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Showing 1 to 20 of 53 for “"VSV"”.

  1. EXPRESSION AND PROCESSING OF HIV-1 GP160 WITH HOMOLOGOUS AND HETEROLOGOUS SIGNAL SEQUENCES USING A VSV VECTOR SYSTEM

    Wu, Kunyu2006

    … Vesicular Stomatitis Virus New Jersey serotype (VSVnj) vector system. I found that the HIV-1 gpl60 protein can be efficiently expressed and processed when the HIV-1 gpl60 gene was inserted between the G and L genes of VSVNJ. The processing of the gpl60 protein and the release of gpl20 was more …

    uwo Repository record

  2. The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models

    Qi, LeiThe University of Western Ontario2024

    … with the Vesicular Stomatitis Virus (VSV)-vectored HIV vaccine (VSVXN2∆G/CDO-EBOVGP+HIV-1 Codon-optimized A74_Env-EC/SIV_Env-TMCT) in Rhesus macaques provided protection to 50% of the animals against low-dose challenges with SHIVenv_SF162P infection, making it an effective vaccine …

    uwo Repository record

  3. Investigation of Vesicular Stomatitis Virus Interaction with Host Cell Proteins and Associated mRNA Structures

    Davidson, Adam SeanWake Forest University2016

    Vesicular Stomatitis Virus (VSV) is a member of the Rhabdoviridae family that serves as the prototype for highly pathogenic negative-sense non-segmented RNA viruses such as Ebola and rabies viruses and for segmented RNA viruses like influenza. VSV has also proven to be an effective vaccine vector …

    wfu Repository record

  4. RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE

    Cody, Brooke LeaWake Forest University2009

    … activity of vesicular stomatitis virus (VSV). In Chapter 1 I analyzed the timing of the different steps of the virus replication cycle in PC3 prostate cancer cells (VSV-resistant cells) to LNCaP prostate cancer cells (VSV-sensitive cells). My experiments revealed that several early steps …

    wfu Repository record

  5. ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE

    Cary, Zachary DylanWake Forest University2011

    Vesicular stomatitis virus (VSV) is a potential oncolytic virus for treating glioblastoma multiforme (GBM), an aggressive brain tumor. Matrix (M) protein mutants of VSV have shown greater selectivity for killing GBM cells versus normal brain cells, compared to VSV with wild-type M protein. The goal …

    wfu Repository record

  6. CHANGES IN SUSCEPTIBILITY TO VESICULAR STOMATITIS VIRUS DURING PROGRESSION OF PROSTATE CANCER

    Yu, NanmengWake Forest University2013

    Vesicular stomatitis virus (VSV) is an attractive oncolytic virus. Differing sensitivity to VSV oncolysis of human prostate cancer cell lines has been observed in previous experiments. The goal of my experiments was to determine the mechanisms of sensitivity and resistance to VSV.

    wfu Repository record

  7. Suppressive effect of a nucleic acid-hydrolyzing recombinant antibody (3D8) on viral multiplication

    정, 의정2011

    … of 3D8 scFv against vesicular stomatitis virus (VSV) that belongs to RNA viruses in HeLa cells. When the purified 3D8 scFv was directly imported into HeLa cells by an electroporation and the cells were infected with VSV (MOI=10), significant inhibition against VSV multiplication and VSV-induced …

    ajou Repository record

  8. Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer

    Cudmore, AlisonUniversité d'Ottawa / University of Ottawa2022

    … carboplatin, the current standard of care, and VSV∆M51, a promising OV candidate. After a study of genetically diverse models, constitutive KRas activation enhanced VSV∆M51 replication in-vitro and sensitivity in syngeneic in-vivo models. VSV∆M51 prolonged survival in syngeneic tumour- bearing …

    ottawa-retro Repository record

  9. MODIFICATION OF VESICULAR STOMATITIS VIRUS G PROTEIN FOR TARGETED GENE DELIVERY INTO PSCA-POSITIVE TUMOR CELLS

    Günes, SerapTechnische Universität Dresden

    … cell. The Vesicular Stomatitis Virus G protein (VSV-G) is a well-liked choice for pseudotyping the retroviral vectors since it confers on the viral particle stability to allow concentration to high titers necessary for the clinical applications. However, the main drawback of VSV-G, the …

    qucosa-diss

  10. Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus: A New Live Vectored Vaccine for Human Norovirus

