Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"VEGF signalling"”.
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The role of AMP-activated protein kinase in endothelial VEGF signalling
… target in the dysfunctional endothelium. VEGF has been established as the prime angiogenic molecule during development, adult physiology and pathology. VEGF stimulates NO production, proposed to be a result of phosphorylation of Ser-1177 on eNOS, a residue also phosphorylated upon AMPK …
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
… of the haematopoietic and vascular systems. VEGF is a mitogen that stimulates cell survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows PRH can control cell survival through the modulation of …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… heart failure, via dysregulated BMP and VEGF signalling pathways. We hypothesised that treatment with recombinant BMP10 protein would restore BMP signalling and rescue disease phenotype. Methods: Human prodomain-bound BMP10 (pBMP10) was generated in-house. The mouse colony was transferred …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… but BMP9 is known to inhibit pro-angiogenic VEGF signalling. A microarray study conducted by the Morrell group in pulmonary artery endothelial cells after treatment with BMP9 revealed Semaphorin 3G (SEMA3G) as a potential BMP9-regulated gene. Class 3 semaphorins have been implicated in …
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Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… the vascular endothelial growth factor (VEGF) has been characterised as a major regulator of both physiological and pathological angiogenesis. Therefore, the characterisation of the molecular mechanisms that regulate VEGF-induced angiogenesis is essential to develop therapeutic strategies …