Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"VCP"”.
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Biochemical and Structural Insights into VCP Unfoldase and WRN Helicase Complexes
<p>Valosin-containing protein (VCP or p97 in mammals, Cdc48 in yeast) is an essential member of the AAA (ATPases associated with diverse cellular activities) protein superfamily. As its family name suggests, VCP function is implicated in a broad range of biological pathways including protein …
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The Vaccinia Virus A56/Vcp Complex: Mechanism of Formation and Implications for Virulence
… are the vaccinia complement control protein (VCP) and A56, the vaccinia hemagglutinin. VCP had been previously described as a virulence factor that was secreted from infected cells and blocked the activation of the complement cascade; A56 was known to bind another viral protein, K2. We have …
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Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation.
Valosin containing protein (VCP)/p97 is a hexameric ATPase of the AAA family, which regulates a wide array of essential cellular processes. Dominant mutations in the N-domain of the VCP give rise to the complex disease syndrome known as Inclusion body myopathy with Paget disease of the bone and …
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Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia
… The vaccinia virus complement control protein (VCP) has the ability to simultaneously inhibit the classical and the alternative complement pathways by binding to the early components C3b and C4b. The complement component C3 is known to be the central route to all of the known complement …
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Virtual child pornography – policing fantasy? A critical evaluation of the justifications for the criminalisation of virtual child pornography (VCP)
… (hereafter known as virtual child pornography or VCP) were not illegal to possess. However, after a period of consultation in which the government acknowledged there was no research to suggest actual harm caused as a result of such images, only potential harm, these fantasy images became subject …
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
… their degradation, it has been established that VCP, an unfoldase, is recruited. VCP provides the capability to degrade these large viruses. I sought to understand how VCP is recruited to the ADIN pathway. I performed an siRNA screen targeting known VCP adaptors using a TRIM21- dependent …
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A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
… vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, thereby preventing …
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Sequential Actions of VCP/p97 and the Proteasome 19S Regulatory Particle in Sterol-Accelerated, ER-Associated Degradation of HMG CoA Reductase
… defined reactions mediated by the AAA-ATPase VCP/p97 and augmented by the nonsterol isoprenoid geranylgeraniol. Here, we report that the oxysterol 25-hydroxycholesterol and geranylgeraniol combine to trigger extraction of reductase across ER membranes prior to its cytosolic release. This …
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Delivery of Vaccinia Virus Complement Control Protein (VCP) and Curcumin to the rodents' brain : implications in Alzheimer's disease and HIV dementia
Includes abstract. Includes bibliographical references (p. 245-262).
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
… activators in valosin-containing protein (VCP)/p97, a AAA unfoldase whose loss of function has been linked to protein aggregation-based disorders. For the chemical genetics approach, we designed ASPIRe-1 (Allele-Specific, Proximity-Induced Reactivity-based inhibitor-1), a cell-permeable …
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Ventilación controlada por volumen vs. ventilación controlada por presión en pacientes sometidos a ventilación de un solo pulmón
… escogido. La ventilación controlada por presión (VCP) es un modo alternativo ampliamente usado en pacientes con falla respiratoria por sus características de aporte de flujo y presión. En este estudio la VCP fue usada en los pacientes que requerían OLV y sus efectos sobre las presiones en la vía …
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An Interpretative Phenomenological Analysis of Clients’ Experiences of Videoconferencing Psychological Therapy in the Context of the COVID-19 Pandemic
… of videoconferencing psychological therapy (VCP), as it became challenging for clinicians to offer in-person sessions. While this delivery format has become more widespread, qualitative research is lacking in exploring the clients’ experiences of VCP in depth.<br/><br/><b>Objective: </b>This …
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Biomechanical and physiological investigations in the IBMPFD animal model
… by mutations in the valosin-containing protein (VCP) gene. Knock-in mice expressing the common human p.R155H VCP mutation develop a progressive myopathy with ubiquitin-positive inclusion bodies, accumulation of abnormally shaped mitochondria in skeletal muscle and focal bone degradation …
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Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
… MQC requires valosin-containing protein (VCP)-dependent Mitofusin/Marf proteasomal degradation to prevent damaged mitochondria from fusing with healthy ones, facilitating their clearance by autophagy (mitophagy). clu was found to genetically interact with PINK1 and parkin to regulate …
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Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
… domain containing autophagy adaptors (SQSTM1, VCP, OPTN) and prion-like domain containing stress granule proteins (HNRNPA2B1, HNRNPA1, MATR3, TIA1). Previous studies identified that a non-pathogenic variant of the non-classical MSP protein, TIA1 N357S , can act as a phenotype modifier with …
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Impact of Indoor Sources of Emission on Ambient Air Quality
… evaporation of volatile chemical products (VCPs), a broad class of sources emerging as a significant contributor to urban air pollution as emissions from classic sources like traffic has decreased over the last decades. Studying the effect of indoor physicochemical phenomena on emissions is …
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Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
… alphaviruses. Valosin containing protein (VCP) was also shown to interact with the E1 glycoprotein. Exploration of VCP's interaction with alphavirus E1 has never been explored, yet it was previously shown to be involved in alphavirus replication. Co-localization and co-immunoprecipitation …
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Investigating volatile organic compound composition in Houston, Texas amidst an atmospheric regime shift.
… sources, known as volatile chemical products (VCPs), include organic solvent-based personal care products, cleaning agents, and industrial inks and adhesives. These changes in emission inventories highlight a substantial shift from historical VOC source profiles and represents a new challenge …
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Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… of the ERAD ATPase, valosin-containing protein (VCP/p97), where it becomes concentrated in the ER, co-localizing with both DGAT2 and MGAT2. Interaction of DGAT2 and MGAT2 with VCP/p97 was also demonstrated in situ. We took a non-targeted mass spectrometry approach to identify proteins interacting …
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Investigating volatile organic compound composition in Houston, Texas amidst an atmospheric regime shift.
… sources, known as volatile chemical products (VCPs), include organic solvent-based personal care products, cleaning agents, and industrial inks and adhesives. These changes in emission inventories highlight a substantial shift from historical VOC source profiles and represents a new challenge …
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