Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"VCAM"”.
-
Effects of Cadmium on VCAM-1 Expression
… 카드뮴을 처리한 후 Vascular cell adhesion molecule-1 (VCAM-1)의 변화와 Mitogen Activated Protein Kinase (MAPK) 저해제들이 VCAM-1의 변화에 미치는 효과를 관찰하였다. 그 결과, 카드뮴 처리 2시간째 VCAM-1 mRNA의 발현이 증가하였고 카드뮴 처리 4시간째에 VCAM-1 단백질 발현이 증가하였다. 그리고 이러한 부착분자의 발현변화가 어떤 세포신호체계를 경유하는지를 알아보기 위해 신호전달물질인 MAPK의 억제제를 사용한 결과, p38 MAPK 억제제 …
-
Perfil plasmático da ICAM-1 e da VCAM-1 no pós-operatório cardíaco de lactentes submetidos à circulação extracorpórea
… e a molécula de adesão celular-vascular-1 (VCAM-1). Formas solúveis destas moléculas apresentam variações de seus níveis durante cirurgias cardíacas com uso de CEC. Há poucos dados na literatura relacionados ao comportamento destas moléculas após cirurgia cardíaca com uso de CEC em …
-
Interaktion von Leukozyten mit endothelialen Adhäsionsmolekülen und ihre Inhibition durch Expression von konkurrierenden Fusionsproteinen
… übernimmt das vaskuläre Zelladhäsionsmolekül-1 (VCAM-1; CD106) eine besondere Rolle, da es sowohl an der Adhäsion als auch an der Transmigration von Monozyten beteiligt ist. Von besonderem Interesse ist seine Funktion bei dem chronisch entzündlichen Phänomen der Atherosklerose, weshalb die …
-
Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… expression of vascular cell adhesion molecule 1 (VCAM-1) was compared in DKO and Apoe-/- brachiocephalic arteries. VCAM-1 immunostaining was significantly greater on the endothelial cells of DKO arteries at 3 months compared to age-matched Apoe-/- mice. At 6 months, DKO and Apoe-/- mice had …
-
Heterogeneity of injury in vasculitis: influence of anti neutrophil cytoplasm antibody IgG subclass and endothelial susceptibility.
… human umbilical vein endothelial cells. Surface VCAM-1 was reduced on GEC and GEC demonstrated reduced leukocyte capture. RNA array analysis demonstrated a reduction in the GEC gene responsible for post translational modification of VCAM-1 to a sialoglycoprotein. VCAM-1 expression by GEC may be a …
-
Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… ligands vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN), while inhibition of MEK/ERK by U0126 had no effect. Microscopy showed that RAF inhibition leads to significant inhibition of T cell spreading on VCAM-1. The association of α4β1 integrin with the actin cytoskeleton was …
-
Placental angiogenesis and immune-privilege in normal and pathological pregnancies
… in PE and IUGR. On the other hand, levels of VCAM-1 and its mRNA were decreased in a gestation dependent manner, but these levels were further decreased in IUGR placentae, suggesting that diminished levels were associated with placental insufficiency. Moreover, experiments using hypoxia …
-
Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis
… (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) increased in both WT and IFN-g-/- mice following infection, there were more VCAM-1+ vessels in brains of infected WT than infected IFN-g-/- mice; in contrast, numbers of ICAM-1+ vessels did not differ between strains. We did not detect …
-
Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier
… TNF-α. This, in turn, is expected to decrease VCAM-1 expression and mitigate BBB dysfunction. This hypothesis has been verified by treating BBB endothelial cells with inflammatory cytokines like TNF-α, which inhibited insulin signaling and increase the expression of vascular cell adhesion …
-
Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
… could be reduced by blocking CD49d on HSCs or VCAM-1 in vivo. Blockade of HSC CD18, CD31 or CD44 did not alter adhesion. HSC adhesion in sham treated CD31-/- animals was raised compared to wild-type animals and IR injury did not further raise this adhesion. Studies in vitro demonstrated that …
-
Peptide targeted imaging of neutrophil invasion in cardiac tissue
… the tissue damage mediated by ICAM-1 and VCAM-1 endothelial cell membrane proteins can be minimized. In this project, we paired ICAM-1 and VCAM-1 blocking peptides with fluorophores to allow for physical and quantitative analysis of peptide binding. To test the specific efficacy of the …
-
CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… cell activation and dysfunction (ICAM-1, VCAM-1 expression), and c) intracellular redox signaling endosomes to regulate adhesion molecule expression. Objectives: The aim of the study was to investigate whether, a) caveolae compartmentalize ROS, regulate localized tyrosine nitration of …
-
The vascular and anti-inflammatory activity of Cyanidin-3-Glucoside and its metabolites in human vascular endothelial cells
… expression of vascular cell adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in endothelial cells. Here, significant bioactivity of C3G metabolites was observed, as 7 out of 12 of the tested treatments reduced CD40L-induced VCAM-1 expression up to 65% (relative to control, p<0.05), eight …
-
Identification of biological markers for neuropsychiatric disorders
… cholesterol, triglycerides, HDLCholesterol, VCAM-1, JCAM-1, glucose and CRP. The results were tested at Pc 0.05 level of statistical significance. ilomocysteine, VCAM-1 and ICAJvI-1 levels were significantly higher in the dementia and depression group, whereas folate, vitamin B12, cholesterol …
-
Fatty acid regulation of adhesion molecule expression in human vascular cells.
… (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin are expressed on endothelial cells and lymphocyte function-associated antigen-1 (LFA-1), very late antigen-4 (VLA-4), are expressed on the leukocytes. The consumption of n-3 polyunsaturated fatty acids (PUFA) from fish and …
-
EVALUATION OF YAK-KONG SOYBEAN (GLYCINE MAX) FOR ITS PHENOLICS AND METABOLITES WITH A FOCUS ON ATHEROSCLEROSIS PREVENTION
… of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-κB (NF-κB), which all are associated with atherosclerosis. Additionally, several hydroxylated metabolites of isoflavones in addition to their precursors were …
-
Implicaciones de las trampas extracelulares de neutrófilos (nets) en la gravedad y complicaciones de la covid-19 (micro-net-covid-19)
… E, molécula de adhesión de células vasculares 1 -VCAM1-, factor de crecimiento endotelial vascular, P-selectina, factor plaquetario 4 y las concentraciones plasmáticas de fibrinógeno y dímero D al ingreso hospitalario, al alta y 14 días después del alta. El ingreso a la unidad de cuidados …
-
The effect of freeze dried whole watermelon powder on endothelial function and vascular health in older adults
… lipoprotein, high-density lipoprotein, ICAM-1, VCAM-1, and P-selectin from baseline to final visits. These findings suggest that consumption of watermelon may reduce the risk or progression of cardiovascular disease from improved lipid and vascular biomarkers.
-
THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… Also, Vascular Cell Adhesion Molecule (VCAM) was upregulated in the endothelium. However, macrophage infiltration and MMP-2 activation was not observed in early AAA development. In order to elucidate the role of endothelial caveolae in the formation of AAA, we induced AAA, as previously …
Page 1 of 4