Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"VEGF-C"”.
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The effect of brain-specific VEGF-C deletion on vascular morphology in the brain and skull
Vascular endothelial growth factor C (VEGF-C) promotes mainly lymphangiogenesis, but it can also stimulate angiogenesis by binding to VEGFR3 and VEGFR2 on endothelial cell surface. We studied VEGF-C expression by β-galactosidase staining in VegfcLacZ/+ mice. This revealed Vegfc expression in …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
… including vascular endothelial growth factor-A (VEGF-A), VEGF-C and AZD2171, a tyrosine kinase inhibitor of the VEGF receptors, were tested as radiation sensitizers and protectors. Our results indicate that VEGF-A and VEGF-C are radiosensitizers while AZD2171 did not modulate the radioresponse. …
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Lymphatic pathophysiology of tumors
… whether Vascular Endothelial Growth Factor-C (VEGF-C), a lymphangiogenic factor, was sufficient to induce lymphatic function in tumors. The overexpression of VEGF-C in tumors leads to an increase in lymph node metastasis as well as structures that positively stain for lymphatic markers, but …
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Novel mechanisms for buffering the haemodynamic effects of dietary salt and the relevance of skin sodium in humans
… by vascular endothelial growth factor-C (VEGF-C), both attenuating the rise in BP. This represents an additional system for maintaining BP and volume homeostasis in response to salt load. The focus of this thesis is to determine whether these dermal mechanisms exist in humans. Methods: The …
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… spread and re-growth of colorectal cancer (CRC). VEGF-A is one of the most studied angiogenic agents. A significant degree of the morbidity and mortality associated with colorectal cancer is related to the degree of tumour vascularity. As a consequence, considerable research has been undertaken in …
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Vorläuferzellen des lymphatischen Endothels
… der Lymphgefäße wird durch den Wachstumsfaktor VEGF-C gefördert. Durch Applikation von VEGF-C an Schnittkulturen von Mausembryonen konnte lymphangiogenes Potential in weiten Bereichen der Embryonen nachgewiesen werden.Zur Identifizierung und Charakterisierung von zirkulierenden …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
… that vascular endothelial growth factor (Vegf) C (Vegfc) and Vegfd mRNA levels are significantly increased early during pregnancy and that proteolytically-processed, active VEGF-D is expressed selectively in pregnant, but not virgin mouse mammary glands, corresponding with the stage of …
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THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES
… – Gal-3; Vascular Endothelial Growth Factor C – VEGF-C; Chitinase-3-like Protein 1 – YKL-40; Procollagen Type I N-Terminal Propeptide – PINP) were quantified in plasma of the cohorts using ELISA. THP-1 cells, an immortalized human monocytic cell line, were employed in vitro to assess the …
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
… stabilizes ARE-containing mRNAs, e.g. TNFα, VEGF, c-FOS, favoring specific protein translation. TNFα mRNA is one of the most important target mRNA of HuR since the protein encoded by this gene mediates the inflammatory response and its overexpression is correlated with autoimmune diseases and …
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Examining location-specific invasive patterns: linking interstitial fluid and vasculature in glioblastoma
… interstitial fluid drainage. Over-expression of VEGF-C in the tumor microenvironment neither enhanced drainage nor altered invasion in comparison to our control, indicating other tumor-secreted growth factors, such as VEGF-A, may play a larger role in mediating flow and invasion. Taken together, …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… response to Vascular Endothelial Growth Factor (VEGF) or Vascular Endothelial Growth Factor-C (VEGF-C) stimulation. In vitro assays demonstrated that Notch activation inhibits HDLEC proliferation, migration, and capillary network formation; these effects were coincident with increased levels of …
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Regulation of VEGFR-3 expression and lymphangiogenesis in normal and inflamed tissues
Elevation of VEGFR-3, the primary mediator of lymphangiogenesis (i.e., new lymphatic vessel formation), is frequently associated with inflammation related to chronic disease and cancer. In the latter case, VEGFR-3 dependent lymphangiogenesis induced by inflamed tumors increases the incidence of …
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Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus
… of angiogenic factors Ang- 1, PDGF-B and VEGF-C but, in contrast, showed positive correlation with the angiogenesis cytokine, VEGF-A. Knock-down of NDRG1 expression with siRNA had no effect on anchorage-independent cell proliferation or apoptosis but did inhibit VEGF-A expression. …
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The physiological significance of insemination in programming pregnancy outcome
… and angiogenesis, MMP - 2, MMP - 3 and VEGF - C, were also shown to be increased at the time of implantation after seminal plasma exposure. Additionally the generation of T - regulatory cells in uterine tissues, demonstrated by the up - regulation of the transcription factor FOXp3 was …
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Role of KATP channels in angiogenesis
… to CNP or Vascular Endothelial Growth Factor (VEGF) indeed require KATP activation. We undertook a dual-pronged approach, based on both in vivo and in vitro experimental approaches. In vivo, chick embryo chorioallantoic membrane (CAM) angiogenesis was similarly enhanced by the direct KATP …
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Μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 και συσχέτισή τους με την οδό μεταγωγής σήματος EpoR/ JAK-2/ STAT-5 στους όγκους εγκεφάλου του ανθρώπου
… η Epo διαντιδρά με τον παράγοντα αγγειογένεσης VEGF ενδυναμώνοντας την αγγειοδραστικότητά του και συχνά οι δύο αυτοί αναπτυξιακοί παράγοντες συνεκφράζονται, ε) ερευνητικά δεδομένα υποδεικνύουν ένα δυνητικό ρόλο του άξονα VEGF/JAK-2/ STAT-5 στην αγγειογένεση στον καρκίνο και στ) σε πολλά …