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Showing 1 to 6 of 6 for “"Uterine Leiomyoma"”.
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL …
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Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone
Uterine leiomyomas are known as the most commonly occurring neoplasms in women during their reproductive years. The overall incidence of these benign tumors can be as high as 70-80%, which represents a significant health problem to women. Patients suffer from abnormal uterine bleeding, pelvic pain, …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
<p>It is thought that the growth of uterine leiomyomas may be mediated by the interaction of estrogen receptor alpha (ERα) and growth factor pathways and that phosphorylation of ERα at serine 118 (ERα-phospho-Ser118) is important in this interaction. In tissue, immunoblotting and …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… Eker rats giving rise to complete penetrance of uterine leiomyoma. Based on this, we hypothesized that xenoestrogens, including genistein (GEN) and bisphenol A (BPA), reprogram estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the …
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Gimdos miomos. Klinikinio atvejo pristatymas ir literatūros apžvalga /
… of the literature to understand the mechanism of uterine fibroids, the clinical features of the disease, the main methods of treatment and diagnosis, and to describe a clinical case. Methods: The literature search was performed in the PubMed database. The selection criteria were: english language …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… each playing an important role in supporting uterine functions through intricate interactions. The innermost layer of the uterus, the endometrium, is critical for successful implantation and pregnancy. The smooth muscle cells of the myometrial layer are organized into several sub-layers with …