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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 52 for “"VEGF-A"”.

  1. A Kinetic Study of Anti-VEGF-A Polyclonal Antibodies and Anti-VEGF-A ssDNA Aptamers

    Hedeen, Heather A2012

    … aptamers perform similarly to antibodies, anti-VEGF-A polyclonal antibody and anti-VEGF-A ssDNA aptamer were evaluated against vascular endothelial growth factor A (VEGF-A) using Surface Plasmon Resonance (SPR). It was hypothesized that the anti-VEGF-A aptamer had the same, if not better, …

    calpoly Repository record

  2. Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes

    North, Morgan HunterVirginia Tech2020

    … (HIF)-Vascular Endothelial Growth Factor-A (VEGF-A) and HIF-Erythropoietin (EPO) pathways. RNA sequencing (RNA-Seq) data from our previously published experiments revealed a potentially novel VEGF-A splice variant with excision of the VEGF Receptor-1 (VEGFR-1)/Flt-1 binding domain, rendering …

    vt Repository record

  3. Expression of Vascular Endothelial Growth Factor-A and its Receptors in Uteroplacental Tissues of the Normotensive and Hypertensive Pregnant Rat

    He, HuilingVictoria University1999

    … shown that vascular endothelial growth factor A (VEGF-A) is a potent angiogenic factor, that is, it is responsible for the formation of new blood vessels from existing vessels. VEGF-A has been shown to be expressed in uteroplacental tissues, particularly during implantation. Levels of VEGF-A mRNA …

    vu-aus Repository record

  4. Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model

    Belagodu, Amogh P.University of Illinois at Urbana-Champaign2017

    … role of vascular endothelial growth factor A (VEGF-A), a downstream component of mGluR. This dissertation will outline a series of studies where we demonstrate that VEGF-A is elevated in adult FXS mice and that modulation of this elevated VEGF-A can attenuate many FXS abnormalities. In Chapter …

    uiuc Repository record

  5. A novel role for Sprouty2 in co-ordinating airway and vascular growth of the fetal lung.

    Walker, David JohnUniversity of Dundee2013

    … of the Vascular Endothelial Growth Factor (VEGF-A) promoter. Mutation of SPRY2 at tyrosine 55 (Y55) and SH3 motifs induced HIF-1a transcriptional activity while by contrast; cysteine mutation suppressed this activity and abolished SPRY2 interaction with the VEGF-A promoter. Knockdown of …

    dundee Repository record

  6. Discovering angiogenic cell signaling landscapes: Quantitative mapping through experiment and computation

    Mamer, Spencer BruceUniversity of Illinois at Urbana-Champaign2019

    … ligand-receptor interactions—primarily via VEGF-A:VEGFR2 binding. But targeting the VEGF family alone has not achieved the promise of stable vascular control, because angiogenesis involves other signaling axes, such as the PDGFs. In cancer, for example, anti- angiogenic therapeutics …

    uiuc Repository record

  7. Einfluss von Mistelextrakt, Selen, Kavir-Protein und Ascorbinsäure auf die Genexpression angiogener Wachstumsfaktoren und das Sprossverhalten humaner Granulosazellen

    Hovemann, Inken

    … Tie2, den Vascular Endothelian Growth Factor VEGF A sowie dessen Rezeptor KDR exprimieren. Dies eröffnet die Möglichkeit eines autokrinen Loops bei GC. <br>(1) Die Stimulation mit Mistelextrakt führte bei den GC zu einer signifikanten Verminderung der VEGF A-Expression. Trotzdem beeinflusste …

    freiburg-diss Repository record

  8. The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis

    Roybal, Jonathon D2011

    … enhance tumorgrowth and invasion by secreting VEGF-A that binds to VEGFR1, a processrequired for tumor growth and metastasis in mice and correlated with a poorprognosis in lung adenocarcinoma patients. In this study, we discovered thatmiR-200 blocked CAF-induced tumor cell invasion by directly …

    uthsc Repository record

  9. The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer

    Alabi, AndrewUniversity of Hull2013

    … spread and re-growth of colorectal cancer (CRC). VEGF-A is one of the most studied angiogenic agents. A significant degree of the morbidity and mortality associated with colorectal cancer is related to the degree of tumour vascularity. As a consequence, considerable research has been undertaken in …

    hull Repository record

  10. From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies

    Dilwali, SonamMassachusetts Institute of Technology2014

    … between vascular endothelial growth factor (VEGF-A) and hepatocyte growth factor (HGF) was found in Schwann cells, VS cells and in cochlear cells. VEGF-A neutralization in VS secretions could not rescue cochlear degeneration but VEGF-A or HGF receptor knockdown was cytostatic in VS cells. …

    mit Repository record

  11. Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus

    Bracher, Jacqueline ClaireDivision of Medical Biochemistry2009

    … of angiogenic factors Ang- 1, PDGF-B and VEGF-C but, in contrast, showed positive correlation with the angiogenesis cytokine, VEGF-A. Knock-down of NDRG1 expression with siRNA had no effect on anchorage-independent cell proliferation or apoptosis but did inhibit VEGF-A expression. …

    cape-town Repository record

  12. Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.

