Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"VEGFR"”.
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VEGFR-3 and Tie pathways in vascular network formation
… therapeutic value in conditions of tissue edema. VEGFR-3 is present on all endothelia during development, but in the adult its expression becomes restricted to the lymphatic endothelium. VEGF-C and VEGF-D are ligands for VEGFR-3, and potently promote lymphangiogenesis in adult tissues, with direct …
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Die Rolle des Tyrosinkinase-Rezeptors VEGFR-2 im neuronalen Kontext
… dieser Arbeit wurde die Rolle des Rezeptors VEGFR-2, Flk-1, im neuronalen Kontext untersucht. In einem ersten Schritt wurde in embryonalen Stammzellen der Maus das fluoreszierende Protein eGFP unter der Kontrolle regulatorischer Sequenzen des flk-1-Promotors, -Enhancers exprimiert. Nach der …
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유두상갑상선미세암에서혈관내피성장인자(VEGF),혈관내피성장인자수용체-1(VEGFR-1),저산소증유발인자(HIF-1a)의mRNA발현
… (vascular endo-thelial growth factor receptor-1,VEGFR-1), VEGF의 발현을 유도하는 저산소증 유발인자(Hypoxic induced factor 1α, HIF-1α), 각각의mRNA발현정도를 분석하여 신생혈관생성의 발현형의 변화여부를 확인하고 여러 임상 및 병리적 특징과 VEGF mRNA의 발현정도와의 상관관계를 분석 하기 위하여 시행되었다. 대상 및 방법: 유두상 갑성선암 진단 하에 갑상선절제술을 시행한 환자 중 종양의 크기가 10mm이하인14명의 환자를 대상으로 수술 중에 …
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Regulation of VEGFR-3 expression and lymphangiogenesis in normal and inflamed tissues
Elevation of VEGFR-3, the primary mediator of lymphangiogenesis (i.e., new lymphatic vessel formation), is frequently associated with inflammation related to chronic disease and cancer. In the latter case, VEGFR-3 dependent lymphangiogenesis induced by inflamed tumors increases the incidence of …
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Expression of Vascular Endothelial Growth Factor-A and its Receptors in Uteroplacental Tissues of the Normotensive and Hypertensive Pregnant Rat
… vascular endothelial growth factor receptor 1 (VEGFR-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) in normal rat uteroplacental tissues at early, mid and late gestation. The second aim of this project was to measure expression of VEGF-A, VEGFR-1 and VEGFR-2 in uteroplacental …
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Correlación entre los datos clínico-patológicos y la expresión de los marcadores inmunohistoquímicos c-MET, IGF-1R y VEGFR-2 como factores pronósticos en el adenocarcinoma gástrico
… HIPÓTESIS La expresión de c-MET, IGF-1R y VEGFR-2 en el tejido gástrico tumoral puede tener un valor pronóstico de recurrencia en adenocarcinoma gástrico y podría relacionarse con variables clínicas y patológicas. OBJETIVOS Determinar mediante inmunohistoquímica el grado de expresión de los …
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Expression of Vascular Endothelial Growth Factor(VEGF), Vascular Endothelial Growth Factor Receptor-1(VEGFR-1), Hypoxic Induced Factor-1alpha(HIF-1α) mRNA in Papillary Thyroid Microcarcinoma(PTMC)
… vascular endothelial growth factor receptor-1(VEGFR-1), hypoxic induced factor-1alpha(HIF-1α) mRNA expression in PTMC. MATERIALS & METHODS: VEGF, VEGFR-1, HIF-1α mRNA expression was examined by RT-PCR in 14 patients who had undergone thyroidectomy due to PTMC. The thyroid tumor tissue and …
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Targeting Nanoparticles to Tumor Vasculature
… molecules identified as tumor vascular markers: VEGFR-2, phosphatidylserine (PS), and phosphatidylethanolamine (PE). To target VEGFR-2, I have used Fab' fragments derived from a series of rat monoclonal antibodies (RAFL) that bind to the extracellular domain of the receptor. For PS targeting, I …
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Μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 και συσχέτισή τους με την οδό μεταγωγής σήματος EpoR/ JAK-2/ STAT-5 στους όγκους εγκεφάλου του ανθρώπου
… και VEGF-D οι οποίοι μέσω του υποδοχέα τους VEGFR-3 (υποδοχέας κινάσης τυροσίνης) έχει βρεθεί ότι προάγουν την αγγειογένεση στα νεοπλάσματα αυτά, ο στόχος της παρούσας εργασίας είναι η μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 …
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Immunhistologische Charakterisierung experimenteller Lymphangiome der Maus
