Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"VDJ-seq"”.
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… of an antigen receptor on the cell surface. Subsequent selection stages remove non‑functional and autoreactivity receptors from the final pool of antigen responding B cells that ultimately give rise to antibody secreting plasma cells. Understanding the complexity of the recombination processes …
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Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… (J) genes are differentially rearranged in VDJ recombination. This assembles a complete B cell receptor (BCR) and is the primary step in producing a diverse BCR repertoire; an essential requirement for a robust adaptive immune response. The roles of interleukin-7 receptor, pre-BCR and …