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Showing 1 to 20 of 48 for “"VDR"”.

  1. Expression und Funktion des Vitamin-D-Rezeptors in malignen Keimzelltumoren des Hodens

    Bremmer, Felix2012

    … spezifischen intrazellulären Vitamin D Rezeptor (VDR), welcher als Liganden-aktivierter Transkriptionsfaktor fungiert. In den letzten Jahren zeigten zahlreiche Untersuchungen zusätzlich zu den physiologischen Wirkungen des VDR, eine VDR-Expression in verschiedenen Tumoren des Menschen. Des …

    goettingen Repository record

  2. Regulation of Human Osteosarcoma Cell Differentiation by Transforming Growth Factor B1 (TGFB and 1a,25- Dihydroxyvitamin D3 : the Mechanism of TGFB1 Potentiation of 1,25D3-induced Alkaline Phosphatase Activity in Human MG63 Osteosarcoma Cell

    Song, XinDe

    … 1α,25-dihydroxyvitamin D<sub>3</sub> receptors (VDR). We demonstrated that alkaline phosphatase activity was regulated at the transcription level. TGFβ<sub>1</sub> at 1 ng/ml alone had little effect on alkaline phosphatase mRNA induction and 1α,25-dihydroxy vitamin D<sub>3</sub> at …

    loma-linda Repository record

  3. Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function

    Kjalarsdottir, Lilja2012

    … (VitD) is a ligand for the Vitamin D Receptor (VDR, NR1I1), which is a member of the family of Nuclear Hormone Receptors (NHR). Previously, the Repa lab identified VDR as the fourth most abundant NHR in mouse islets based on mRNA levels, also, VDR is clearly present in human islets [1]. In the …

    utswmed Repository record

  4. Yüksek kan kurşun düzeyi olan işçilerde vitamin D reseptör gen polimorfizminin kan ve idrar kurşun düzeylerine etkisi

    Bal, CeylanSağlık Bilimleri Enstitüsü2016

    … yoluyla absorblanır. Vitamin D resptörüne (VDR) bağlanınca intesinal kalsiyum absorbsiyonunda görevli kalsiyum bağlayıcı proteinleri kodlayan genleri aktive eder. Böylece intestinal kalsiyum emilimi artar. VDR gen polimorfizlerinni kalsiyum ve kurşun emiliminde önemli bir göreve sahip olduğu …

    ankara Repository record

  5. 건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계

    김, 수경2011

    … pattern of TLRs, AMPs, and vitamin D receptor (VDR) compared with atopic dermatitis and healthy control and whether an association exists between the serum 25(OH)D concentration and the TLRs, AMPs, and VDR expression of skin sample of psoriasis. Materials and Methods: From January 2008 to June …

    ajou Repository record

  6. The roles of vitamin D in cutaneous wound healing: In vitro and ex vivo studies of the effect of 1,25(OH)2D3 and its precursors on human dermal fibroblasts and epidermal keratinocytes in cutaneous wound healing

    Tay, Jing Q.University of Bradford2019

    … the specific intracellular vitamin D receptor (VDR), a member of the nuclear receptor superfamily. However, epidermal keratinocytes, in addition to being target cells, have enzymes required for autocrine production of 1,25(OH)2D3. They can convert cholecalciferol to 1,25(OH)2D3 via …

    bradford Repository record

  7. Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents

    Lin, Zongtao2018

    … in potent activation of the vitamin D receptor (VDR), we hypothesized that the chain length and composition of these types of analogs also containing a 20-hydroxyl group would affect their biological activities. In this study, we designed and synthesized a series of Gemini 20S(OH)D3 analogs. …

    tenn-hsc Repository record

  8. Nuclear receptor co-repressor actions in bladder cancer

    Abedin, Syed AsadUniversity of Birmingham2010

    … factors. In the current study, expression of VDR and Farnesoid-X-receptor (FXR) protein is demonstrated along with relative mRNA expression of a range NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is over-expressed in RT-112 (1.6 fold) and EJ-28 cells …

    birmingham Repository record

  9. Relationship between diabetes and bone health status in adults with diabetes

    Naseri Kouzehgarani, GhazalUniversity of Illinois at Urbana-Champaign2012

    … bone mass density (BMD) and vitamin D receptor (VDR) gene marker of adult men and women with pre-, type 1 and type 2 diabetes (n=54). Subjects were recruited from faculty, staff and students of the University of Illinois at Urbana-Champaign, as well as participants from the Senior High Rise DM …

