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Showing 1 to 4 of 4 for “"VKORC1"”.
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The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
… Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 and VKORC1 exhibit genetic polymorphisms that have been shown to affect warfarin response and favorably facilitate warfarin dosing and improve clinical outcomes. However, none of these studies …
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The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population
… for 5 single nucleotide polymorphisms (SNPs), VKORC1 c.-1639G>A, VKORC1 c.1173C>T, VKORC1 c.3730G>A, GGCX c.1218C>T and GGCX c.1242C>T. Results: We report an association of age with warfarin dose, where, older patients had lower dose requirements (p>0.001 in MA; p>0.042 in SAB). Higher BMI was …
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Molekulare Ursachen Vitamin K-abhängiger Gerinnungsstörungen
… Komponente der Vitamin K-Epoxid-Reduktase (VKORC1), die den Recycling-Prozess von Vitamin K im sog. Vitamin K-Zyklus katalysiert. Die Charakterisierung des VKORC1-Proteins umfasst dessen subzelluläre Lokalisation, den Vergleich orthologer Proteine in verschiedenen Species und die …
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
… proteins. Genetic variants in CYP2C9 and VKORC1 have been extensively studied on how they affect warfarin dose variability, culminating in several dosing algorithms incorporating genetic (i.e., CYP2C9*2, CYP2C9*3 and VKORC1 g.-1639G>A) and non-genetic factors (i.e., age, body surface area, …