vaccine that is made from a different source, which might help eliminate some of the side effects of those that currently exist on the market. This project outlines three experiments performed in animals. During the first experiment, a structural …
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The construction and characterization of recombinant sindbis virus vectors as a platform for anthrax vaccine development
… to protect against B. anthracis. Anthrax Vaccine Adsorbed (AVA) is the only licensed vaccine preparation currently used however, immunogenicity is variable and the boosting regimen is long-term and must be maintained to ensure continued protection. Protective antigen (PA), the chief …
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The Plasmodium 6--cysteine protein family in sexual and sporozoite stages: targets for malaria vaccine development
Contains fulltext : 93617.pdf (Publisher’s version ) (Open Access)
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Characterization of virus strain- and pig age-dependence of porcine epidemic diarrhea virus: Implications for vaccine development
… S INDEL PEDVs. While two commercially available vaccines (one killed PEDV vaccine and one RNA particle PEDV vaccine) exist in the U.S., their efficacy is limited in naïve pigs. Therefore, a safe and efficacious PEDV vaccine is still needed to control the disease. Previous pathogenicity studies …
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