… sowie gegen Podoplanin, Meca32 und VEGFR-2, ein vaskulärer Wachstumsfaktorrezeptor, wurde die Häm- und Lymphangiogenese untersucht. Dabei zeigte sich, dass Blut- und Lymphgefäße kontinuierlich vom Diaphragma ausgehend in die Tumoren vorgedrungen waren. VEGFR-2-Expression konnte in …
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
… of each tumor was evaluated by staining for VEGFR-3 and D2-40 and correlated with cervical LNM state. Ultrasound features were evaluated to compare the differences between these two groups. Larger tumor size, multiplicity, extrathyroid extension were more common in group 2 (p<0.05). The …
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Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
… the expression of VEGF-A, its receptors VEGFR-1 and VEGFR-2 as well as PTEN and SHP1 in childhood ALL using immunohistochemistry. We observed that the expression of VEGFR-1, PTEN and SHP1 in mononuclear cells of children with ALL were significantly different to the expression of …
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Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
… elastin, fibronectin,Langerhans cells and VEGFR-3. Murine markers included collagen type IV, laminin,fibronectin, Langerhans cells and VEGFR-2. Staining intensities were quantified and statistically analysed using one-way ANOVA with subsequent Friedman’s test for multiple comparisons. Since …
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Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
… receptor vascular endothelial growth receptor (VEGFR1/Flt-1), has been implicated in cervical carcinogenesis, yet their expression patterns across lesions to disease are poorly characterised. This study evaluated the expression patterns of PLGF and its receptor VEGFR1/Flt-1 across cervical …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
… Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1) and p85 subunit of PI3K. All these events lead to increase of BBB permeability and bacterial invasion of microvascular endothelial cells. It is still unknown if the emergency of invasive Hia disease is due to the serotype replacement after …
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Adipogenesis and angiogenesis : roles in tissue engineering and glucose metabolism
… are mutually dependent via a VEGF receptor 2 (VEGFR2)-mediated mechanism. Since then several other studies have reinforced a role for the VEGF-VEGFR system in energy metabolism. For example, genetically obese mice treated with anti-VEGF antibody had lower fat pad weights, but the VEGF receptor …
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Molecular Studies on Pathogenesis, Prognostic Factors, and New Treatment Options for Ovarian Granulosa Cell Tumors
… We found that VEGF and its functional receptor VEGFR-2 are highly expressed in GCTs; VEGFR-2 was also expressed in the active, phosphorylated form. GCTs produced significant amounts of VEGF that could also be detected in the serum of GCT patients. In cell culture assays, the inhibition of VEGF …
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Συστηματική ανασκόπηση: αποτελεσματικότητα και ασφάλεια των αναστολέων κινάσης τυροσίνης στο χολαγγειοκαρκίνωμα / Efficacy and safety of tyrosine kinase inhibitors in cholangiocarcinoma: a comprehensive systematic review
… μήνες και ORR από 15,6% έως 50%. Αντίθετα οι VEGFR/multikinase (αντιαγγειογενετικοί) αναστολείς καθώς και οι EGFR στοχευμένοι αναστολείς παρουσίασαν σημαντική ετερογένεια αποτελεσμάτων και κατά κανόνα χαμηλότερα ποσοστά ανταπόκρισης εκτός ορισμένων συνδυαστικών σχημάτων. Οι συνδυαστικές …
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… vascular endothelial growth factor receptor 2 (VEGFR-2) blockade. The combination of both modalities normalized tumor vasculature and led to an accumulation of DNA damage yielding a significant delay in tumor growth. In contrast to prior observations in other cancers, the combination did</p> …
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Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
… PlGF-/- astrocytes overexpress VEGF receptor-2 (VEGFR-2) which through activation of the ERK1/2 signaling pathway leads to a more proliferative astrocytic phenotype. These astrocytes were more resistant to oxygen and glucose deprivation (OGD) than PlGF+/+ astrocytes, a characteristic that was …
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