Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"VEGFR1"”.
-
Predicting angiogenic receptor trafficking and signaling via computational systems biology
… biology, I have previously predicted that VEGFR1 acts as a predictive biomarker of anti-VEGF efficacy in breast cancer. Particularly, tumor endothelial cell subpopulations exhibiting high VEGFR1 levels result in ineffective anti-VEGF treatment. These high VEGFR1 subpopulations are …
-
Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
… receptor vascular endothelial growth receptor (VEGFR1/Flt-1), has been implicated in cervical carcinogenesis, yet their expression patterns across lesions to disease are poorly characterised. This study evaluated the expression patterns of PLGF and its receptor VEGFR1/Flt-1 across cervical …
-
The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis
… and invasion by secreting VEGF-A that binds to VEGFR1, a processrequired for tumor growth and metastasis in mice and correlated with a poorprognosis in lung adenocarcinoma patients. In this study, we discovered thatmiR-200 blocked CAF-induced tumor cell invasion by directly targetingVEGFR1 in …
-
Multiplexed angiogenic biomarker quantification on single cells
… having high concentrations of membrane VEGFR1, VEGFR2, EGFR, IGFR, and PDGFRs. To gain greater insights into cell heterogeneity and examine angiogenic signaling pathways as a whole, I utilize the unique spectral properties of quantum dots (Qdots), and combines Qdots with qFlow cytometry, …
-
Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
… survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows PRH can control cell survival through the modulation of VEGF and VEGF receptor signalling. CK2 is a stress-activated protein kinase with …
-
Pregnancy associated progenitor cells migrate, integrate and contribute to maternal hematopoietic compartments in the murine model
… of major growth factor and chemokine receptors VEGFR1, c-Kit and CXCR4 on PAPCs during gestational and postpartum timepoints which may explain the migratory patterns of PAPCs to maternal tissues, injuries and neoplastic transformations. In addition, presence of VEGFR1+ CD34+ and VEGFR1+ CD133+ …
-
Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… to and activates two primary VEGF receptors, VEGFR1 and VEGFR2. VEGFR2 is the primary angiogenic receptor, while the function of VEGFR1 is less defined. It is important to note that the VEGFRs are expressed on endothelial cells, tumor cells and on many host immune cells. Therefore, to better …
-
Discovering angiogenic cell signaling landscapes: Quantitative mapping through experiment and computation
… kinetics for VEGF-A165, -A165b, and -A121 with VEGFR1 and –R2 using (SPR). I find that the VEGF-A variants differentially bind VEGFRs. VEGFR1 binds variants at strengths: VEGF-A165a > -A165b > -A121; and VEGFR2 binds variants at strengths: VEGF-A165b > -A165a > -A121. Interestingly, my findings …
-
The effect of RAN inhibition on human colorectal cancer cells (CRC)
… treatment and exert inhibition on Akt 1/2/3 and VEGFR1/2 mRNA levels. In conclusion; MBZ which is a Ran inhibitor, has significantly reduced proliferation, colony formation, and migration in colorectal cell lines with K-Ras and Pten gene deletion compared to wild type cells in a dose-dependent …
-
Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
… increased expression of angiogenic receptors VEGFR1, VEGFR2, and EphA7, in addition to increased production and secretion of laminin, a tubule-associated extracellular matrix protein. The incorporation of QK, a synthetic angiogenic peptide, was also shown to promote endothelial cell …
-
Quantitative methods to regulate angiogenesis: applications to cancer and cardiovascular disease
… for tuning angiogenesis, are more sensitive to VEGFR1 cell surface levels than VEGFR2; updating VEGFR1 levels in the tumor model gave a 64% change in free VEGF levels in the blood compartment, whereas updating VEGFR2 levels gave a 17% change. Furthermore, we find that subpopulations of tumor …
-
Vascular Endothelial Growth Factor In Cortical Development
… and differentiation. Vegf and its receptors (VegfR1, VegfR2, Nrp1, and Nrp2) are expressed in many of the cell types critical for neurogenesis and angiogenesis.</p> <p>The Vegf gene is expressed as three main isoforms in the mouse brain, and these isoforms have distinct biochemical properties …
-
p53 Functional Interactions: the Study of a New Crosstalk with Estradiol Pathway in Transcriptional Responses to Chemotherapeutics
… instead discovered for the angiogenesis related VEGFR1, FLT1 promoter. MAIN TASK: Transcriptional cooperation between p53 and ERs was sought out on a global scale using the human breast adenocarcinoma MCF7 cells as a model and transcriptome analyses. Cells were subjected to single or …
-
Estudio de la acción antitumoral de diversos derivados de la mitracina
… nivel de gen, como de proteína de los receptores VEGFR1 y VEGFR2 que juegan un papel clave en este proceso de angiogénesis. CONCLUSIONES Concluimos por tanto que DIG-MSK es un fármaco muy prometedor, que mantiene y mejora las capacidades antitumorales de su molécula de origen la MTA, con …