Global ETD Search
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Showing 1 to 3 of 3 for “"VWF release"”.
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Development and validation of an in vitro human model of drug-induced vascular injury
… was recapitulated ex vivo von Willebrand factor (VWF) release, one of the hallmarks of DIVI, was analysed using four drugs reported in the literature to produce DIVI. The same four drugs were then tested in human EC and SMC for the following features of DIVI: (1) VWF release; (2) EC monolayer …
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Regulation of Weibel-Palade Body Exocytosis by alpha-Synuclein in Endothelial Cells
… showed that PMA-, thrombin- or forskolin-induced VWF release or translocation of P-selectin from Human Umbilical Vein Endothelial Cells (HUVECs) were inhibited by overexpression of a- and b-synuclein, but not g-synuclein. The overexpression of three point mutants (A30P, A53T and E46K) found in …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
Von Willebrand factor (VWF), a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF …