Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"VH"”.
-
The VH repertoire and clonal diversification of B cells in myositis and vasculitis
Autoimmune inflammatory reactions occur in a number of disorders to a variety of self antigens but the precise cellular and molecular mechanisms resulting in pathology are largely unresolved. In some instances T cell mediated reactions are thought to be the main contributors to disease mechanisms …
-
Thematic analysis of influencers on continuing professional learning of tenure track engineering faculty as assistant professors at an RU/VH institution
<p>“Although the need for lifelong learning of professionals is stressed through university education, the patent differences between learning as a student, within a controlled framework focusing on accessible outcomes, and learning as a professional have not been clarified” (Webster-Wright, 2009, …
-
Identification of demographics and comorbidities associated with Vascular Hamartomas
Vascular hamartomas (VH) are tumor like growths that typically appear in infants and manifest as a blemish on the skin. The goal of this study is to substantiate clinical data on the demographic characteristics and discover comorbid conditions associated with VH. Previous clinical data suggests …
-
Studies on the efficient intracellular delivery vehicle using variable region domain of a cell-penetrating anti-DNA monoclonal antibody
… we have produced the protein of recombinant VH domain of a monoclonal anti-DNA antibody 2C10, IgG of which has been previously shown to have cell-penetrating activities for studying the applicability of the domain as a cellular delivery vehicle. To evaluate the cell-penetrating property of …
-
Etablierung einer Fluoreszenz-Multiplex-Polymerase-Ketten-Reaktion zur semiquantitativen und qualitativen Analyse des V H-Repertoires in humanen B-Lymphozyten
Mit der VH-Fluoreszenz-Multiplex-PCR steht ein neuartiges Screeningverfahren zur semiquantitativen und qualitativen Analyse der VH-Familienverteilung der schweren Kette des Immunglobulinmoleküls in humanen B-Lymphozyten zur Verfügung. In zwei Multiplex-PCRs werden IgH Produkte der sechs häufigsten …
-
Structural study of human antibody fragments with specificity for Mucin-1 antigen
… fragment, the crystallization of a human VH fragment has been achieved. The fragment was derived from the human single chain antibody scFvM12, which recognizes the cancer-specific hypoglycosylated MUC1. The human M12-VH domain has been crystallized through limited in-vitro proteolysis of …
-
The Relationship Between Volumetric Plaque Components and Classical Cardiovascular Risk Factors and the Metabolic Syndrome
… virtual histology-intravascular ultrasound (VH-IVUS). Background: It remains unclear how the cardiovascular risk factors correlate with the histological components of coronary plaques. Methods: “Whole vessel” VH-IVUS analysis was performed in 189 vessels of 63 patients. The components of …
-
Co-diagnosis Frequency of Peripheral Vestibular Disorders and Physical Therapy
… vertigo (BPPV) and vestibular hypofunction (VH). Physical therapy (PT) is an effective component of the medical management for both conditions. The occurrence rate of concurrent BPPV and VH in the same patient has not been described in the literature. Identifying patients with co-diagnosis of …
-
Stochastic flow and transport through multifractal porous media
… effects on the spectra of the hydraulic gradient VH and specific discharge q when (Y2 exceeds unity. In this thesis we study flow and transport when the hydraulic conductivity K is an isotropic lognormal multifractal field. Unlike the perturbation approach, results obtained are nonlinear even …
-
Structural analysis of LMO2 for the development of a small molecule inhibitor
… with an antibody single domain termed VH#576, and purified to a high yield and purity. A final construct of LMO2, spanning residues 9 to 147, bound to VH#576 has been crystallised and the structure solved, to a medium resolution of 3.3Å, using phase information from single anomalous …
-
The Distribution of opiates, cocaine and their metabolites in skeletal muscle tissue and vitreous humour as an aid to post-mortem toxicological interpretation.
… activity, e.g. muscle and vitreous humour (VH), have the potential to provide more reliable post-mortem toxicological specimens. In the absence of a blood sample the toxicologist may have to rely on such tissues yet few studies have been undertaken to examine the relationship between drugs …
-
hs-CRP level represents the disease burden and the age but not vulnerability of coronary atherosclerosis
… virtual histology-intravascular ultrasound (VH-IVUS) in 189 vessels of 63 patients. The components of atherosclerosis were classified as fibrous (FI), fibrous-fatty (FF), necrotic core (NC) and dense calcium (DC). Quantitative assessment of these plaque components and the presence of …
-
Profilometry with volume holographic imaging
… terrace profiling, etc. The Volume Holographic (VH) lens is a novel optical element which process the incident light field in a 3D fashion. It has been shown with promising applications in object profile acquisition and 3D imaging areas. In this thesis, we propose, design and implemented a number …
-
Characterization of anti-DNA antibody with Tat peptide sequence in CDR
… 아미노산으로 구성된 Tat 펩티드 (GRKKRRQRRRPPQ)를 3D8 scFv의 VH-CDR1, VH-CDR2 및 VH-CDR3부위에 교체, 삽입된 scFv 변이체를 클로닝한 후, 단백질을 박테리아세포에서 발현, 정제하였다. 세 종류의 변이체 중에서 수용성 단백질로서의 발현률이 가장 높은 VH-CDR3 부위가 Tat으로 교체된3D8 scFv 변이체 (3D8s-HC3/Tat)의 DNA 결합력, DNA 가수분해능력, 세포내 침투능, 및 핵내로의 이동여부를 조사하였다. ELISA 및 SPR (surface plasmom …
-
Engineering of recombatinant antimalria antibodies for application in paratransgenesis
… constructed, with varying linker length, in the VH-VL and VL-VH orientation. The scFvs were cloned into different expression plasmids to evaluate a suitable expression system. The orientation of the variable domains on secretion of the scFv 4B7 was investigated. No secretion was observed for the …
-
Variable horizon model predictive control: robustness and optimality
Variable Horizon Model Predictive Control (VH-MPC) is a form of predictive control that includes the horizon length as a decision variable in the constrained optimisation problem solved at each iteration. It has been recently applied to completion problems, where the system state is to be steered …
-
Delayed access to feed affects broiler small intestinal morphology and intestinal cell ontogeny
… morphology, which includes villus height (VH) and crypt depth (CD), and to quantify changes in regulatory genes, such as Olfactomedin 4 (Olfm4), Marker of Ki-67 (Ki-67), Peptide Transporter 1 (PepT1), and Mucin 2 (Muc2), in response to DAF. The Olfm4 mRNA can clearly identify stem cells in …
-
The development and validation of an ABL835 FLEX Blood Gas Analyser method for the quantitation of glucose, lactate, and electrolytes in post-mortem vitreous humour
… at the time of death. Vitreous humour (VH) has an anatomically isolated location within the body, making it less prone to the effects of putrefaction and autolysis after death. As such, VH has frequently been described as the specimen of choice in biochemical forensic investigations to …
-
Effect of disruption of 3D8 complementarity-determining regions on properties of 3D8 antibody
… domain of heavy or light chain in scFv format), VH (H-CDRi; inactivated-CDR of variable domain of heavy chain single domain format), and VL (L-CDRi; inactivated-CDR of variable domain of light chain single domain format) by replacing the amino acid sequence of each CDRs with (GlySer)n of same …
Page 1 of 4