Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"VPS35"”.
-
Biochemische und zellbiologische Charakterisierung des Retromer-vermittelten Proteintransports in Pflanzen
… besteht aus zwei Subkomplexen, einem großen aus Vps35, Vps26 und Vps29 und einem kleinen aus Vps5 und Vps17 (vps für vacuolar protein sorting). Während der größere vermutlich die Frachtauswahl bedingt, ist der kleinere möglicherweise für die Vesikelbildung verantwortlich (Seaman et al., 1998). …
-
Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
… PD-associated pathways, including LRRK2 and VPS35. With the presence of p-Ser111 Rab8A, the ability of LRRK2 to phosphorylate Rab at Thr72 was significantly reduced both in vitro and in cell-based experiments. This demonstrated the first evidence of cross-talk between PINK1 and LRRK2 …
-
Functional Connection Between Yeast Dynamin and Retromer at the Endosome
… 5 VPS proteins (Vps5, Vps17, Vps26, Vps29, and Vps35). Retromer acts as the coat proteins for vesicles emerging from late endosomes. Loss of Retromer function has been previously implicated in both Parkinson's and Alzheimer's disease. Vps1, a yeast dynamin-like protein, plays a role in …
-
Structure/Function Studies on Vps9 domain-containing Ankyrin Repeat protein (VARP)
… Vps29. The retromer core complex, comprising Vps35, Vps26, and Vps29, utilises different SNX proteins to mediate both Endosome to Golgi traffic, and Endosome to Plasma membrane traffic. The interaction of Varp with Vps29 localises Varp to endosomal membranes. Varp has two ‘zinc knuckle’ …
-
The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… the effects of genetic overexpression of VPS35, the backbone of the retromer core, in trisomic neurons. We observed similar decreases in AD pathology measures, however, the magnitude of the effect was smaller with genetic overexpression than with pharmacological stabilization using …
-
Heredity in Parkinson's disease. From rare mutations to common genetic risk factors.
… was examined. The SNCA, LRRK2, EIF4G1, VPS35, PINK1, ATXN2 and ATXN3 genes were analyzed in all probands; the PARKIN, PINK1 and DJ1 genes were tested in a subgroup of 23 patients with young onset or marked heredity. DNA from the brain tissue of 7 patients with parkinsonism was also …
-
PROTEINi screens identify ORP9 as a novel regulator of KRAS-driven signalling
… be involved in KRAS trafficking. Knockdown of VPS35, a retromer subunit, significantly inhibited KRAS-driven activation of the downstream pathway and expression of GFP, suggesting KRAS is a potential cargo of the retromer. The results presented in this thesis suggest that ORP9 is a novel …
-
DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
… for the retromer complex at the critical Vps35-Vps29 interface, thereby bolstering their potential therapeutic efficacy. Concurrently, I rigorously pursued strategies to minimize off-target effects, particularly concerning interactions with the 5-HT receptor class, thus striving to enhance …
-
Estudio de factores genéticos y otros marcadores moleculares en la enfermedad de Parkinson
… altamente penetrantes en los genes SNCA, LRRK2, VPS35, PRKN, PINK1 y DJ1, relacionadas con la EP monogénica. Por otro lado, variantes comunes en 90 loci de riesgo explican en su conjunto entre el 16-36% del riesgo heredado de EP idiopática. A pesar de que nuestro conocimiento sobre las bases …
-
Caracterización genómica, proteómica y de la virulencia de aislamientos clínicos de Cryptococcus neoformans var. Grubii : efecto del hierro y el cobre
… con el estrés celular, tráfico vesicular (Ap-1, Vps35), estructura de la pared celular (Och1, Ccr4, Gsk3), biosíntesis de pigmento (Hem15, Mln2), reparación de ADN (Chk1), transporte de proteínas (Mms2), así como proteína asociada a la SUMOilación (Uba2) y un transportador mitocondrial (Atm1). …