    Ma, YuanmeiThe Ohio State University2013

    … gene (VP1) of a human NoV was inserted into the VSV genome at the glycoprotein (G) and large (L) polymerase gene junction. Recombinant VSV expressing VP1 protein (rVSV-VP1) was recovered from an infectious cDNA clone of VSV. Expression of the capsid protein by VSV resulted in the formation of …

    ohiolink Repository record

  11. Investigation of the Vesicular Stomatitis Virus Matrix Protein: Uncoating and Assembly

    Mire, Chad E.2016

    <p><em>Vesicular Stomatitis Virus</em> (VSV) is a simple, enveloped, nonsegmented negative-strand RNA virus and is the prototype rhabdovirus to study viral entry, transcription, replication, and assembly. The matrix protein (M) of VSV is a central component of the viral replication cycle. While …

    tenn-hsc Repository record

  12. Entwicklung alternativer Vakizinierungsstrategien gegen Masernvirusinfektionen im Tiermodell

    Schlereth, BerndUniversität Würzburg

    … ein rekombinantes vesikuläres Stomatitis Virus (VSV-H) verwendet, welches das MV-Hämagglutinin (Hauptantigen für MV-neutralisierende Antikörper) in der Hülle von VSV exprimierte. Eine alternative MV-Vakzine muß die beiden MV-Glykoproteine (Hämagglutinin- und Fusionsprotein) enthalten, da sie …

    wurz-thes Repository record

  13. Determining the Innate and Adaptive Immune Responses to Vesicular Stomatitis Virus Vaccine Vectors

    Smedberg, JasonWake Forest University2014

    Vesicular stomatitis virus (VSV) vaccine vectors have been engineered to express many different antigens. Studies in mice and nonhuman primates have demonstrated efficacy against several pathogens. A novel strategy to enhance VSV as an effective vaccine is to engineer vectors that induce innate …

    wfu Repository record

  14. Cellular Immunity in Mouse Models of Viral Encephalitis

    Steel, Christina Dawn2019

    … application of vesicular stomatitis virus (VSV) caused acute infection of the murine central nervous system (CNS) with associated morbidity and significant mortality in mice. However, VSV encephalitis was not invariably fatal, suggesting that the CNS contained a professional …

    odu Repository record

  15. Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells is Dependent on Microtubules and Actin Filaments

    Yacovone, ShalaneWake Forest University2015

    … genetic material. Vesicular stomatitis virus (VSV) is a prototype Rhabdovirus that has been used to study transport within the cell. We developed a new method of analysis of fluorescence within the cytoplasm called the border-to-border distribution method (BTBDM). The well characterized effect …

    wfu Repository record

  16. Formation of membrane domains induced by the G and M proteins of vesicular stomatitis virus

    Luan, PengUniversity of Illinois at Urbana-Champaign2011

    Vesicular stomatitis virus (VSV) buds from specialized regions or domains on the plasma membrane of infected cells. These domains are composed mainly of viral proteins and they are enriched in certain lipid species. The properties of the two envelope-associated proteins of VSV, the glycoprotein (G) …

    uiuc Repository record

  17. Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway

    Zhou, Zhicheng, Mr2016

    … more resistant to virus infection, including VSV and H1N1 influenza virus. Mechanistic studies showed that CARMA3 and BCL10 physically interacted with MAVS and directly regulated MAVS aggregation. Overexpression of CARMA3 and BCL10 inhibited MAVS aggregation. Consistently, MAVS aggregation …

    uthsc Repository record

  18. Exploring a Role for the Parkinson Disease-Linked GBA1 Gene in Host Responses to Infections

    Hake-Volling, QuintonUniversité d'Ottawa / University of Ottawa2021

    … two. In response to Vesicular Stomatitis Virus (VSV), p.D409V mice survived at a higher rate overall compared to their wild type littermates, while homozygous males survived at a higher rate compared to wild type males in a sex-dependent manner. Heterozygous females had a lower viral load in the …

    ottawa-retro Repository record

  19. Phylogenetics and New Approaches to Vaccine Development for West Nile

    Iyer, Arun VenkateshVeterinary Medical Sciences - Pathobiological Sciences2022

    … edge. Recombinant vesicular stomatitis virus (rVSV) based vaccines cleverly incorporate reverse genetics to recover a recombinant virus expressing a foreign antigen of interest. rVSV vectored vaccines expressing the LSU-AR01 envelope (E) glycoprotein were engineered and administered to mice in a …

    lsu-thes Repository record

  20. SEISMIC VELOCITY, RADIAL ANISOTROPY IN THE CRUST AND UPPER MANTLE OF NORTHEASTERN TIBETAN PLATEAU FROM SURFACE WAVE TOMOGRAPHY

    Li, Lun 1984-University of Houston2013

    … dissertation is to construct a 3-D SV velocity (VSV) model using Rayleigh wave data in the NE Tibetan Plateau. The average and 2-D variations of phase velocities were obtained at 14 periods from 20 to 100 s and then used to constrain 1-D and 3-D VSV models. The entire region is characterized by …

    houston Repository record

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