Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"Vaccination Strategies"”.
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Computational Study of Vaccination Strategies to Change B Cell Immunodominance
… thereby informing more effective vaccine design strategies. In this thesis, computational models are developed to investigate strategies for modulating B cell immunodominance in vaccinations. Experimental data from collaboration are used to validate model findings. The first project investigates …
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School based versus supplemental vaccination strategies in the delivery of vaccines to 5-19 year olds in Africa - a systematic review
… immunisation activities (SIAs) and school based vaccination (SBV) are two common strategies used to complement the EPI in vaccine delivery. Therefore, this review aimed to assess the effectiveness of SIAs compared to SBV in the administration of vaccines to 5-19 year olds in Africa. Methods and …
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Systems analysis of vaccination in the United States: Socio-behavioral dynamics, sentiment, effectiveness and efficiency
… examines the socio-behavioral determinants of vaccination and their impacts on public health, using a systems approach that emphasizes the interface between population health research, policy, and practice. First, we identify the facilitators and barriers of parental attitudes and beliefs …
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Epidemic Simulation and Mitigation via Evolutionary Computation
… to generate epidemic models, vaccines, and vaccination strategies to mitigate unfavourable outcomes. To this end, a generative representation to create personal contact networks, representing the social connections within a population, known as the Local THADS-N generative representation is …
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Personalized Decision Modeling for Intervention and Prevention of Cancers
… mortalities, personalizing the corresponding strategies and decisions so as to provide the most appropriate or optimal medical services for different patients can greatly improve the current cancer control practices. This dissertation research performs an in-depth exploration of personalized …
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Cost-Effectiveness Analysis Using Agent-Based Modelling: A General Framework with Case Studies
… context to quantify the economic impact of vaccination strategies for prevention of infectious diseases. We present two case studies for a human-to-human infection transmission (i.e., Haemophilus influenzae) and a vector-borne disease (i.e., Zika). In each case, we detail the construction of …
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Human Papillomavirus vaccination: Immunological and epidemiological studies
… and used it as a basis for modeling the optimal vaccination strategies in this population. By the year 2055, vaccination of females starting at age 12 in 2008 was most efficient, estimated to prevent 5.8 million cumulative HPV16 infections. Catch-up programs had a strong additional preventive …
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Predicting the Antigenic Evolution of Influenza Viruses with Application to Vaccination Strategy
… even in best case scenarios current influenza vaccination strategies cannot completely avoid antigenic mismatch. I then present the first study that quantifies the link between degree of antigenic mismatch and vaccine effectiveness. Knowledge of the molecular variation responsible for major …
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Dynamics of Naturally Acquired Antibody Against Haemophilus Influenzae Serotype 'A' and the Impact of Vaccination
… key questions must be addressed to ensure that vaccination is effective in curtailing and possibly eliminating Hia from affected populations. In this thesis, we develop mathematical models of Hia transmission and control dynamics and analyze them to address important practical questions. By …
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A statistical mechanics approach to vaccination against HIV
… models of AM could help identify promising vaccination strategies and shed light on a previously ignored problem in basic immunology; meaning how AM works with several antigens. For my thesis I investigated two pathways for breadth evolution. First, motivated by experimental findings that …
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Engineered microneedles for transcutaneous vaccine delivery
… These inherent limitations of needle-based vaccination on global health have led to a strong impetus to develop needle-free vaccination strategies which have the potential to improve vaccine efficacy and availability, enhance the ease, speed, and safety of vaccine administration, and reduce …
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
… might escape the immune protection conferred by vaccination strategies. It is also becoming clear now that efficient genomic surveillance would require monitoring the host gene expression to identify prognostic biomarkers of efficacy and disease progression. Here we applied an integrated workflow …
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… disease in some contexts. Thus we need better vaccination strategies to protect infants. Here, we establish mouse models of influenza virus- and flavivirus-specific maternal antibody transfer. We show that influenza virus-specific maternal antibodies protect infant mice from influenza disease …
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Mixed Strain Identification of Porcine Reproductive and Respiratory Syndrome Virus in Multiplexed Samples using Nanopore Sequencing
… individual animals and may be used to determine vaccination status. This new approach will help producers and veterinarians make better-informed decisions about co-mingling of animals and vaccination strategies, thus reducing the emergence of new, pathogenic strains of PRRSV.
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… or humoral immunity. Traditional needle-based vaccination strategies primarily induce humoral immunity and are inefficient at eliciting robust CTL responses using subunit or whole protein formulations. Viral adjuvant vectors capable of generating strong CTL responses face limitations of …
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Characterisation of the T cell responses induced by BCG in infants over the first year of life
… likely to remain central to future TB prevention strategies, which could include a BCG prime at birth, followed by boosts with novel TB vaccines within the first year of life, or at later ages. Therefore, a comprehensive understanding of BCG induced immunity is required for the successful design …
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SYSTEMS BIOLOGY APPROACHES TO DECIPHERING COMPLEX IMMUNE RESPONSES
… dysregulation of immune responses. Therapeutic strategies targeting the immune system have succeeded in treating a wide range of diseases. However, we lack the detailed understanding of the immune system needed to design more effective and targeted therapies for many immune-mediated diseases …
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Estimating network structure and propagation dynamics for an infectious disease : towards effective vaccine allocation
… Design of effective resource allocation strategies requires good understanding of the underlying contact network and of the propagation dynamics. In this thesis we develop a parameter estimation method that learns the network structure, among a family of graphs, and disease dynamics from …
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Molecular candidates for Blocking the Transmission of Vector-Borne diseases
… year as of 2017. So far, extremely few reliable vaccination strategies and solutions have emerged. Transmission blocking vaccines are one among many solutions available to manage the control of VBDs. These require identification of both vector and pathogen molecules that play important roles in …
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Evidence-based vaccinology: supporting evidence-informed considerations to introduce routine hepatitis A immunization in South Africa
… In high hepatitis A endemic settings, routine vaccination against HAV is not necessary due to high rates of “natural immunization”. Recent data suggest a possible shift from high to intermediate HAV endemicity may be occurring in South Africa. Countries with intermediate HAV endemicity and no …
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