Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"VPA"”.
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Metabolism and pharmacokinetic studies of valproic acid using stable isotope techniques
Valproic acid (VPA) is an anticonvulsant agent widely used in the treatment of several types of epileptic seizures. The drug is unique within its therapeutic class, in terms of its mechanism of action, its chemical structure, as well as its extensive biotransformation into at least 16 different …
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Placental epigenetic modifications and development in valproic acid-induced teratogenesis
Valproic acid (VPA) is an anti-epileptic and a teratogen. In utero exposure to VPA is associated with congenital malformations and neurodevelopment disorders. VPA exerts its teratogenic effects through epigenetic dysregulation, which interferes with tissue development and function. Evidence …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… drugs on the market, including valproic acid (VPA), have a wide range of therapeutic effects in addition to treating epilepsy. In recent years, the use of VPA in the treatment of psychiatric conditions has been on the rise. However, studies have shown that in utero exposure to VPA can have …
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A Nomogram for Valproic Acid and the Effect of Missed Doses
… For a neuropsychiatric agent like valproic acid (VPA), rational dosing recommendations are of particular importance. VPA is subject to therapeutic monitoring using total concentrations. Due to non-linear binding of VPA to plasma proteins, current dose titration schemes for VPA are empirical. The …
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Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
… study was to evaluate the ability of valproate (VPA) to improve efficacy of chemotherapeutic regimen in SCLC. We show that VPA directly induces apoptosis of SCLC cell lines at concentrations relevant for clinical uses. Furthermore, VPA synergizes with two chemotherapeutic regimen used in first …
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What is the relationship between vigorous physical activity and physical and mental health indicators in young adults?
… recommend regular vigorous-intensity PA (VPA), unlike guidelines for adolescents. This thesis aimed to conduct a systematic review to ascertain the influence of VPA on anxiety, body mass index [BMI], and blood pressure [BP] in young adults. Literature searches were conducted in PubMed, …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
… <p>Previous studies have shown that valproate (VPA), a branched chain fatty acid that has been successfully used for the treatment of bipolar disorder, epilepsy, and migraine, causes inositol depletion by inhibiting MIPS in vivo but not in vitro, which suggests that inhibition is indirect. …
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Μελέτη της επίδρασης του βαλπροϊκού νατρίου στη διεργασία της ήβης, στη συμπεριφορά ενεργητικής αποφυγής και στις βιολογικές αμίνες του εγκεφάλου, υπό χρόνια και οξεία χορήγηση και από επίδραση stress: Πειραματική εργασία σε επίμυες
The effect of VPA on the process of puberty, on conditioned avoidance behaviour learning and on brain neurotransmitters of the rats was studied, after chronic and acute administration of the drug and after stress. The brain neurotransmitters NA, DA, DOPAC, (DOPAC/DA), 5-HT, 5HIAA, (5HIAA/5-HT) were …
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Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen
… Stimmungsstabilisatoren Lithium und Valproat (VPA) im Rattenhirn sowohl die Cyclooxygenase (COX)-2-Synthese als auch die Prostaglandin E2 (PGE2)-Ausschüttung reduzieren. Aufbauend auf dieser Beobachtung sollten in dieser Arbeit die Effekte der Stimmungsstabilisatoren Lithium, Lamotrigin und …
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A prefrontal source of visual target enhancement in the macaque area V4
The ventral pre-arcuate area (VPA) in the primate prefrontal cortex has recently been found to play an important role in feature-based selection of visual targets in the context of a naturalistic free-gaze visual search task. While VPA neuronal activation was found to be necessary for behavioral …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… class I selective HDAC inhibitor, valproic acid (VPA), to identify hdac3 as an essential mediator of primitive hematopoiesis. Exposure to VPA during gastrulation results in a marked and specific block of primitive hematopoiesis in Xenopus embryos. Furthermore, pharmacological and loss of function …
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Neuromolecular basis of anomalous feeding behaviour in the valproate rat model of autism
… to the antiepileptic drug, valproic acid (VPA), leads to autism. The prenatally VPA-exposed rats are model organisms to study ASD and they show ASD-like symptoms of, among others, elevated anxiety and decreased social interaction. Importantly, very little is known about appetite control in …
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Neurotrophic Theory of Accelerated Temporal Cortex Maturation in the Valproic Acid Rat Model of Autism
… to the autism-linked teratogen valproic acid (VPA). My overarching hypothesis was that the slow maturation of TeA neurons during the first three weeks of postnatal development is a result of low local production and/or secretion of brain derived neurotrophic factor (BDNF), and that VPA can …
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Measuring the Functionality of Amazon Alexa and Google Home Applications
Voice Personal Assistant (VPA) is a software agent, which can interpret the user's voice commands and respond with appropriate information or action. The users can operate the VPA by voice to complete multiple tasks, such as read the message, order coffee, send an email, check the news, and so on. …
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Valproic Acid-Induced Teratogenesis in Japanese Rice Fish (Oryzias Latipes) Embryogenesis
Valproic acid (VPA) was introduced as an antiepileptic in 1967 in France and it has become the most prescribed anticonvulsive drug therapy worldwide since then. In the clinic, valproic acid is selected to treat absence seizures, myoclonic seizures, generalized tonic-clonic seizures, atonic attacks …
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An Analysis and Comparison of WMS-III and WMS-IV Verbal Paired Associates: Practical Implications for Neuropsychologists
… outpatients on the Verbal Paired Associates (VPA) subtest from current and prior versions of the Wechsler Memory Scale (WMS). It was predicted that VPA from the WMS-III (VPA3) would be similar in agreement to the WMS-IV (VPA4) and that VPA4 would show a stronger relationship than VPA3 with …
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Left Ventricular Diastolic Function in Adolescents with Overweight and Obesity: The Moderating Influence of Physical Activity, Cardiorespiratory Fitness, and Metabolic Health
… this question. Vigorous physical activity (VPA) was the only PA intensity associated with LVDF, with the strongest links to septal TDI. Mediation analyses revealed that higher VPA had a direct benefit on LVDF as well as an indirect effect through decreased adiposity. This study also …
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The value of catch statistics and records of Guano Harvests for managing certain South African Fisheries
… approach to Virtual Population ·Analysis ( VPAl is adopted, developed, and implemented. It is shown from results obtained using artificial fisheries data that the database conventionally considered adequate for VPA work, viz. the catch mass and age structure, does not lead to reliable …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… hydroxamic acid (SAHA) and valproic acid (VPA) were investigated in in vitro and in vivo models of PD. Neither inhibitors protected dopaminergic cell lines, SH-SY5Y and N1E-115, against hydrogen-peroxide (H2O2) and MPP+-induced toxicity. Except, at the highest concentrations (10-3M), where …
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The status and productivity of the Cape hake stock off the west coast of South Africa based on an age-structured production model with different stock-recruitment and fishing selectivity-at-age relationships
The surplus production model and ad hoc tuned VPA assessment methods currently used to provide the basis for scientific TAC recommendations for the Cape hake resource off South Africa provide rather different appraisals of the current status and productivity of this resource. The production model …
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