Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"VSG"”.
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VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control
… variation of the variant surface glycoprotein (VSG) coat. The trypanosome genome contains ~2,000 VSG genes, however only a single VSG gene is transcribed with several expression site associated genes (ESAGs) in a polycistronic transcription unit by RNA-polymerase I, from one of approximately 15 …
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Control Strategy for a Small-Scale Microgrid Based on Battery Energy Storage System-Virtual Synchronous Generator (bess-Vsg)
… the microgrid. By using an effective way of BESS-VSG, which means Battery Energy Storage System-Virtual Synchronous Generator, the frequency can be controlled to the nominal value faster and more smoothly when there is a fluctuation in the PV power generation and/or load change, leading to higher …
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Expression and behaviour of GPI-anchored surface proteins in trypanosomes
… have evolved a variant surface glycoprotein (VSG) coat which underpins a population survival strategy based on antigenic variation. However, the vast majority of trypanosome species do not use this strategy and our understanding of the immune evasion strategies used by these species is far …
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Surface Coat Replacement Dynamics and Antigen Glycosylation in T. Brucei Influence Evasion of the Host Antibody Response
… variation of its variant surface glycoprotein (VSG) coat. During infection, the VSG coat elicits a robust antibody response, but the parasite escapes antibody-mediated clearance by repeatedly accessing its large genomic VSG repertoire and switching expression to antigenically distinct VSGs. Much …
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Tracking the In Vivo Dynamics of Antigenic Variation in the African Trypanosome
… changes its dense variant surface glycoprotein (VSG) coat to avoid elimination by the immune system of its mammalian host, using an extensive repertoire of dedicated genes. Although this process, referred to as antigenic variation, is the major mechanism of pathogenesis for T. brucei, the …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… a murine model of vertical sleeve gastrectomy (VSG), a type of a bariatric surgery. This model recapitulates many of the changes observed in humans after VSG. These include body weight loss, decreases in food intake, decreases in adiposity, improved glucose homeostasis, improved glucose …
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Compensating for the effects of reduced synchronous inertia on frequency stability using virtual synchronous generators
… a disturbance. A virtual synchronous generator (VSG) can compensate for the displacement of synchronous generators by emulating the inertia response and governor response of a synchronous generator. This thesis reviews prior investigations into VSGs and then uses a series of simulations to …
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Analysis of the functions and interactions of RAD51 paralogues in Trypanosoma brucei
… switches in the variant surface glycoprotein (VSG) coat. DNA recombination is critical in this process and a key component of homologous recombination, RAD51, also plays a role in VSG switching. T. brucei encodes four proteins distantly related to RAD51; termed RAD51 paralogues, named RAD51-3, …
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Telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
… a dense layer of Variant Surface Glycoproteins (VSG). The actively transcribed VSG is found in one of ~20 telomeric Expression Sites (ES). Antigenic variation can occur by transcriptional switching, reciprocal translocations, or duplicative gene conversion events between ES. In recent African …
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Characterisation of potential Holliday junction resolvases in Trypanosoma brucei
… mechanisms to stop variant surface glycoprotein (VSG) switching, and hence the parasites ability to evade the host immune system provides a promising opportunity to treat the infection. Holliday junctions are an essential part of homologous recombination, which is used for DNA repair and for the …
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Investigation into the stability of low-inertia micro-grids
… that defines the stability boundary of the multi-VSG MG. A systematic calculation of the Critical Clearing Time is also introduced here to provide a quantitative measure of MG stability to complete the study. The second method to study the MG stability is a proposed convex hull-based trajectory …
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Characterisation of factors that regulate homologous recombination and antigenic variation in Trypanosoma brucei
… switches in the Variant Surface Glycoprotein (VSG) expressed on the cell surface. Such reactions can occur at very high rates (~10-3 switches/cell/generation) and occur primarily by the recombination of VSG genes, selected from an enormous silent archive, into specialised expression sites. It …
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Antibody phage-displayed libraries derived from chicken immunoglobulin genes : a source of highly specific diagnostic antibodies
… trypanosome variable surface glycoprotein (VSG) and malignant catarrhal fever virus (MCFV) each chicken produced egg yolk antibodies (IgY) against four of the five antigens. Using phage display technology, two single-chain variable fragment (scFv) antibody libraries, one with the …
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Antigenic Variation and Telomere Structure in Trypanosoma brucei
… changing the variant surface glycoprotein (VSG). From the ~1000 VSG genes (VSGs) scattered throughout the genome, a few are located at telomere loci called expression sites (ESs) and only one is expressed at any time, suggesting a stringent regulatory mechanism. Here, it is demonstrated that …
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Synthetic strategies for potential trypanocides
… have a variable surface glycoprotein (VSG) coat, which allows them to evade the human immune system. The GPI anchor attaches the VSG to the cell membrane; therefore inhibiting GPI synthesis should expose the parasite to the immune system. Initially, large substrate analogues were …
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Histone Modifications in Trypanosoma Brucei
… variation. Variant surface glycoproteins (VSG), the surface antigen, are expressed from genes located at as many as 20 Expression Sites (ES), which are present in subtelomeric regions of several chromosomes. How trypanosomes maintain monoallelic expression of VSG is a major question in …
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The influence of satiety mediators and dietary intake on food addiction in obese women prior to sleeve gastrectomy: a pilot study
… obese women before vertical sleeve gastrectomy (VSG). Seventeen morbidly obese females were recruited from Houston Methodist Hospital, Houston, Texas. The Yale Food Addiction Scale (YFAS) questionnaire, a 24hour dietary recall, and fasting blood were obtained during a presurgery appointment. …
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On the performance and capacity of space-time block coded multicarrier CDMA communication systems
… schemes, multicode, variable spreading gain (VSG) and multiple symbol rate (MSR), are investigated. Next, the thesis looks into some of design and implementation issues of STBC MC-CDMA systems. First, the timing and frequency synchronization is studied. A subspace-based blind joint timing and …
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Capacity Building of Voluntary Security Group: A case study of Mbezi Salasala Kilimahewa Community in Kinondoni District, Dar es salaam, Tanzania
… general. Efforts taken include, formation of a VSG which is a Sungusungu group which lack security skills and is facilitated by only few people (Water Users Association only), therefore through this Participatory Assessment, this project came up with the following objectives: first, to increase …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
… 65 and a soluble Variant Surface Glycoprotein (VSG) were selected for development into a lateral flow format and 80 randomised patients’ sera were used to evaluate these prototypes. Here we describe the results showing that un-optimised proto-type lateral flow tests match the reported CATT …
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