Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 431 for “"VEGF"”.
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A Kinetic Study of Anti-VEGF-A Polyclonal Antibodies and Anti-VEGF-A ssDNA Aptamers
… aptamers perform similarly to antibodies, anti-VEGF-A polyclonal antibody and anti-VEGF-A ssDNA aptamer were evaluated against vascular endothelial growth factor A (VEGF-A) using Surface Plasmon Resonance (SPR). It was hypothesized that the anti-VEGF-A aptamer had the same, if not better, …
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Examining physiological roles of adipose derived VEGF: Consequences in substrate availability and endurance exercise capacity in adipocyte specific VEGF deficient mice
Reducing vascular endothelial growth factor (VEGF) in adipose tissue alters adipose vascularity and metabolic homeostasis. We hypothesized that this would also affect metabolic responses during exercise-induced stress, and that adipocyte-specific VEGF deficient (adipoVEGF-/-) mice would have …
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Diabetic macular oedema: the role of steroids and VEGF
… Overall our results suggested that steroids and VEGF lead to opposing effects on microvascular endothelial cells. Our randomized controlled trial showed that intravitreal triamcinolone was no more beneficial than laser photocoagulation for persistent diabetic macular oedema. A retrospective …
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Contribution of the Unfolded Protein Response to VEGF Expression
… protects cancer cells, in part, by up-regulating VEGFA, which stimulates blood flow to the tumor in a process known as angiogenesis. The interplay between these two stress pathways in tumor cell survival is relatively unexplored.</p> <p>Microarray analysis of the unfolded protein response in a …
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Renal and kardiovaskulär adverse events after anti-VEGF-treatment
… renaler und kardialer Nebenwirkungen nach anti-VEGF-Behandlung. Case reports von Patienten mit refraktären Schilddrüsenkarzinomen und möglicher Nebenwirkungen nach TKI-Behandlung.
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Tear Film VEGF in Dogs with Vascularizing Corneal Disease
… a novel polyester<br />rod and the comparison of VEGF-A concentrations in tears from dogs with normal and<br />vascularized corneas. The first study used polyester rods for tear collection in dogs. Fluid volume and VEGF recovery characteristics, as well as potential binding of VEGF to the rod, …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… induced by vascular endothelial growth factor-A (VEGF). As a result, anti-VEGF therapy is commonly employed for cancer treatment. However, anti-VEGF therapy generally provides modest efficacy in cancer patients and therapy-induced hypoxia results in a less differentiated mesenchymal-like tumor …
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Role of Macrophages In Adaptive Resistance to Anti-Vegf Therapy
… implementation of therapies targeting the VEGF pathway in cancer has been limited by acquired resistance; yet, the mechanisms by which this occurs is unclear. We investigated the role of macrophages in the development of acquired resistance to anti-VEGF antibody (AVA) therapy.</p> …
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유두상갑상선미세암에서혈관내피성장인자(VEGF),혈관내피성장인자수용체-1(VEGFR-1),저산소증유발인자(HIF-1a)의mRNA발현
… 혈관내피성장인자(vascular endothelial growth factor, VEGF)는 신생혈관생성 (angiogenesis)을 일으키는 중요한 인자로 알려져 있다. 최근 진단기술의 발달로 촉지되지 않는 10mm미만의 유두상 갑상선 미세암(papillary thyroid microcarcinoma, 유두상 미세암)의 진단이 급격히 증가하고 있다. 본 연구는 유두상 미세암 조직에서 VEGF와 VEGF의 수용체인 혈관내피성장인자수용체 (vascular endo-thelial growth factor …
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The role of AMP-activated protein kinase in endothelial VEGF signalling
… target in the dysfunctional endothelium. VEGF has been established as the prime angiogenic molecule during development, adult physiology and pathology. VEGF stimulates NO production, proposed to be a result of phosphorylation of Ser-1177 on eNOS, a residue also phosphorylated upon AMPK …
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Comparing Anti-VEGF Antibodies and Aptamers on Paper Microfluidic-Based Platforms
… and aptamers as capture reagents to detect VEGF, using colloidal gold as a particle to visualize detection. Both monoclonal and polyclonal anti-VEGF antibodies were used and showed no signal. On the other hand, the anti-VEGF aptamer produced a visual signal when conjugated to biotin on its …
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Untersuchung der Expression von Cyclooxygenase-2, VEGF und der Gefäßdichte im Nierenzellkarzinom
… Tumorentstehung ein fundamentaler Prozeß, und VEGF nimmt unter den daran beteiligten angiongenen Wachstumsfaktoren eine zentrale Stellung ein. Ziel der vorliegenden Arbeit war es, die Expression der COX-2 im Nierenzellkarzinom zu untersuchen. Im Speziellen sollte geklärt werden, ob die COX-2 im …
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Normalentwicklung und experimentelle Beeinflussung der Endothelzellproliferation durch VEGF im Chorioallantoismembran-Angiogenese-Assay
… des vaskulären endothelialen Wachstumsfaktor (VEGF) und des Differenzierungsfaktors Retinsäure untersucht. Mittels Immuncytochemie wurde die Endothelzellproliferation in der CAM zwischen 6. und 15. Tag detektiert. Die Häutchenpräparate wurden mit bildanalytischen Methoden ausgewertet. Zur …
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
… of the haematopoietic and vascular systems. VEGF is a mitogen that stimulates cell survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows PRH can control cell survival through the modulation of …
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Prognostische Bedeutung der Vascular Endothelial Cell Growth Factor (VEGF)-Immunreaktivität beim Nierenzell-Carcinom
… wie Staging und Grading eines Nierentumors die VEGF-Immunreaktivität zu untersuchen und auf seine Tauglichkeit als Prognoseparameter zu überprüfen. Hierzu wurden parafin-fixierte Präparate von 200 Patienten, die an der Urologischen Universitätsklinik Würzburg zwischen 1985 und 1994 …
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VEGF and Sympathetic Perivascular Nerves Contribute to Hypoxic Remodeling of Ovine Cranial Arteries
… unclear. Because hypoxia increases production of VEGF, known to modulate smooth muscle (SM) phenotype, this thesis explored the hypothesis that VEGF contributes to hypoxic fetal vascular remodeling through direct effects on SM cells and indirectly through perivascular nerves. Using a chronic …
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