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Showing 1 to 20 of 34 for “"V-ATPase"”.
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… I have explored the role of the vacuolar H+-ATPase (V-ATPase), the major proton pump for acidifying intracellular vesicles and facilitating lysosomal degradation, in regulating HIF-$\alpha$ turnover. Unbiased forward genetic screens in near-haploid human cells identified that disruption of …
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Organelle remodeling and V-ATPase dynamics in the lysosome regeneration cycle
… assembly/disassembly of the proton pumping V-ATPase and that the enzyme lysosomal phospholipase A2 (LPLA2/PLA2G15), a previously proposed target of cationic amphiphilic drugs (CADs), plays a role in bis(monoacylglycerol) phosphate (BMP) synthesis. Chapter 1 of this thesis provides an …
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The Role of a Neuron-Specific V-ATPase in Synapse Specification, Function, and Maintenance
The Vacuolar-type (V-) adenosine triphosphatase (ATPase) is a proton-pumping nanomachine consisting of two multi-subunit, reversibly associating protein sectors, the cytosolic V1 sector and the membrane-bound Vo sector. The V1/Vo holoenzyme hydrolyses ATP to translocate protons across biological …
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XvVHA-c``1- a novel stress responsive V-ATPase subunit c`` homologue isolated from the resurrection plant Xerophyta viscosa Baker
Includes bibliographical references.
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Regulation der vakuolären H(+)-ATPase durch reversible Proteinphosphorylierung
Die vakuoläre Protonen-ATPase, kurz V-ATPase, ist ein multimerer Enzymkomplex, der in fast jeder eukaryotischen Zelle zu finden ist und den aktiven elektrogenen Transport von Protonen über Membranen katalysiert. Die Aktivität der V-ATPase ist essentiell für eine Vielzahl physiologischer Prozesse. …
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MODULATING TFEB ACTIVITY IN THE BIRT-HOGG-DUBE' SYNDROME BY TARGETING THE VACUOLAR ATPASE
… were genes encoding subunits of the vacuolar ATPase (V-ATPase). The V-ATPase is a proton-pump protein complex responsible for maintaining the low pH of lysosomes, and it has been described as a positive regulator of mTORC1 signaling, although the exact contribute of the V-ATPase to the amino …
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Structural characterisation of V-ATPases by electron microscopy
Vacuolar H+-translocating ATPases (V-ATPases) are fundamentally important proteins. They pump protons into the interior of most cellular endomembrane compartments at the expense of ATP. V-ATPases are comprised of a membrane-integrated proton-translocating part (V0) and a soluble catalytic part …
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pH Regulatory Molecules In The Tumour Microenvironment: Modulators Of Aggressiveness And Immune Profile Of Human Hepatocellular Carcinoma
… such as carbonic anhydrase (CA) IX, XII and V-ATPase complex, but the relevance of these molecules in HCC is poorly defined. <br></br><br></br> <b>Aim:</b> The aim of this study was to dissect the relationships between pH regulatory molecules and the aggressive behaviour of malignant …
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Räumliche und zeitliche Aspekte der intrazellulären pH-Regulation in Epithelien
… wird durch eine apikal lokalisierte vakuoläre H+-ATPase (V-ATPase) energetisiert. Stimulierung der Speicheldrüsen mit 5-HT aktiviert die apikale V-ATPase, die Protonen aus der Zelle in das Drüsenlumen transportiert. Trotz des auswärts gerichteten Protonentransportes führt die 5-HT-Stimulierung …
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Study of the Yeast Vacuolar-type ATPase by Electron Cryomicroscopy
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that use energy from hydrolysis of adenosine triphosphate (ATP) to pump protons across membranes and control the pH of many intracellular compartments. ATP hydrolysis in the soluble catalytic region of the enzyme is coupled to proton …
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Investigating the invasive and cytoprotective properties of the heme binding protein HRG-1 in cancer cells
… pathways in cancer cells through its effects on VATPase activity and heme transport. Plasma membrane-localised V-ATPase activity correlates with enhanced metastatic potential in cancer cells, which is attributed to extrusion of protons into the extracellular space and activation of pH-sensitive, …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
… perturbs vacuolar structure, decreases vacuolar ATPase (V-ATPase) proton pumping, and causes partial un-coupling of the V-ATPase. These perturbations were rescued by inositol supplementation. Furthermore, VPA compromised the synthesis of PI3,5P2, which is necessary for stabilization of the …
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Physiological and molecular mechanisms of salt tolerance in barley (Hordeum vulgare L.)
… cytochrome B6, chloroplast ATP synthase and V-ATPase B subunit. The V-ATPase B subunit was up-regulated in Golden Promise and down-regulated in Maythorpe under both short-term and long-term salt stress, which indicates the greater potential of Golden Promise in excluding excess Na+ from the …
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Structural Characterization of F-type and V-type Rotary ATPases by Single Particle Electron Cryomicroscpy
… and some bacteria, ATP is synthesized by V-ATPase that is related to ATP synthase both in structure and function. Both of these enzymes are reversible rotary motors capable of catalyzing ATP synthesis or hydrolysis. The rotation of the central rotor, which is powered by the flow of proton …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
… autophagy requires the interaction between V-ATPase and the ATG16L1-WD40 domain on Rab7-coated endolysosomal compartments. Additionally, we unveiled that STING-induced noncanonical autophagy leads to the activation of MiT/TFE transcription factors (TFEB, TFE3, and MITF), promoting …
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Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
… proteolipid subunits of vacuolar H<sup>+</sup>-ATPase (V-ATPase) at a putative binding site that is distinct from the previously described V-ATPase inhibitors. Together, we demonstrate the utility of this pipeline in the isolation, characterization, and development of novel natural products from …
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Nematicidal, antimicrobial and acaricidal activity of plant secondary metabolites
… of aromatic aldehydes by the inhibition of V-ATPase of the nematode. Second, we demostrate the antimicrobial activity of carob (Ceratonia siliqua) against Listeria monocytogenes. Leaves of the carob tree contain high levels of polyphenolic compounds with antilisterial activity that may act by …
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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis
… assimilation whereas lysosomes, with their v-ATPase-generated acidic lumens, are responsible for iron uptake and rely. In the first part of this work, I focused on lysosomes. Unbiased genetic screens performed on cells grown at sub-lethal levels of lysosomal pH inhibition identified several …
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The development of preclinical strategies for facilitation of lead candidate selection
… vivo</em> testing of a potent V-ATPase inhibitor known as Saliphenylhalamide. The V-ATPase is an endogenous protein that is responsible for acidifying intercellular compartments and has been targeted in the past with <em>in vitro</em> success for treatment of cancer and …
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Zur Bedeutung der polyTC-Motive in den Promotoren und 5‘-UTR-Bereichen konstitutiv exprimierter Pflanzengene
Das Gen der V-ATPase UE c1 aus der Zuckerrübe (Beta vulgaris) besitzt im Promotor und der 5’UTR je eine Polypyrimidinbox. Solche Motive aus sich häufenden TC-Alternierungen sind in pflanzlichen Promotoren und 5’UTRs ein häufig auftretendes Motiv mit bislang weitgehend ungeklärter Funktion. Am …
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