    Hegde, Veda VUniversity of Essex2020

    … of ZFP36L1 in regulating expression of TNF α and VEGF A as well as of the adhesion receptor CD44 involved in lymphocyte activation, haematopoiesis and tumour metastasis. In this study we also report data on the detection and quantification of ZFP36L1 in several tumour cell lines such as THP1, …

    essex Repository record

  13. Gene switches and their applications in eukaryotic systems

    Liang, JingUniversity of Illinois at Urbana-Champaign2013

    … switch that is able to regulate the endogenous VEGF-A expression in mammalian cell. The gene switch is specifically and reversibly controlled by 4,4’-dyhydroxybenzil, a small molecule, non-steroid synthetic ligand, which acts orthogonally in a mammalian system. After optimization of the gene …

    uiuc Repository record

  14. Transcription Factor Engineering: Tools and Applications

    McLachlan, Michael J.University of Illinois at Urbana-Champaign2011

    … gene vascular endothelial growth factor-A (VEGF-A) was targeted for control by a gene switch. The effect of construct design was evaluated using a VEGF-A promoter controlled luciferase gene and performance was impacted by the choice of DNA binding domain, activation domain, and the order of …

    uiuc Repository record

  15. Effects of ionizing radiation on normal and tumor-associated lymphatic vessels

    Lobo, Jennifer DMassachusetts Institute of Technology2007

    … including vascular endothelial growth factor-A (VEGF-A), VEGF-C and AZD2171, a tyrosine kinase inhibitor of the VEGF receptors, were tested as radiation sensitizers and protectors. Our results indicate that VEGF-A and VEGF-C are radiosensitizers while AZD2171 did not modulate the radioresponse. …

    mit Repository record

  16. Characterization of the expression of angiogenic factors in the feline placenta during development and in feline cutaneous squamous cell carcinoma

    Gudenschwager Basso, Erwin Kristobal FelipeVirginia Tech2018

    … and interaction of different isoforms of the VEGF family. Microscopic analysis of tissue specimens from different stages of pregnancy revealed increased thickness of the LZ, especially during early to mid-gestation, at which time the tissue is composed of abundant materno-fetal …

    vt Repository record

  17. Is melanoma associated leucoderma (MAL) a distinct entity compared to classial vitiligo?

    Elsayed, Marwa A.T.A.University of Bradford2015

    … including p21, p76MDM2, MDM4/MDM4phospho, SPARC, VEGF-A and TGF-β1. In part II, we wanted to characterize MAL and compare this peculiar leucoderma with classical vitiligo using the same protein panel and methodologies. To achieve our goals, we used in vivo FT-Raman spectroscopy, in vitro cell …

    bradford Repository record

  18. Molecular Characterization of Trefoil factor 1 in Gastric Carcinoma

    Muniraj, NethajiResearchSpace@Auckland2012

    … of TFF1 in AGS and MKN45 cells increased VEGF-A expression and promoted tumour angiogenesis in the gastric carcinoma cells through increased VEGF-A expression. Moreover, I demonstrated that the forced expression of TFF1 increased endothelial cell tube formation, proliferation, survival, …

    auckland-ms Repository record

  19. Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1

    Rittler, Matthew RobertVirginia Tech2008

    The vascular endothelial growth factor (VEGF) family is prominently involved in angiogenesis, the formation of new vasculature. Overexpression has been linked to pathological conditions including solid tumor growth. Responses to VEGF are mediated by Flt-1 and KDR, two cell-surface receptors …

    vt Repository record

  20. Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment

    Mandel, Erin R.2016

    … (TIMPs), vascular endothelial growth factor-A (VEGF-A) and thrombospondin-1 (TSP-1). The objective of this dissertation was to examine how alterations to the microenvironment impacted the appropriate microvascular remodeling responses to alterations in flow. The skeletal muscle microenvironment …

    york Repository record

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