Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"VLP vaccine"”.
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Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
… accurate, and precise, preclinical evaluation of vaccine efficacy. Similarities in gastrointestinal anatomy, physiology, and immune system allows for direct translation of results from Gn pigs to humans. Commercially available HRV vaccines perform significantly poorer in low- and middle- income …
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Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice
… the great need to develop a prophylactic HIV vaccine. The manufacture of a vaccine has proven difficult though, with a number of successful designs in animal models having little success in humans. In view of this, there has been a need for novel vaccine approaches that are able to elicit …
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Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens
… industry. In this study, virus-like particles (VLPs) were produced using Agrobacteriummediated transient protein expression in Nicotiana benthamiana plants as potential vaccines against IBV. Modifying the full-length IBV Spike (S) protein resulted in high levels of VLPs resembling native IBV …
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Plant production of Gonococcal peptide vaccine, candidate peptide display with HPVs
… to sexually transmitted infections. While vaccines targeting HPV have seen success, an effective vaccine against gonorrhea remains elusive, as antimicrobial resistance continues to be a growing threat. This study explores the innovative approach of plant-based production for a dual vaccine …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
… heterogeneity over the years, making a vaccine solution ever so challenging. Modified live-attenuated vaccines (MLVs) have been the most common approach, but the long-term safety regarding their potential for pathogenic reversion still needs to be addressed. Subunit based vaccines have …
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Investigation of particulate Bluetongue virus vaccines made in plants
… limited serological cross-reactivity. Current vaccine strategies include live attenuated and inactivated vaccines. Although they have been successful in protecting animals, there are many limitations and risks associated with these vaccine strategies such as reversion to virulence, …
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The Immunogenicity of Plant-produced Human Papillomavirus (HPV) Virus-like particles (VLPs) in Mice
… can self-assemble into virus-like particles (VLPs) that are structurally like native virions, which is the foundation on which commercially available vaccines have been developed. There are 3 commercially available HPV vaccines that are effective at preventing HPV infections, but are …
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Investigating Genetically Engineered Virus-Like Particles Using Molecular Dynamics Simulations for Enhanced Vaccine Development
Virus-like particles (VLPs) mimic the structure of viruses without containing viral genetic material, making them safe and highly immunogenic platforms for vaccine development. Genetic modifications can expand the use of VLPs, such as the insertion of antigens to target various diseases. However, …
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Development of plant-produced African horse sickness vaccines
… warming and climate change. Live attenuated vaccines (LAV) have been used with relative success for many decades, but carry the risk of reversion to virulence and/or genetic re-assortment between outbreak and vaccine strains. Furthermore, the vaccines lack DIVA capacity, the ability to …