    uiuc Repository record

  10. Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease

    Ayouk, Nypiat MartinCreighton University2016

    … decrease mRNA and protein expression of VDR, IκBα, and cyp27B1 in HepG-2. Treatment of HepG-2s with calcitriol significantly decrease mRNA and protein expression of importin-α3 and attenuate the effects of pro-inflammatory cytokines to induce importin-α3 mRNA and protein expression. …

    creighton Repository record

  11. Efectos antineoplásicos de nuevos análogos del 1α,25(OH)_2vitamina D_3

    Salomón, Débora Gisele2013

    … usualmente requieren del receptor de vitamina D (VDR) para ejercer su accion antitumoral. Teniendo en cuenta los resultados obtenidos para el C10 en gliomas y sabiendo que, hasta el momento, no se ha reportado la expresión de VDR en éstos, nos propusimos también estudiar la expresión y el rol de …

    uns-ar Repository record

  12. Efectos antineoplásticos y antiinflalmatorios de agonistas del receptor vitamina D en el sarcoma de Kaposi

    Tapia, Cinthya Mariela2020

    … la expresión de HIF-1α en forma dependiente del VDR, no así de VEGF, que aumentó independientemente de la disminución de HIF-1α y EGR-1, posiblemente por regulación directa del promotor de VEGF por parte del VDR. A su vez, la expresión del mensajero del factor anti-oncogénico JunB aumentó, …

    uns-ar Repository record

  13. Die Expression von Androgen-, Vitamin-D-Rezeptor, FHL-2 sowie des Bone Sialo Proteins in primären Mammakarzinomen

    Herrle, Florian Michael

    … der Androgenrezeptor (AR), Vitamin-D-Rezeptor (VDR) und das Bone Sialo Protein (BSP) als mögliche prädiktive bzw. prognostische Faktoren diskutiert. Der Androgenrezeptor-Koaktivator Four-and-a-half-LIM-domain-protein-2 (FHL-2) wurde erst kürzlich als gewebespezifischer Kofaktor des AR …

    freiburg-diss Repository record

  14. The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma

    Trowbridge, RyanCreighton University2014

    … The effects of 1,25(OH)2D are mediated by VDR. Vitamin D receptor is expressed in normal gastric cardia, Barrett’s esophagus, and esophageal adenocarcinoma, but absent in normal esophageal squamous mucosa. Staining intensity of VDR assessed by immunofluorescence correlates inversely with …

    creighton Repository record

  15. Role of Vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: a randomized double blind placebo controlled trial

    Sai, AdarshCreighton University2011

    … protein and the effect of vitamin D receptor (VDR) and vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) on serum 25OHD levels. | The primary objective of this study was to determine the effect of genotypes based on VDR and DBP SNPs on the dose response to vitamin D in …

    creighton Repository record

  16. Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival

    McCain, StephenQueen's University Belfast2020

    … was a dose-response association between higher VDR expression and improved overall survival. In the highest tertile of VDR expression there was a 51% significantly lower risk of death (HR 0.49 95% CI 0.25-0.96) compared to the lowest tertile of VDR expression. In the cancer specific survival …

    qu-belfast Repository record

  17. Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches

    Battaglia, SebastianoUniversity of Birmingham2010

    … by the knock down and its activation via VDR was modeled with a systems biology approach to identify the mechanistic events behind CDKN1A transcriptional regulation via miRNAs. Differential equation models revealed a time-sensitive activation, VDR-dependent, of the miRNA-miR106b that leads …

    birmingham Repository record

  18. “Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”

    Veronica Alejandra Tovar SepulvedaThe University of Texas Medical Branch2005

    … a negative vitamin D response element (nVDREhPTHrP) within the human PTHrP gene; interaction of the vitamin D receptor (VDR) with this nVDRE is decreased by 1,25(OH)2D3. However, transient transfection of nVDREhPTHrP cloned upstream of the SV40 promoter downregulated promoter activity in …

    utmb Repository record

  19. Estudio de la apoptosis y autofagia como parte del mecanismo antineoplásico de la vitamina D en el sarcoma de Kaposi

    Suares, Alejandra Carolina2018

    … de A20 por un mecanismo dependiente del VDR y un pico de inactivación en la fosforilación de BAD acompañado por la formación de complejos con Bcl-2, alterando posiblemente la integridad de la mitocondria. También, se demostró que el 1α,25(OH)2D3 y TX 527 inducen autofagia a través de la …

    uns-ar Repository record

  20. Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.

    Fischer, Kimberly D.Creighton University2015

    … its actions through the vitamin D receptor (VDR) inducing a number of biological processes. To better understand the mechanisms underlying EMT and the nature of vitamin D modulation in the airway epithelium, human bronchial epithelial cells were stimulated with both calcitriol and …

    creighton Repository record

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