Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"VSMC"”.
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Investigating the Mechanisms Underlying the Heterogeneous VSMC Contribution to Vascular Disease
… blood vessels, vascular smooth muscle cells (VSMCs) exist in a contractile, quiescent state but upon vascular insult can switch phenotype to activate proliferation, migration and remodelling of the extracellular matrix. Phenotypically switched VSMCs contribute most cells within neointimal …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… how this influences vascular smooth muscle cell (VSMC) calcification. In the first study, experiments in primary murine Ddr1+/+ or Ddr1-/- VSMCs revealed that DDR1 promotes VSMC calcification in a stiffness-dependent manner by a positive feedback loop between DDR1 and actomyosin contractility. …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… accompany vascular smooth muscle cell (VSMC) phenotypic switching, a hallmark of vascular disease. Upon insult, VSMCs downregulate contractile proteins and upregulate genes linked to vascular remodelling, such as matrix metalloproteinases (MMPs) and pro-inflammatory cytokines. However, …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs …
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Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease
Deregulation of vascular smooth muscle cell (VSMC) phenotypic switching is implicated in vascular disease development and VSMCs produce the majority of cells in late-stage atherosclerotic plaques. However, VSMC accumulation in mouse models of vascular disease arises from clonal expansion of very …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
Introduction: Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and display phenotypic plasticity that influences both plaque growth and stability. The fibrous cap, a stabilising feature of plaques, contains an abundance of VSMC-derived cells. However, the cellular …
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Distinguishing the Role of the c-myb Proto-Oncogene in Mouse Models of Cardiovascular Disease
… c-myb regulates vascular smooth muscle cell (VSMC) differentiation from embryonic stem cells, as well as the proliferation of mature VSMCs. The literature points toward several areas of opportunity to examine the role of c-myb in cardiovascular biology: first, to examine the role of c-myb in …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… di cellule muscolari lisce vascolari (VSMC). Queste cellule, pur mantenendo un’attività metabolica, mostrano importanti alterazioni morfologiche, disfunzioni mitocondriali e adottano un fenotipo secretorio associato alla senescenza (SASP). Nonostante la crescente consapevolezza del …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying FOXO3a-mediated cell death in this …
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Isolation, characterization, and functional assessment of novel smooth muscle like stem progenitors
Vascular smooth muscle cells (VSMC) are one of the key players in the pathogenesis of cardiovascular diseases. The origin of neointimal VSMC has thus become a prime focus of research. VSMC originate from multiple progenitors cell types. In embryo the well-defined sources of VSMC include; neural …
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ROLE OF CKD AND CASPASE-1 IN NEOINTIMAL HYPERPLASIA DEVELOPMENT
… hyperplasia (NH). Vascular smooth muscle cells (VSMC) are critical for the development of NH lesions, as they have the ability to modulate their phenotype from a "contractile" to a "synthetic" phenotype in the presence of uremia, through the regulation of sensor genes for uremia danger signals …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
Vascular smooth muscle cells (VSMCs) possess a remarkable capacity to change phenotype in response to injury or inflammation. In healthy arteries, VSMCs exist in a contractile state, but upon vascular inflammation or injury, they can switch into an activated state, in which they downregulate the …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… into vascular smooth muscle cells (VSMC), analysed with a multi-omic approach, and the findings were validated in vitro. This work is the first to perform deep molecular phenotyping on LOX, MYLK and SMAD4 genetic variants in the context of aortic disease. TAD variant heterozygous …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… ETB receptors in vascular smooth muscle cells (VSMC) in subcutaneous resistance arteries. 2. The level of the up-regulation of contractile AT1 and ETB receptors depends on the degree of underlying IHD. The phenomenon is also correlated to the level of the systolic blood pressure. 3. Temporal …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
… switching of vascular smooth muscle cells (VSMCs) from a contractile /differentiated state to a synthetic/ proliferative state is a hallmark of many cardiovascular diseases, driven in part by extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in differentiated …
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The Role of Ca²⁺/CaM-Stimulated Phosphodiesterase 1C in Vascular Smooth Muscle cells of the Synthetic/Activated Phenotype
… with a change in vascular smooth muscle cell (VSMC) phenotype, resulting in a hyperproliferative cell devoid of contractile properties. This cell has been defined as “synthetic/activated” and differs from the normal “contractile/quiescent” VSMC in several aspects. Previous investigations have …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
… the vascular smooth muscle cells (VSMC) in the vessel wall become activated and start to migrate and proliferate. Extracellular matrix molecules are important for this process, but not much was known about VSMC laminin expression in health or disease. Therefore, this was studied in …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… transcripts in vascular smooth muscle cells (VSMC). FXR1 was identified as an HuR interacting protein by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The-HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 …
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… of GPR68 and its cyclic AMP signals on VSM cell (VSMC) growth in the context of CVD in not known. The hypothesis of this study was to determine that acidic activation of proton sensing GPR68 and its Gs signals regulates VSMC growth via decreased cell proliferation and increased cell death, in turn …
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Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential
… differentiation of vascular smooth muscle cells (VSMCs). The section on biomedical applications of keratin biomaterials focuses on the oxidized form of keratin known as keratose (KOS), because this was the material used for our research. Since we planned to use this material in conjunction with …
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