Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"VE-cadherin"”.
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… leakage and serious pathological consequences. VE-cadherin—the primary adhesion molecule at cell-cell junctions in vascular endothelial cells—governs the barrier integrity of the vascular endothelium. Previous studies showed that increased tension on VE-cadherin triggers a mechanotransduction …
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Einfluß der extrazellulären Ca2+-Konzentration und des Aktinfilamentsystems auf die homophile Interaktion von VE-Cadherin
… des Gefäßendothels werden durch Verschluß- und Adhärenskontakte vermittelt. Das Ca2+-abhängige Zelladhäsionsmolekül VE-Cadherin vermittelt in Adhärenskontakten die Adhäsion benachbarter Endothelzellen. Es wurde vermutet, daß die extrazelluläre Ca2+-Konzentration und das …
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Flow-induced mechanotransduction in cell-cell junctions of endothelial cells
… We found a 30±6% increase in the number of VE-cadherin molecules in the junctions. The strength of interactions of endothelial cells with surfaces coated with recombinant VE-cadherin protein also increased after laminar flow. These observations suggest that endothelial cell junction proteins …
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An Optogenetic Toolbox for the Interrogation of Dynamic Events During Angiogenesis
… To address the spatiotemporal requirements for VEGF-induced tip cell development, we designed an optogenetic VEGFR2 utilizing the LightR regulatory system. We demonstrated that LightR regulation of RTKs provides spatiotemporal control over VEGFR2 signaling. Furthermore, we demonstrated that …
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Functional studies on receptor-type protein tyrosine phosphatases of the R3 subgroup
… domain. Although their phosphatase domains have been Fstudied in detail the functional roles of their extracellular regions have not been clearly defined. Potential roles in ligand interaction, dimerisation and cell-cell contacts have been reported. Here I used a bimolecular fluorescence …
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Coordinated regulation of the snail family of transcription factors by the notch and tgf-0 pathways during heart development
The Notch and TGF13 signaling pathways have been shown to play important roles in regulating endothelial-to-mesenchymal transition (EndMT) during cardiac morphogenesis. EndMT is the process by which endocardial cells of the atrioventricular canal and the outflow tract repress endothelial cell …
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Mechanical regulation of cell-cell junctions
Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical forces in the tissue environment play a profound role in the growth, …
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Mechanical Regulation of Angiogenesis in a Biomimetic Model
Collective cell migration is required for numerous developmental and pathological processes including angiogenesis, branching morphogenesis, and cancer progression. Dynamic regulation of cell-cell adhesions, transmission of long-range contractile forces across cells, and remodeling of the …
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
… and maintaining cell-cell adhesion. However, the procedure by which cells establish adherens junctions remains largely unclear. We investigated the dynamics of cell-cell junction formation and the corresponding architecture of the underlying cytoskeleton in cultured human umbilical vein …
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Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
Vascular endothelial cells (VECs) regulate their phenotype in response to the frictional force exerted by the flowing blood, fluid shear stress (FSS). The hemodynamics dictating this force determine, to a large extent, the likelihood that a given region of a blood vessel will develop …
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Role of Sodium Arsenite in Atherogenesis
… studies as well as controlled animal studies have associated exposure to arsenic through drinking water with the development of atherosclerosis. In this study, we have shown for the first time that low and environmentally relevant concentrations of arsenic accelerate atherogenesis. The objective …
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Role of Sodium Arsenite in Atherogenesis
… studies as well as controlled animal studies have associated exposure to arsenic through drinking water with the development of atherosclerosis. In this study, we have shown for the first time that low and environmentally relevant concentrations of arsenic accelerate atherogenesis. The objective …
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Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells
… in the cell therapy capability of ES cells and moved this concept one step closer to reality. Embryonic stem cells with their potential for both self-renewal and directed differentiation have received increasing attention in applications in tissue engineering and repair, cell therapy, and …
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Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis
… the periodontal pocket and the high levels of gingipain activity detected in gingival crevicular fluid could implicate a role for gingipains in the destruction of the highly vascular periodontal tissue. To explore the effects of these proteases on endothelial cells, we exposed bovine …
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Zell- und molekularbiologische Charakterisierung neuartiger Zell-Zell-Verbindungsarten in Glioma-Zellen und mesenchymalen Stammzellen
Zell-Zell-Verbindungen ("Junctions") der Adhaerens-Kategorie sind durch zelltypische Kombinationen von Transmembran-Glykoproteinen der Cadherin-Großfamilie und damit assoziierten cytoplasmatischen Plaque-Proteinen bestimmt, die meist Actin-Mikrofilamente verankern. Sie stellen Hauptstrukturelemente …
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Effects of Diethylstilbestrol on Murine Early Embryonic Stem Cell Differentiation Using an Embryoid Body Culture System
Objectives: The effects of estrogens on immune system formation and function are well documented. Diethylstilbestrol (DES), a synthetic estrogen, has been linked to neoplasia and immune cell dysfunction in humans and animals exposed in-utero. In-vitro effects of DES exposure of murine embryonic …
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Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
… (AJ) and tight junction (TJ) proteins (e.g. VE-Cadherin, occludin, ZO-1, claudin-5) jointly consolidate the apical surface of adjacent brain microvascular endothelial cells (BBMvEC’s) creating the blood-brain barrier (BBB), a critical regulator of CNS homeostasis. Junctional disassembly and …
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The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
… cell-cell border localization of endothelial VE-cadherin, the Tight Junction protein Zonula Occludens 1 (ZO1) , and the Gap Junction Protein (GJ) Connexin43 (Cx43). A ZO1-binding-incompetent variant of αCT1, αCT1-I, indicated that these effects on barrier function and barrier-associated …
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… with the increased incidence of neurodegenerative diseases including stroke, though underlying mechanism is not clearly understood. In vivo studies showed that Cd accumulates out-side of blood brain barrier (BBB) and induces the leakage of BBB, suggesting brain endothelium as a putative target. …
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Beta 3 integrins : negative regulators of angiogenesis
A method was developed to isolate and purify primary murine endothelial cells from lung tissue (MLEC). The cells generated by this method were characterized by immuno-fluorescence detection and FACS analysis and expressed specific antigens including PECAM-1, ICAM-1, ICAM-2, VCAM-1 and VE-cadherin. …
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